DRD2_HUMAN - dbPTM
DRD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRD2_HUMAN
UniProt AC P14416
Protein Name D(2) dopamine receptor
Gene Name DRD2
Organism Homo sapiens (Human).
Sequence Length 443
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase..
Protein Sequence MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5N-linked_Glycosylation---MDPLNLSWYDDD
---CCCCCCCCCCHH		37.10UniProtKB CARBOHYD
17N-linked_GlycosylationDDDLERQNWSRPFNG
CHHHHHCCCCCCCCC		44.93UniProtKB CARBOHYD
19PhosphorylationDLERQNWSRPFNGSD
HHHHCCCCCCCCCCC		37.3124719451
23N-linked_GlycosylationQNWSRPFNGSDGKAD
CCCCCCCCCCCCCCC		52.31UniProtKB CARBOHYD
134 (in isoform 2)Phosphorylation-18.62-
134PhosphorylationAISIDRYTAVAMPML
CCCCCHHHHHHHHHH		18.6220160122
144PhosphorylationAMPMLYNTRYSSKRR
HHHHHHCCCCCCCCC		19.8920160122
147PhosphorylationMLYNTRYSSKRRVTV
HHHCCCCCCCCCEEE		26.5420160122
148PhosphorylationLYNTRYSSKRRVTVM
HHCCCCCCCCCEEEE		22.6520160122
225PhosphorylationRRRKRVNTKRSSRAF
HHHHHCCCHHHHHHH		25.6120160122
225 (in isoform 2)Phosphorylation-25.61-
228PhosphorylationKRVNTKRSSRAFRAH
HHCCCHHHHHHHHHH		26.2317869243
228 (in isoform 2)Phosphorylation-26.23-
229PhosphorylationRVNTKRSSRAFRAHL
HCCCHHHHHHHHHHH		31.4917869243
229 (in isoform 2)Phosphorylation-31.49-
295PhosphorylationSPPERTRYSPIPPSH
CCCCCCCCCCCCCCC		20.4128111955
296PhosphorylationPPERTRYSPIPPSHH
CCCCCCCCCCCCCCC		17.0528111955
301PhosphorylationRYSPIPPSHHQLTLP
CCCCCCCCCCCCCCC		28.3928111955
306PhosphorylationPPSHHQLTLPDPSHH
CCCCCCCCCCCCCCC		29.6728111955
321PhosphorylationGLHSTPDSPAKPEKN
CCCCCCCCCCCCCCC		28.14-
324MethylationSTPDSPAKPEKNGHA
CCCCCCCCCCCCCCC		58.03-
325 (in isoform 2)Phosphorylation-60.96-
332MethylationPEKNGHAKDHPKIAK
CCCCCCCCCCHHHHE		51.39-
336MethylationGHAKDHPKIAKIFEI
CCCCCCHHHHEEEEE		52.45-
354PhosphorylationPNGKTRTSLKTMSRR
CCCCCHHHHHHHHHH		25.2810692483
359PhosphorylationRTSLKTMSRRKLSQQ
HHHHHHHHHHHHHHH		33.88-
443S-palmitoylationAFLKILHC-------
HHHHHHCC-------		5.5226535572
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
228SPhosphorylationKinasePKCAP17252
PSP
229SPhosphorylationKinasePKCAP17252
PSP
321SPhosphorylationKinaseCDK5Q00535
PSP
321SPhosphorylationKinaseCDK5P49615
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLIC6_HUMANCLIC6physical
14499480
NEB2_HUMANPPP1R9Bphysical
10391935
NCS1_HUMANNCS1physical
12351722
E41L1_HUMANEPB41L1physical
12181426
FLNA_HUMANFLNAphysical
12181426
KCNJ3_HUMANKCNJ3physical
12297500
KCNJ6_HUMANKCNJ6physical
12297500
KCNJ5_HUMANKCNJ5physical
12297500
PAWR_HUMANPAWRphysical
16051151
MSRA_HUMANMSRAphysical
28514442
COL12_HUMANCOLEC12physical
28514442
WIPI4_HUMANWDR45physical
28514442
NFIP1_HUMANNDFIP1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
159900Dystonia 11 (DYT11)
Kegg Drug
D00059 Levodopa (JP16/USP/INN); Dopar (TN)
