PRD14_HUMAN - dbPTM
PRD14_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRD14_HUMAN
UniProt AC Q9GZV8
Protein Name PR domain zinc finger protein 14
Gene Name PRDM14
Organism Homo sapiens (Human).
Sequence Length 571
Subcellular Localization Nucleus .
Protein Description Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'..
Protein Sequence MALPRPSEAVPQDKVCYPPESSPQNLAAYYTPFPSYGHYRNSLATVEEDFQPFRQLEAAASAAPAMPPFPFRMAPPLLSPGLGLQREPLYDLPWYSKLPPWYPIPHVPREVPPFLSSSHEYAGASSEDLGHQIIGGDNESGPCCGPDTLIPPPPADASLLPEGLRTSQLLPCSPSKQSEDGPKPSNQEGKSPARFQFTEEDLHFVLYGVTPSLEHPASLHHAISGLLVPPDSSGSDSLPQTLDKDSLQLPEGLCLMQTVFGEVPHFGVFCSSFIAKGVRFGPFQGKVVNASEVKTYGDNSVMWEIFEDGHLSHFIDGKGGTGNWMSYVNCARFPKEQNLVAVQCQGHIFYESCKEIHQNQELLVWYGDCYEKFLDIPVSLQVTEPGKQPSGPSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCKRSFEKRDRLRIHILHVHEKHRPHKCSTCGKCFSQSSSLNKHMRVHSGDRPYQCVYCTKRFTASSILRTHIRQHSGEKPFKCKYCGKSFASHAAHDSHVRRSHKEDDGCSCSICGKIFSDQETFYSHMKFHEDY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationSPQNLAAYYTPFPSY
CCCCCCHHCCCCCCC		11.41-
30PhosphorylationPQNLAAYYTPFPSYG
CCCCCHHCCCCCCCC		11.83-
39PhosphorylationPFPSYGHYRNSLATV
CCCCCCCCHHCCHHH		13.71-
79PhosphorylationRMAPPLLSPGLGLQR
CCCCCCCCCCCCCCC		25.3019664995
90PhosphorylationGLQREPLYDLPWYSK
CCCCCCCCCCCCHHC		26.5824043423
95PhosphorylationPLYDLPWYSKLPPWY
CCCCCCCHHCCCCCC		8.2524043423
96PhosphorylationLYDLPWYSKLPPWYP
CCCCCCHHCCCCCCC		24.6924043423
166PhosphorylationLLPEGLRTSQLLPCS
HCCCCCCCCCCEECC		26.3521406692
167PhosphorylationLPEGLRTSQLLPCSP
CCCCCCCCCCEECCC		16.6421406692
173PhosphorylationTSQLLPCSPSKQSED
CCCCEECCCCCCCCC		30.2119664994
175PhosphorylationQLLPCSPSKQSEDGP
CCEECCCCCCCCCCC		27.3421406692
191PhosphorylationPSNQEGKSPARFQFT
CCCCCCCCCCCEEEC		34.3519664995
272PhosphorylationHFGVFCSSFIAKGVR
CCHHHHHHHHHCCCE		23.1224719451
387UbiquitinationLQVTEPGKQPSGPSE
EEECCCCCCCCCCCH		70.52-
414PhosphorylationKVFTYKYYRDKHLKY
CEEEEEEECCCCCCC		14.26-
502PhosphorylationTKRFTASSILRTHIR
CCCEEHHHHHHHHHH		24.1524719451
512PhosphorylationRTHIRQHSGEKPFKC
HHHHHHHCCCCCEEC		40.0722210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRD14_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRD14_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRD14_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BEX2_HUMANBEX2physical
25416956
ATPF2_HUMANATPAF2physical
25416956
HEXI2_HUMANHEXIM2physical
25416956
TTC32_HUMANTTC32physical
25416956
TEKT4_HUMANTEKT4physical
25416956
TGO1_HUMANMIA3physical
25416956
PKHF2_HUMANPLEKHF2physical
21516116
ATPF2_HUMANATPAF2physical
21516116
EZH2_HUMANEZH2physical
23280602
EED_HUMANEEDphysical
23280602
SUZ12_HUMANSUZ12physical
23280602
MTG8R_HUMANCBFA2T2physical
28514442
MTG8_HUMANRUNX1T1physical
28514442
STRP2_HUMANSTRIP2physical
28514442
PRDM6_HUMANPRDM6physical
28514442
MTG16_HUMANCBFA2T3physical
28514442
STRP1_HUMANSTRIP1physical
28514442
CT2NL_HUMANCTTNBP2NLphysical
28514442
STRN3_HUMANSTRN3physical
28514442
STRN4_HUMANSTRN4physical
28514442
STRN_HUMANSTRNphysical
28514442
SLMAP_HUMANSLMAPphysical
28514442
CTTB2_HUMANCTTNBP2physical
28514442
PHOCN_HUMANMOB4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRD14_HUMAN

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Related Literatures of Post-Translational Modification

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