GBG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBG3_HUMAN
• UniProt AC: P63215
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
• Gene Name: GNG3
• Organism: Homo sapiens (Human).
• Sequence Length: 75
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKGETPVNSTMS ---CCCCCCCCCCCC	41.00	20886841
9	Phosphorylation	KGETPVNSTMSIGQA CCCCCCCCCCCHHHH	26.22	22199227
10	Phosphorylation	GETPVNSTMSIGQAR CCCCCCCCCCHHHHH	15.10	22199227
12	Phosphorylation	TPVNSTMSIGQARKM CCCCCCCCHHHHHHH	24.53	22199227
24	"N6,N6-dimethyllysine"	RKMVEQLKIEASLCR HHHHHHHHHHHHHHC	37.89	-
24	Methylation	RKMVEQLKIEASLCR HHHHHHHHHHHHHHC	37.89	23644510
33	Ubiquitination	EASLCRIKVSKAAAD HHHHHCHHHCHHHHH	22.54	32015554
36	Ubiquitination	LCRIKVSKAAADLMT HHCHHHCHHHHHHHH	45.06	32142685
72	Methylation	FREKKFFCALL---- CHHHCCHHCCC----	2.69	-
72	Geranylgeranylation	FREKKFFCALL---- CHHHCCHHCCC----	2.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNB5_HUMAN	GNB5	physical	8636150
GBB1_HUMAN	GNB1	physical	8636150
GBB2_HUMAN	GNB2	physical	8636150
GBB3_HUMAN	GNB3	physical	8636150
GBB4_HUMAN	GNB4	physical	8636150
GBB1_HUMAN	GNB1	physical	19168127
GBB2_HUMAN	GNB2	physical	19168127
GBB3_HUMAN	GNB3	physical	19168127
GNAT2_HUMAN	GNAT2	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
GNAO_HUMAN	GNAO1	physical	28514442
GNA13_HUMAN	GNA13	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
GNAZ_HUMAN	GNAZ	physical	28514442
GNA11_HUMAN	GNA11	physical	28514442
FLNC_HUMAN	FLNC	physical	28514442
GBB1_HUMAN	GNB1	physical	28514442
GNAI2_HUMAN	GNAI2	physical	28514442
GNAI1_HUMAN	GNAI1	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.