ATX10_HUMAN - dbPTM
ATX10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATX10_HUMAN
UniProt AC Q9UBB4
Protein Name Ataxin-10
Gene Name ATXN10
Organism Homo sapiens (Human).
Sequence Length 475
Subcellular Localization Cytoplasm, perinuclear region .
Protein Description Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis..
Protein Sequence MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Methylation---MAAPRPPPARLS
---CCCCCCCCCCCC		52.19-
10MethylationAPRPPPARLSGVMVP
CCCCCCCCCCCCCCC		34.85-
12PhosphorylationRPPPARLSGVMVPAP
CCCCCCCCCCCCCCC		24.6429255136
15SulfoxidationPARLSGVMVPAPIQD
CCCCCCCCCCCCHHH		3.2221406390
29UbiquitinationDLEALRALTALFKEQ
HHHHHHHHHHHHHHH		2.0221890473
30PhosphorylationLEALRALTALFKEQR
HHHHHHHHHHHHHHH		21.96-
34UbiquitinationRALTALFKEQRNRET
HHHHHHHHHHHCCCC		54.5133845483
34AcetylationRALTALFKEQRNRET
HHHHHHHHHHHCCCC		54.5125953088
34MalonylationRALTALFKEQRNRET
HHHHHHHHHHHCCCC		54.5126320211
41PhosphorylationKEQRNRETAPRTIFQ
HHHHCCCCCCHHHHH		38.4325072903
45PhosphorylationNRETAPRTIFQRVLD
CCCCCCHHHHHHHHH		25.6925072903
55UbiquitinationQRVLDILKKSSHAVE
HHHHHHHHHCCCHHH		51.4421890473
55UbiquitinationQRVLDILKKSSHAVE
HHHHHHHHHCCCHHH		51.4421906983
55AcetylationQRVLDILKKSSHAVE
HHHHHHHHHCCCHHH		51.4425953088
56UbiquitinationRVLDILKKSSHAVEL
HHHHHHHHCCCHHHH		54.4633845483
77PhosphorylationQVENLASSLQLITEC
HHHHHHHHHHHHHHH		17.9621857149
82PhosphorylationASSLQLITECFRCLR
HHHHHHHHHHHHHHH		34.9821857149
96PhosphorylationRNACIECSVNQNSIR
HHHHHHCCCCCHHCC		16.0029978859
138UbiquitinationAFRCGLQFLGNIASR
HHHHHHHHHHHHHHC		13.0221890473
173UbiquitinationLNHPDKKIVAYSSMI
HCCCCHHHHHHHHHH		2.3621890473
173UbiquitinationLNHPDKKIVAYSSMI
HCCCCHHHHHHHHHH		2.3621890473
189UbiquitinationFTSLNHERMKELEEN
HHCCCHHHHHHHHHH		33.6423503661
198UbiquitinationKELEENLNIAIDVID
HHHHHHHHHHHHHHH		32.9723000965
198NeddylationKELEENLNIAIDVID
HHHHHHHHHHHHHHH		32.9732015554
198UbiquitinationKELEENLNIAIDVID
HHHHHHHHHHHHHHH		32.9721890473
220UbiquitinationSEWPFLIITDLFLKS
CCCCEEEEEHHHHCC		2.3923000965
221PhosphorylationEWPFLIITDLFLKSP
CCCEEEEEHHHHCCH		21.47-
224UbiquitinationFLIITDLFLKSPELV
EEEEEHHHHCCHHHH		10.0621890473
224UbiquitinationFLIITDLFLKSPELV
EEEEEHHHHCCHHHH		10.0623000965
237UbiquitinationLVQAMFPKLNNQERV
HHHHHCCCCCCHHHH		53.2121906983
253UbiquitinationLLDLMIAKITSDEPL
HHHHHHHHHCCCCCC		35.2823503661
262UbiquitinationTSDEPLTKDDIPVFL
CCCCCCCCCCCCHHH		62.1721906983
262NeddylationTSDEPLTKDDIPVFL
CCCCCCCCCCCCHHH		62.1732015554
281UbiquitinationLIASTFVDQCKTVLK
HHHHHHHHHHHHHHH		43.9222053931
283GlutathionylationASTFVDQCKTVLKLA
HHHHHHHHHHHHHHH		3.2722555962
284UbiquitinationSTFVDQCKTVLKLAS
HHHHHHHHHHHHHHC		35.7123000965
2842-HydroxyisobutyrylationSTFVDQCKTVLKLAS
