RGS11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS11_HUMAN
• UniProt AC: O94810
• Protein Name: Regulator of G-protein signaling 11
• Gene Name: RGS11
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Protein Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form..
• Protein Sequence: MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Acetylation	AQMPHLRKMERVVVS HHCCCHHCCEEEEEC	52.02	7481263
37	Methylation	QDPDQGVKMRSQRLL CCCCCCCCHHHEEEE	35.11	-
175	Phosphorylation	LRAAKQRSKGDRLVI HHHHHHHCCCCEEEE	38.20	-
188	Phosphorylation	VIACQEQTYWLVNRP EEEEEEEEEEECCCC	18.86	27251275
232	Phosphorylation	FHKREIEYFRKALGR HHHHHHHHHHHHHCC	17.85	-
303	Phosphorylation	RVERWGFSFRELLED EEEECCCCHHHHHHC	21.32	24719451
450	Phosphorylation	PSPALLPTPVEPTAA CCCCCCCCCCCCCCC	39.68	26853621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNB5_HUMAN	GNB5	physical	10339615
GNB5_HUMAN	GNB5	physical	9789084

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.