D00136 Haloperidol (JP16/USP/INN); Haldol (TN)
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00283 Clozapine (JAN/USP/INN); Clozaril (TN)
D00308 Droperidol (JP16/USP/INN); Droleptan (TN); Inapsine (TN)
D00373 Thioridazine (USP/INN); Mellaril-S (TN)
D00374 Tiotixene (JAN); Thiothixene (USP); Navane (TN)
D00390 Triflupromazine (USP/INN); Vesprin (TN)
D00403 Levomepromazine (USAN/INN); Methotrimeprazine (USP); Levoprome (TN)
D00426 Risperidone (JP16/USAN/INN); Risperdal (TN)
D00454 Olanzapine (JAN/USAN/INN); Zyprexa (TN)
D00458 Quetiapine fumarate (JP16/USAN); Seroquel (TN)
D00479 Prochlorperazine maleate (JP16/USP); Compazine (TN)
D00493 Prochlorperazine (JAN/USP/INN); Compro (TN)
D00502 Pergolide mesilate (JAN); Pergolide mesylate (USP); Permax (TN)
D00503 Perphenazine (JP16/USP/INN); Trilafon (TN)
D00559 Pramipexole hydrochloride hydrate (JAN); Pramipexole hydrochloride (USAN); Mirapex (TN)
D00560 Pimozide (JP16/USP/INN); Orap (TN)
D00561 Sertindole (USAN/INN); SerLect (TN)
D00633 Dopamine hydrochloride (JP16/USP); Actopamin (TN); Intropin (TN)
D00679 Ergotamine tartrate (JP16/USP); Ergomar (TN)
D00680 Methylergometrine maleate (JP16); Methylergonovine maleate (USP); Methergine (TN)
D00726 Metoclopramide (JP16/INN); Elieten (TN); Terperan (TN)
D00780 Bromocriptine mesilate (JP16); Bromocriptine mesylate (USP); Parlodel (TN)
D00784 Ropinirole hydrochloride (JAN/USAN); Requip (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D00791 Fluphenazine hydrochloride (JAN/USP); Prolixin (TN)
D00792 Fluphenazine enanthate (JP16/USP); Prolixin enanthate (TN)
D00793 Fluphenazine decanoate (JAN/USP); Prolixin decanoate (TN)
D00794 Loxapine succinate (USP); Loxitane (TN)
D00796 Molindone hydrochloride (USP); Moban (TN)
D00797 Promazine hydrochloride (USP); Sparine (TN)
D00798 Thioridazine hydrochloride (JP16/USP); Mellaril (TN)
D00799 Trifluoperazine hydrochloride (JAN/USP); Stelazine (TN)
D00800 Triflupromazine hydrochloride (JAN/USP); Vesprin (TN)
D00987 Cabergoline (JAN/USAN/INN); Cabaser (TN); Dostinex (TN)
D01044 Flupentixol (INN); Flupenthixol; Depixol (TN)
D01051 Spiperone (JAN/USAN); Spiropitan (TN)
D01101 Bromperidol (JAN/USAN/INN); Impromen (TN)
D01105 Moperone hydrochloride (JAN); Luvatren (TN)
D01163 Ergometrine maleate (JP16); Ergonovine maleate (USP); Ergometrine (TN)
D01164 Aripiprazole (JAN/USAN/INN); Abilify (TN)
D01176 Blonanserin (JAN/INN); AD 5423
D01226 Sulpiride (JP16/USAN/INN); Dogmatyl (TN)
D01321 Zotepine (JAN/INN); Setous (TN)
D01348 Terguride (JAN/INN); Teluron (TN)
D01447 Thioproperazine mesilate (JAN); Thioproperazine mesylate
D01448 Trifluoperazine maleate (JAN); Trifluoperazine (TN)
D01462 Lisuride maleate (JAN)
D01468 Nemonapride (JAN/INN); Emilace (TN)
D01477 Opipramol hydrochloride (JAN/USAN); Insidon (TN)
