PRDM6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDM6_HUMAN
• UniProt AC: Q9NQX0
• Protein Name: Putative histone-lysine N-methyltransferase PRDM6
• Gene Name: PRDM6
• Organism: Homo sapiens (Human).
• Sequence Length: 595
• Subcellular Localization: Nucleus .
• Protein Description: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression..
• Protein Sequence: MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGPLKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAAAAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLAPTTQQRSVVFPQTPCSRNFSLLDKSGPIESGFNQINVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLNNHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KPGDPGGSAFLKVDP CCCCCCCCCCEECCH	23.05	-
45	Phosphorylation	SGAAGLLSAPQPLQP CCCCCCCCCCCCCCC	42.84	-
68	Phosphorylation	RAEPPPDSLRPRPAS CCCCCCCCCCCCCCC	31.86	23663014
161	Methylation	GGGGGEGRGAPRFRC CCCCCCCCCCCCCCC	33.52	115488675
409	Ubiquitination	QPFNKSSKLAPTTQQ CCCCCCCCCCCCCCC	56.62	29967540
456	Phosphorylation	KNQRVLASPTSTSQL CCCEEEECCCCHHHH	25.26	28348404
458	Phosphorylation	QRVLASPTSTSQLHS CEEEECCCCHHHHCH	41.99	28348404
459	Phosphorylation	RVLASPTSTSQLHSE EEEECCCCHHHHCHH	29.46	28348404
460	Phosphorylation	VLASPTSTSQLHSEF EEECCCCHHHHCHHC	23.99	28348404
461	Phosphorylation	LASPTSTSQLHSEFS EECCCCHHHHCHHCC	30.43	28348404
550	Phosphorylation	TLNNHIRTHTGEKPF HHCCCHHHCCCCCCC	24.16	23312004
552	Phosphorylation	NNHIRTHTGEKPFKC CCCHHHCCCCCCCCC	46.56	29496963
588	Phosphorylation	ECKPITESPESIEVD CCCCCCCCCCCCCCC	25.89	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDM6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDM6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDM6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDM6_HUMAN	PRDM6	physical	16537907
CBX1_HUMAN	CBX1	physical	16537907
HDAC1_HUMAN	HDAC1	physical	16537907
HDAC2_HUMAN	HDAC2	physical	16537907
HDAC3_HUMAN	HDAC3	physical	16537907
EP300_HUMAN	EP300	physical	16537907
H31_HUMAN	HIST1H3A	physical	16537907

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.