HHHHHHHHHHHHHHC		35.71-
288UbiquitinationDQCKTVLKLASEEPP
HHHHHHHHHHCCCCC		37.3623000965
307UbiquitinationALATIRLLDVLCEMT
HHHHHHHHHHHHHHC		2.8421890473
307UbiquitinationALATIRLLDVLCEMT
HHHHHHHHHHHHHHC		2.8421890473
320UbiquitinationMTVNTELLGYLQVFP
HCCCHHHHHHHHHCC		3.2732015554
345UbiquitinationRVIHVAGKETTNIFS
HHHHHCCCCCCCCHH		41.9921906983
364PhosphorylationVRAEGDISNVANGFK
EEECCCHHHHHHHHH		29.9621712546
371UbiquitinationSNVANGFKSHLIRLI
HHHHHHHHHHHHHHH		38.0621906983
374UbiquitinationANGFKSHLIRLIGNL
HHHHHHHHHHHHHHH		2.9222053931
374UbiquitinationANGFKSHLIRLIGNL
HHHHHHHHHHHHHHH		2.9221890473
382GlutathionylationIRLIGNLCYKNKDNQ
HHHHHHHHHCCCCCC		5.4322555962
384AcetylationLIGNLCYKNKDNQDK
HHHHHHHCCCCCCCC		57.4325953088
384UbiquitinationLIGNLCYKNKDNQDK
HHHHHHHCCCCCCCC		57.4332015554
387UbiquitinationNLCYKNKDNQDKVNE
HHHHCCCCCCCCCHH		68.3721890473
387UbiquitinationNLCYKNKDNQDKVNE
HHHHCCCCCCCCCHH		68.3721890473
388UbiquitinationLCYKNKDNQDKVNEL
HHHCCCCCCCCCHHC		54.2621890473
388UbiquitinationLCYKNKDNQDKVNEL
HHHCCCCCCCCCHHC		54.2621890473
395UbiquitinationNQDKVNELDGIPLIL
CCCCCHHCCCCCEEE		6.5332142685
403UbiquitinationDGIPLILDNCNISDS
CCCCEEEECCCCCCC		51.1227667366
426PhosphorylationIYAIRNLTEDNSQNQ
HHHHHHCCCCCCCCH		44.8620860994
430PhosphorylationRNLTEDNSQNQDLIA
HHCCCCCCCCHHHHH		42.7126055452
438UbiquitinationQNQDLIAKMEEQGLA
CCHHHHHHHHHCCCC		39.5921906983
448PhosphorylationEQGLADASLLKKVGF
HCCCCCHHHHHHHCC		34.4822199227
451UbiquitinationLADASLLKKVGFEVE
CCCHHHHHHHCCEEE		51.1921906983
452UbiquitinationADASLLKKVGFEVEK
CCHHHHHHHCCEEEE		47.7821906983
459UbiquitinationKVGFEVEKKGEKLIL
HHCCEEEECCCEEEE		71.8521906983
467UbiquitinationKGEKLILKSTRDTPK
CCCEEEEEECCCCCC		42.6727667366
467AcetylationKGEKLILKSTRDTPK
CCCEEEEEECCCCCC		42.6725953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
12SPhosphorylationKinaseAURKBQ96GD4
GPS
77SPhosphorylationKinasePLK1P53350
PSP
82TPhosphorylationKinasePLK1P53350
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATX10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATX10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYPT1_HUMANPPP1R12Aphysical
16498633
GBB1_HUMANGNB1physical
16498633
GBB2_HUMANGNB2physical
16498633
FINC_HUMANFN1physical
16498633
RT16_HUMANMRPS16physical
16498633
GLSK_HUMANGLSphysical
16498633
GOGA1_HUMANGOLGA1physical
16498633
ABCA1_HUMANABCA1physical
16498633
HSP7C_HUMANHSPA8physical
22863883
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
603516Spinocerebellar ataxia 10 (SCA10)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATX10_HUMAN

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Related Literatures of Post-Translational Modification

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