D01482 Pipamperone hydrochloride (JAN)
D01485 Propericiazine (JAN); Periciazine; Neuleptil (TN)
D01505 Talipexole hydrochloride (JAN); Domin (TN)
D01520 Levomepromazine hydrochloride (JAN/USAN); Nozinan (TN)
D01522 Tiapride hydrochloride (JP16); Gramalil (TN)
D01548 Mosapramine hydrochloride (JAN); Cremin (TN)
D01742 Clebopride malate (JP16); Clast (TN)
D01745 Domperidone (JP16/USAN/INN); Motilium (TN)
D01898 Haloperidol decanoate (JAN/USAN); Halomonth (TN)
D01939 Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN); Geodon (TN)
D02004 Apomorphine hydrochloride hydrate (JAN); Apomorphine hydrochloride (USP); Apokyn (TN); Ixense (TN);
D02022 Prochlorperazine mesilate (JAN); Prochlorperazine dimethanesulfonate; Novamin (TN)
D02035 Timiperone (JAN); Tolopelon (TN)
D02037 Perphenazine maleate (JP16); PZC (TN)
D02100 Ziprasidone mesylate (USAN); Ziprasidone mesylate hydrate; Geodon (TN)
D02163 Fluphenazine maleate (JAN); Flumezin (TN)
D02208 Sultopride hydrochloride (JAN); Sultopride monohydrochloride; Barnetil (TN)
D02211 Dihydroergotamine mesilate (JP16); Dihydroergotamine mesylate (USP); Migranal (TN)
D02213 Metoclopramide hydrochloride (JAN); Metoclopramide dihydrochloride monohydrate; Primperan (TN); Regl
D02236 Flupentixol dihydrochloride (JAN)
D02248 Levomepromazine maleate (JP16/USAN); Hirnamin (TN)
D02340 Loxapine (USAN/INN); Adasuve (TN)
D02371 Clocapramine hydrochloride hydrate (JP16); Clofekton (TN)
D02372 Perospirone hydrochloride hydrate (JAN); Lullan (TN)
D02605 Methoxypromazine maleate
D02609 Prochlorperazine edisylate (USP); Compazine syrup (TN)
D02612 Thiothixene hydrochloride (USP); Thiothixene dihydrochloride dihydrate; Tiotixene dihydrochloride; T
D02613 Clopenthixol (USAN)
D02622 Pipamperone (USAN/INN); Floropipamide
D02623 Moperone (INN)
D02625 Trifluperidol (USAN/INN); Triperidol (TN)
D02626 Bromperidol decanoate (USAN)
D02641 Butaclamol hydrochloride (USAN)
D02666 Iloperidone (USAN/INN); Fanapt (TN)
D02670 Mazapertine succinate (USAN)
D02676 Oxiperomide (USAN/INN)
D02681 Piquindone hydrochloride (USAN)
D02682 Remoxipride (USAN)
D02683 Remoxipride hydrochloride (USAN)
D02688 Tiospirone hydrochloride (USAN)
D02995 Asenapine maleate (USAN); Saphris (TN)
D03165 Bromocriptine (USAN/INN)
D03214 Aplindore fumarate (USAN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03494 Ciladopa hydrochloride (USAN); Tremerase (TN)
D03534 Clebopride (USAN); Cleboril (TN)
D03556 Zuclopenthixol (INN); Clopixol (TN)
D03891 Dopexamine (USAN/INN)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04038 Perphenazine fendizoate (JAN); PZC (TN)
D04488 Ibopamine (USAN/INN)
D04693 Lergotrile (USAN/INN)
D04694 Lergotrile mesylate (USAN)
D04820 Lurasidone hydrochloride (JAN/USAN); SM 13496; Latuda (TN)
