UniProt ID | GBB2_HUMAN | |
---|---|---|
UniProt AC | P62879 | |
Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | |
Gene Name | GNB2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 340 | |
Subcellular Localization | Cytoplasm, perinuclear region . | |
Protein Description | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.. | |
Protein Sequence | MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MSELEQLRQ ------CHHHHHHHH | 51.38 | 25159151 | |
2 | Acetylation | ------MSELEQLRQ ------CHHHHHHHH | 51.38 | 19413330 | |
15 | Methylation | RQEAEQLRNQIRDAR HHHHHHHHHHHHHHH | 32.47 | - | |
23 | Ubiquitination | NQIRDARKACGDSTL HHHHHHHHHHCCCHH | 50.15 | 21906983 | |
25 | S-nitrosylation | IRDARKACGDSTLTQ HHHHHHHHCCCHHHH | 7.54 | 21278135 | |
25 | S-nitrosocysteine | IRDARKACGDSTLTQ HHHHHHHHCCCHHHH | 7.54 | - | |
28 | Phosphorylation | ARKACGDSTLTQITA HHHHHCCCHHHHHHC | 15.59 | 29255136 | |
29 | Phosphorylation | RKACGDSTLTQITAG HHHHCCCHHHHHHCC | 38.27 | 29255136 | |
31 | Phosphorylation | ACGDSTLTQITAGLD HHCCCHHHHHHCCCC | 20.29 | 29255136 | |
34 | Phosphorylation | DSTLTQITAGLDPVG CCHHHHHHCCCCCCC | 12.59 | 25850435 | |
50 | Phosphorylation | IQMRTRRTLRGHLAK CHHHCHHHHHHHHHH | 19.95 | 24719451 | |
57 | Acetylation | TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC | 42.48 | - | |
57 | Ubiquitination | TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC | 42.48 | 21890473 | |
59 | Phosphorylation | RGHLAKIYAMHWGTD HHHHHHHHHHHCCCC | 9.36 | 29496907 | |
67 | Phosphorylation | AMHWGTDSRLLVSAS HHHCCCCCEEEEEEC | 25.35 | 24719451 | |
72 | Phosphorylation | TDSRLLVSASQDGKL CCCEEEEEECCCCCE | 23.36 | - | |
74 | Phosphorylation | SRLLVSASQDGKLII CEEEEEECCCCCEEE | 22.69 | 21712546 | |
78 | Acetylation | VSASQDGKLIIWDSY EEECCCCCEEEEECC | 44.81 | 30588969 | |
84 | Phosphorylation | GKLIIWDSYTTNKVH CCEEEEECCCCCEEE | 14.91 | 28152594 | |
85 | Phosphorylation | KLIIWDSYTTNKVHA CEEEEECCCCCEEEE | 18.34 | 28152594 | |
86 | Phosphorylation | LIIWDSYTTNKVHAI EEEEECCCCCEEEEE | 28.04 | 28152594 | |
87 | Phosphorylation | IIWDSYTTNKVHAIP EEEECCCCCEEEEEE | 25.47 | 28152594 | |
89 | Ubiquitination | WDSYTTNKVHAIPLR EECCCCCEEEEEECC | 33.05 | 21890473 | |
109 | Ubiquitination | TCAYAPSGNFVACGG EEEECCCCCEEEECC | 30.45 | - | |
125 | Phosphorylation | DNICSIYSLKTREGN HHCCEEEEEECCCCC | 23.01 | 24719451 | |
136 | Phosphorylation | REGNVRVSRELPGHT CCCCEEEEEECCCCC | 14.96 | 27794612 | |
145 | Phosphorylation | ELPGHTGYLSCCRFL ECCCCCCEEEEEEEE | 9.15 | 29496907 | |
201 | Ubiquitination | PDGRTFVSGACDASI CCCCCCCCCCCCCEE | 19.24 | - | |
204 | S-nitrosylation | RTFVSGACDASIKLW CCCCCCCCCCEEEEH | 5.25 | 21278135 | |
204 | S-nitrosocysteine | RTFVSGACDASIKLW CCCCCCCCCCEEEEH | 5.25 | - | |
207 | Phosphorylation | VSGACDASIKLWDVR CCCCCCCEEEEHHHC | 13.65 | 28857561 | |
209 | Acetylation | GACDASIKLWDVRDS CCCCCEEEEHHHCHH | 40.82 | 26051181 | |
209 | Ubiquitination | GACDASIKLWDVRDS CCCCCEEEEHHHCHH | 40.82 | 21906983 | |
216 | Phosphorylation | KLWDVRDSMCRQTFI EEHHHCHHHHCCCCC | 14.82 | 24719451 | |
239 | Phosphorylation | VAFFPNGYAFTTGSD EEECCCCEEEECCCC | 12.75 | - | |
301 | Acetylation | CNIWDAMKGDRAGVL CCHHHHCCCCCCEEE | 60.42 | 26051181 | |
301 | Ubiquitination | CNIWDAMKGDRAGVL CCHHHHCCCCCCEEE | 60.42 | 2190698 | |
317 | S-nitrosylation | GHDNRVSCLGVTDDG CCCCCEEEEEECCCC | 3.33 | 21278135 | |
317 | S-nitrosocysteine | GHDNRVSCLGVTDDG CCCCCEEEEEECCCC | 3.33 | - | |
329 | Phosphorylation | DDGMAVATGSWDSFL CCCEEEEECCHHHHH | 25.75 | 28348404 | |
331 | Phosphorylation | GMAVATGSWDSFLKI CEEEEECCHHHHHHH | 24.29 | 24719451 | |
334 | Phosphorylation | VATGSWDSFLKIWN- EEECCHHHHHHHCC- | 26.64 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBB2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBB2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBB2_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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