ID3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ID3_HUMAN
• UniProt AC: Q02535
• Protein Name: DNA-binding protein inhibitor ID-3
• Gene Name: ID3
• Organism: Homo sapiens (Human).
• Sequence Length: 119
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer..
• Protein Sequence: MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISNDKRSFCH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKALSPVRG ------CCCCCCCCC	59.02	18585167
2	Ubiquitination	------MKALSPVRG ------CCCCCCCCC	59.02	33845483
5	Phosphorylation	---MKALSPVRGCYE ---CCCCCCCCCHHH	26.64	23927012
11	Phosphorylation	LSPVRGCYEAVCCLS CCCCCCHHHHHHHHC	15.11	28796482
18	Phosphorylation	YEAVCCLSERSLAIA HHHHHHHCCCCHHHH	19.63	25159151
21	Phosphorylation	VCCLSERSLAIARGR HHHHCCCCHHHHCCC	20.35	-
30	Ubiquitination	AIARGRGKGPAAEEP HHHCCCCCCCCCCCC	61.43	21963094
30	Acetylation	AIARGRGKGPAAEEP HHHCCCCCCCCCCCC	61.43	26051181
48	Phosphorylation	LDDMNHCYSRLRELV HHHHHHHHHHHHHHC	6.83	-
65	Phosphorylation	VPRGTQLSQVEILQR CCCCCCHHHHHHHHH	23.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	CDK2	P24941	PSP
5	S	Phosphorylation	Kinase	PYK2	Q14289	PSP
11	Y	Phosphorylation	Kinase	PYK2	Q14289	PSP
18	S	Phosphorylation	Kinase	PYK2	Q14289	PSP
48	Y	Phosphorylation	Kinase	PYK2	Q14289	PSP
65	S	Phosphorylation	Kinase	ATM	Q13315	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF2	Q9HAU4	PMID:21933340

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ID3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ID3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITF2_HUMAN	TCF4	physical	8999959
TFE2_HUMAN	TCF3	physical	9525934
ITF2_HUMAN	TCF4	physical	9242638
HTF4_HUMAN	TCF12	physical	9242638
TFE2_HUMAN	TCF3	physical	9242638
PAX5_HUMAN	PAX5	physical	12054881
GATA4_HUMAN	GATA4	physical	16556596
NKX25_HUMAN	NKX2-5	physical	16556596
NEMO_HUMAN	IKBKG	physical	20211142
SAP30_HUMAN	SAP30	physical	20211142
MTG8R_HUMAN	CBFA2T2	physical	20211142
PRD14_HUMAN	PRDM14	physical	20211142
ID3_HUMAN	ID3	physical	18255255
ITF2_HUMAN	TCF4	physical	25416956
TFE2_HUMAN	TCF3	physical	25416956
HTF4_HUMAN	TCF12	physical	25416956
ELOC_HUMAN	TCEB1	physical	26735018
VHL_HUMAN	VHL	physical	26735018

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.