D04965 Perphenazine hydrochloride; Perphenazine dihydrochloride; PZC intramuscular injection (TN)
D05008 Metoclopramide hydrochloride (USAN); Metoclopramide hydrochloride monohydrate; Clopra (TN); Reglan (
D05010 Metopimazine (USAN/INN)
D05339 Paliperidone (JAN/USAN/INN); Invega (TN)
D05340 Paliperidone palmitate (JAN/USAN)
D05575 Pramipexole (USAN/INN)
D05677 Quinelorane hydrochloride (USAN)
D05682 Quinpirole hydrochloride (USAN)
D05690 Raclopride C11 (USP)
D05768 Rotigotine (JAN/USAN/INN); Neupro (TN)
D05832 Sibenadet hydrochloride (USAN); Viozan (TN)
D06566 Bifeprunox (USAN/INN); OPC-4392
D06567 Bifeprunox mesylate (USAN)
D06623 Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate
D07101 Bromopride (INN); Movipride (TN)
D07102 Alizapride (INN); Plitican (TN)
D07217 Quinagolide (INN/BAN)
D07305 Piribedil (INN); Trivastal (TN)
D07312 Levosulpiride (INN); Levopraid (TN)
D07460 Apomorphine (BAN); Uprima (TN)
D07563 Alizapride hydrochloride; Plitican (TN)
D07718 Clocapramine (INN)
D07837 Dihydroergotamine (INN); Neomigran (TN)
D07838 Dihydroergotamine tartrate; Divegal (TN)
D07868 Domperidone maleate; Domperidone (TN)
D07870 Dopamine (INN); Medopa (TN)
D07905 Ergometrine (INN)
D07906 Ergotamine (INN)
D07976 Flupentixol decanoate; Fluanxol depot (TN)
D07977 Fluphenazine (INN); Moditen (TN)
D08035 Haloperidol lactate; Haldol (TN)
D08057 Ibopamine hydrochloride; Scandine (TN)
D08132 Lisuride (INN)
D08148 Loxapine hydrochloride; Desconex (TN)
D08207 Methylergometrine (INN); Ergotyl (TN)
D08226 Molindone (INN)
D08235 Mosapramine (INN)
D08297 Opipramol (INN); Opipramol dura (TN)
D08339 Pergolide (INN); Permax (TN)
D08341 Perphenazine decanoate; Trilafon dekanoat (TN)
D08342 Perphenazine enantate; Perphenazine enanthate; Trilafon (TN)
D08456 Quetiapine (INN); Norsic (TN)
D08457 Quinagolide hydrochloride (BAN); Norprolac (TN)
D08489 Ropinirole (USAN/INN); Ropitor (TN)
D08549 Sultopride (INN)
D08558 Talipexole (INN)
D08585 Thioproperazine (INN)
D08590 Tiapride (INN); Tiapridal (TN)
D08636 Trifluoperazine (INN); Apo-trifluoperazine (TN)
D08637 Trifluperidol hydrochloride; Triperidol (TN)
D08687 Ziprasidone (INN); Zipradon (TN)
D08691 Zuclopenthixol acetate; Cisordinol-acutard (TN)
D08692 Zuclopenthixol decanoate; Clopixol depot (TN)
D08693 Zuclopenthixol dihydrochloride; Clopixol (TN)
D09366 Pardoprunox hydrochloride (USAN)
D09397 Pardoprunox (USAN/INN)
D09819 Chlorpromazine tannate (JAN)
D09876 Cariprazine hydrochloride (JAN/USAN)
D09953 Pridopidine (USAN/INN)
D09954 Pridopidine hydrochloride (USAN)
D09997 Cariprazine (USAN/INN)
D10309 Brexpiprazole (USAN/INN)
D10355 Aripiprazole cavoxil (USAN)
D10364 Aripiprazole lauroxil (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRD2_HUMAN

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