| UniProt ID | NKX25_HUMAN | |
|---|---|---|
| UniProt AC | P52952 | |
| Protein Name | Homeobox protein Nkx-2.5 | |
| Gene Name | NKX2-5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 324 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. [PubMed: 22849347] | |
| Protein Sequence | MFPSPALTPTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPEAAAPGLPELRAELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPAYGVGLNPYGYNAYPAYPGYGGAACSPGYSCTAAYPAGPSPAQPATAAANNNFVNFGVGDLNAVQSPGIPQSNSGVSTLHGIRAW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 78 | Phosphorylation | AELGRAPSPAKCASA HHHCCCCCHHHHHHC | 36.18 | 21949786 | |
| 98 | Phosphorylation | AFYPRAYSDPDPAKD CCCCCCCCCCCCCCC | 41.50 | 23684312 | |
| 139 | Phosphorylation | RPRARRRRKPRVLFS CHHHHHHCCCCCHHC | 52.06 | - | |
| 139 (in isoform 2) | Phosphorylation | - | 52.06 | - | |
| 141 | Phosphorylation | RARRRRKPRVLFSQA HHHHHCCCCCHHCHH | 29.78 | - | |
| 141 (in isoform 2) | Phosphorylation | - | 29.78 | - | |
| 151 | Phosphorylation | LFSQAQVYELERRFK HHCHHHHHHHHHHHH | 11.61 | 28152594 | |
| 164 | Phosphorylation | FKQQRYLSAPERDQL HHHHHHCCCCCHHHH | 32.61 | 9858576 | |
| 178 | Phosphorylation | LASVLKLTSTQVKIW HHHHHHHHHHHHHHH | 28.30 | 30631047 | |
| 179 | Phosphorylation | ASVLKLTSTQVKIWF HHHHHHHHHHHHHHH | 27.55 | 30631047 | |
| 180 | Phosphorylation | SVLKLTSTQVKIWFQ HHHHHHHHHHHHHHH | 31.95 | 30631047 | |
| 225 | Dimethylation | IAVPVLVRDGKPCLG EEEEEEEECCCCCCC | 42.68 | - | |
| 225 | Methylation | IAVPVLVRDGKPCLG EEEEEEEECCCCCCC | 42.68 | 30762685 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NKX25_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NKX25_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBX5_HUMAN | TBX5 | physical | 12845333 | |
| TBX5_HUMAN | TBX5 | physical | 11431700 | |
| GATA4_HUMAN | GATA4 | physical | 9312027 | |
| TLE1_HUMAN | TLE1 | physical | 20211142 | |
| HDAC1_HUMAN | HDAC1 | physical | 18851995 | |
| CMTA2_HUMAN | CAMTA2 | physical | 16678093 | |
| KDM6A_HUMAN | KDM6A | physical | 22192413 | |
| JARD2_HUMAN | JARID2 | physical | 15542826 | |
| GATA4_HUMAN | GATA4 | physical | 15542826 | |
| FBX25_HUMAN | FBXO25 | physical | 25725482 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 108900 | Atrial septal defect 7, with or without atrioventricular conduction defects (ASD7) | |||||
| 187500 | Tetralogy of Fallot (TOF) | |||||
| 217095 | Conotruncal heart malformations (CTHM) | |||||
| 225250 | Hypothyroidism, congenital, non-goitrous, 5 (CHNG5) | |||||
| 614432 | Ventricular septal defect 3 (VSD3) | |||||
| 614435 | Hypoplastic left heart syndrome 2 (HLHS2) | |||||
| 271400 | Asplenia, isolated congenital (ICAS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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