GNAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAT2_HUMAN
• UniProt AC: P19087
• Protein Name: Guanine nucleotide-binding protein G(t) subunit alpha-2
• Gene Name: GNAT2
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase..
• Protein Sequence: MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMPPELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSGASAED ------CCCCCCHHH	34.48	-
3	Phosphorylation	-----MGSGASAEDK -----CCCCCCHHHH	29.86	24719451
6	Phosphorylation	--MGSGASAEDKELA --CCCCCCHHHHHHH	35.40	24719451
17	Acetylation	KELAKRSKELEKKLQ HHHHHHHHHHHHHHH	71.05	30588951
21	Acetylation	KRSKELEKKLQEDAD HHHHHHHHHHHHHHH	71.99	30588957
35	Acetylation	DKEAKTVKLLLLGAG HHHHHHHHHHHHCCC	38.35	7219281
44	Phosphorylation	LLLGAGESGKSTIVK HHHCCCCCCCCHHHH	51.07	20873877
46	Ubiquitination	LGAGESGKSTIVKQM HCCCCCCCCHHHHEE	54.42	21890473
47	Phosphorylation	GAGESGKSTIVKQMK CCCCCCCCHHHHEEE	27.22	20873877
48	Phosphorylation	AGESGKSTIVKQMKI CCCCCCCHHHHEEEE	33.02	29514088
51	Ubiquitination	SGKSTIVKQMKIIHQ CCCCHHHHEEEEECC	40.60	21906983
95	Phosphorylation	MTTLGIDYAEPSCAD HHHCCCCCCCCCCCC	15.79	-
178	ADP-ribosylation	EQDVLRSRVKTTGII HHHHHHHHHCCCCEE	27.76	-
178	ADP-ribosylation	EQDVLRSRVKTTGII HHHHHHHHHCCCCEE	27.76	-
192	Ubiquitination	IETKFSVKDLNFRMF EEEEEEECCCCEEEE	56.13	-
206	Phosphorylation	FDVGGQRSERKKWIH EECCCCCCCCHHHHH	33.59	23401153
271	Ubiquitination	IVLFLNKKDLFEEKI HHHHHCCHHHHHHHH	59.60	-
321	Phosphorylation	KDVKEIYSHMTCATD CCHHHHHHHCCCCCC	16.67	22210691
324	Phosphorylation	KEIYSHMTCATDTQN HHHHHHCCCCCCCCC	8.12	30576142
327	Phosphorylation	YSHMTCATDTQNVKF HHHCCCCCCCCCCCC	41.55	22210691
329	Phosphorylation	HMTCATDTQNVKFVF HCCCCCCCCCCCCHH	20.07	30576142
351	ADP-ribosylation	IKENLKDCGLF---- HHHHHCCCCCC----	4.95	-
351	ADP-ribosylation	IKENLKDCGLF---- HHHHHCCCCCC----	4.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
U119A_HUMAN	UNC119	physical	26186194
U119B_HUMAN	UNC119B	physical	26186194
ACSL3_HUMAN	ACSL3	physical	26186194
ACSL4_HUMAN	ACSL4	physical	26186194
SNX1_HUMAN	SNX1	physical	26186194
SNX2_HUMAN	SNX2	physical	26186194
SNX5_HUMAN	SNX5	physical	26186194
VP13A_HUMAN	VPS13A	physical	26186194
OCAD1_HUMAN	OCIAD1	physical	26186194
EPHA4_HUMAN	EPHA4	physical	26186194
ARMX3_HUMAN	ARMCX3	physical	26186194
ACSL4_HUMAN	ACSL4	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
SNX5_HUMAN	SNX5	physical	28514442
U119A_HUMAN	UNC119	physical	28514442
ACSL3_HUMAN	ACSL3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613856: Achromatopsia 4 (ACHM4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.