RGS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS7_HUMAN
• UniProt AC: P49802
• Protein Name: Regulator of G-protein signaling 7
• Gene Name: RGS7
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Cell membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membran
• Protein Description: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. [PubMed: 10521509]
• Protein Sequence: MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	RTVKSFLSKIPSVFS HHHHHHHHCCCHHCC	26.91	22210691
217	Phosphorylation	TEVDIKKSSRMRNPH CCCCCCHHHCCCCCC	20.41	26074081
218	Phosphorylation	EVDIKKSSRMRNPHK CCCCCHHHCCCCCCC	38.69	26074081
228	Acetylation	RNPHKTRKSVYGLQN CCCCCCCHHHHHCHH	49.89	20167786
229	Phosphorylation	NPHKTRKSVYGLQND CCCCCCHHHHHCHHC	19.79	24076635
239	Phosphorylation	GLQNDIRSHSPTHTP HCHHCHHHCCCCCCC	28.75	25307156
241	Phosphorylation	QNDIRSHSPTHTPTP HHCHHHCCCCCCCCC	32.51	20886841
243	Phosphorylation	DIRSHSPTHTPTPET CHHHCCCCCCCCCCC	41.20	20886841
245	Phosphorylation	RSHSPTHTPTPETKP HHCCCCCCCCCCCCC	31.19	22496350
247	Phosphorylation	HSPTHTPTPETKPPT CCCCCCCCCCCCCCC	34.61	26699800
250	Phosphorylation	THTPTPETKPPTEDE CCCCCCCCCCCCHHH	50.48	26699800
251	Acetylation	HTPTPETKPPTEDEL CCCCCCCCCCCHHHH	47.54	20167786
254	Phosphorylation	TPETKPPTEDELQQQ CCCCCCCCHHHHHHH	65.67	26699800
277	Phosphorylation	DRHRLKMSKVADSLL HHHHHHHHHHHHHHH	23.53	25332170
282	Phosphorylation	KMSKVADSLLSYTEQ HHHHHHHHHHHHHHH	22.82	22210691
285	Phosphorylation	KVADSLLSYTEQYLE HHHHHHHHHHHHHHH	34.99	25332170
287	Phosphorylation	ADSLLSYTEQYLEYD HHHHHHHHHHHHHCC	17.15	22210691
323	Phosphorylation	LEASKEPSQQRVKRW ECCCCCHHHHHHHHH	39.78	-
434	Phosphorylation	YKLMKSDSYPRFIRS HHHHCCCCCCHHHHC	44.09	22817900
457	Phosphorylation	AKKKSGNSMDRRTSF HHHHCCCCCCHHHHH	26.11	23532336
462	Phosphorylation	GNSMDRRTSFEKFAQ CCCCCHHHHHHHHHH	38.37	26307563
463	Phosphorylation	NSMDRRTSFEKFAQN CCCCHHHHHHHHHHH	29.60	26307563

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
434	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAQ_HUMAN	GNAQ	physical	12670932
SNAPN_HUMAN	SNAPIN	physical	12659861
GNAI3_HUMAN	GNAI3	physical	10092682
GNAZ_HUMAN	GNAZ	physical	10092682
GNB5_HUMAN	GNB5	physical	10521509
GNB5_HUMAN	GNB5	physical	10339615
GNB5_HUMAN	GNB5	physical	9789084

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.