GBG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBG5_HUMAN
• UniProt AC: P63218
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
• Gene Name: GNG5
• Organism: Homo sapiens (Human).
• Sequence Length: 68
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGSSSVAA ------CCCHHHHHH	47.59	29255136
2	Acetylation	------MSGSSSVAA ------CCCHHHHHH	47.59	20068231
4	Phosphorylation	----MSGSSSVAAMK ----CCCHHHHHHHH	16.48	29255136
5	Phosphorylation	---MSGSSSVAAMKK ---CCCHHHHHHHHH	32.15	29255136
6	Phosphorylation	--MSGSSSVAAMKKV --CCCHHHHHHHHHH	19.92	23401153
11	Acetylation	SSSVAAMKKVVQQLR HHHHHHHHHHHHHHH	37.38	25953088
11	Ubiquitination	SSSVAAMKKVVQQLR HHHHHHHHHHHHHHH	37.38	33845483
12	Ubiquitination	SSVAAMKKVVQQLRL HHHHHHHHHHHHHHH	34.26	24816145
18	Methylation	KKVVQQLRLEAGLNR HHHHHHHHHHHCCCC	26.58	-
27	Ubiquitination	EAGLNRVKVSQAAAD HHCCCCHHHHHHHHH	32.69	21906983
36	Ubiquitination	SQAAADLKQFCLQNA HHHHHHHHHHHHHHC	41.71	23000965
53	Phosphorylation	DPLLTGVSSSTNPFR CCCCCCCCCCCCCCC	21.66	28348404
54	Phosphorylation	PLLTGVSSSTNPFRP CCCCCCCCCCCCCCC	38.48	26657352
55	Phosphorylation	LLTGVSSSTNPFRPQ CCCCCCCCCCCCCCH	25.38	28348404
56	Phosphorylation	LTGVSSSTNPFRPQK CCCCCCCCCCCCCHH	49.19	26657352
65	Methylation	PFRPQKVCSFL---- CCCCHHHHHCC----	2.83	-
65	Geranylgeranylation	PFRPQKVCSFL---- CCCCHHHHHCC----	2.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNB5_HUMAN	GNB5	physical	8636150
GBB1_HUMAN	GNB1	physical	8636150
GBB2_HUMAN	GNB2	physical	8636150
GBB3_HUMAN	GNB3	physical	8636150
GBB4_HUMAN	GNB4	physical	8636150
GBB1_HUMAN	GNB1	physical	19168127
GBB2_HUMAN	GNB2	physical	19168127
GBB3_HUMAN	GNB3	physical	19168127
GBB3_HUMAN	GNB3	physical	22940628
GOGA2_HUMAN	GOLGA2	physical	25416956
K1H1_HUMAN	KRT31	physical	25416956
MDFI_HUMAN	MDFI	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
EP15R_HUMAN	EPS15L1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 2-18, AND ACETYLATION AT SER-2.
PubMed: 12665801