| UniProt ID | KCNJ3_HUMAN | |
|---|---|---|
| UniProt AC | P48549 | |
| Protein Name | G protein-activated inward rectifier potassium channel 1 | |
| Gene Name | KCNJ3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 501 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.. | |
| Protein Sequence | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | RRKFGDDYQVVTTSS HHHHCCCEEEEEECC | 27642862 | ||
| 16 | Phosphorylation | GDDYQVVTTSSSGSG CCCEEEEEECCCCCC | 25954137 | ||
| 18 | Phosphorylation | DYQVVTTSSSGSGLQ CEEEEEECCCCCCCC | 25954137 | ||
| 19 | Phosphorylation | YQVVTTSSSGSGLQP EEEEEECCCCCCCCC | 25954137 | ||
| 22 | Phosphorylation | VTTSSSGSGLQPQGP EEECCCCCCCCCCCC | 25954137 | ||
| 62 | Phosphorylation | VQHGNLGSETSRYLS CCCCCCCHHHHHHHH | - | ||
| 65 | Phosphorylation | GNLGSETSRYLSDLF CCCCHHHHHHHHHHH | - | ||
| 69 | Phosphorylation | SETSRYLSDLFTTLV HHHHHHHHHHHHHHH | 17924679 | ||
| 73 | Phosphorylation | RYLSDLFTTLVDLKW HHHHHHHHHHHHHHH | 17924679 | ||
| 119 | N-linked_Glycosylation | LNKAHVGNYTPCVAN CCCCCCCCCCCCEEE | 10889209 | ||
| 119 | N-linked_Glycosylation | LNKAHVGNYTPCVAN CCCCCCCCCCCCEEE | 10889209 | ||
| 369 | Phosphorylation | EEMLLMSSPLIAPAI HHHHHHCCCCCHHHH | - | ||
| 385 | Phosphorylation | NSKERHNSVECLDGL CCHHHCCCCHHHCCH | 25849741 | ||
| 401 | Phosphorylation | DITTKLPSKLQKITG HHHHHCCHHHHHHHC | 24719451 | ||
| 407 | Phosphorylation | PSKLQKITGREDFPK CHHHHHHHCCCCCCH | - | ||
| 420 | Phosphorylation | PKKLLRMSSTTSEKA CHHHHHCCCCCCCCC | - | ||
| 424 | Phosphorylation | LRMSSTTSEKAYSLG HHCCCCCCCCCHHCC | - | ||
| 441 | Phosphorylation | PMKLQRISSVPGNSE CCEEEEECCCCCCCH | 28348404 | ||
| 442 | Phosphorylation | MKLQRISSVPGNSEE CEEEEECCCCCCCHH | 22985185 | ||
| 457 | Acetylation | KLVSKTTKMLSDPMS HHHHHHHHHHCCCCC | 19813233 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 385 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 385 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNJ3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNJ3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GBB1_HUMAN | GNB1 | physical | 12743112 | |
| KCNJ5_HUMAN | KCNJ5 | physical | 9108307 | |
| ADRB2_HUMAN | ADRB2 | physical | 12297500 | |
| KCNJ5_HUMAN | KCNJ5 | genetic | 11741896 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| D00631 | Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN); Vascor (TN) |
| D00636 | Amiodarone hydrochloride (JP16/USAN); Ancaron (TN); Cordarone (TN) |
| D02537 | Dronedarone (INN) |
| D02910 | Amiodarone (USAN/INN) |
| D03914 | Dronedarone hydrochloride (USAN); Multaq (TN) |
| D07520 | Bepridil (INN); Bepadin (TN) |
| DrugBank | |
| DB00898 | Ethanol |
| DB01159 | Halothane |
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