GNB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNB5_HUMAN
• UniProt AC: O14775
• Protein Name: Guanine nucleotide-binding protein subunit beta-5
• Gene Name: GNB5
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Subcellular Localization: Membrane .
• Protein Description: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. [PubMed: 27677260 May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity]
• Protein Sequence: MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	RALRPVFKKSQQLSY HHHHHHHCHHHHHHH		30588987
58	Sumoylation	NETLASLKSEAESLK CHHHHHHHHHHHHHC		-
58	Sumoylation	NETLASLKSEAESLK CHHHHHHHHHHHHHC		-
58	Ubiquitination	NETLASLKSEAESLK CHHHHHHHHHHHHHC		-
63	Phosphorylation	SLKSEAESLKGKLEE HHHHHHHHHCHHHHH		28060719
65	Ubiquitination	KSEAESLKGKLEEER HHHHHHHCHHHHHHH		-
74	Ubiquitination	KLEEERAKLHDVELH HHHHHHHHHCHHHHH		-
115	Ubiquitination	VLCMDWCKDKRRIVS EEEEEHHCCCCEEEE		-
117	Ubiquitination	CMDWCKDKRRIVSSS EEEHHCCCCEEEECC		-
158	Phosphorylation	MACAYAPSGCAIACG ECCCCCCCCEEEEEC		24667141
180	Ubiquitination	VYPLTFDKNENMAAK EEEEEECCCCCCCCH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNB5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBG7_HUMAN	GNG7	physical	8636150
MVD1_HUMAN	MVD	physical	16169070
MCM2_HUMAN	MCM2	physical	16169070
RGS7_HUMAN	RGS7	physical	10051672
PHLP_HUMAN	PDCL	physical	19376773
GBG2_HUMAN	GNG2	physical	19376773
RGS7_HUMAN	RGS7	physical	19376773
A4_HUMAN	APP	physical	21832049
PSMD4_HUMAN	PSMD4	physical	21988832
RFA1_HUMAN	RPA1	physical	21988832
GBG2_HUMAN	GNG2	physical	12606627
GBG3_HUMAN	GNG3	physical	12606627
GBG13_HUMAN	GNG13	physical	12606627
RGS11_HUMAN	RGS11	physical	12606627
TCPW_HUMAN	CCT6B	physical	26186194
TCPG_HUMAN	CCT3	physical	26186194
TCPA_HUMAN	TCP1	physical	26186194
PHLP_HUMAN	PDCL	physical	26186194
PFD5_HUMAN	PFDN5	physical	26186194
CSN5_HUMAN	COPS5	physical	26186194
RGS7_HUMAN	RGS7	physical	26186194
DRD2_HUMAN	DRD2	physical	25162404
RGS7_HUMAN	RGS7	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.