KCNJ5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNJ5_HUMAN
• UniProt AC: P48544
• Protein Name: G protein-activated inward rectifier potassium channel 4
• Gene Name: KCNJ5
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium..
• Protein Sequence: MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAGDSRNAMNQD ---CCCCCCCCCCCC		-
75	Phosphorylation	QETYRYLSDLFTTLV HHHHHHHHHHHHHHH		-
79	Phosphorylation	RYLSDLFTTLVDLKW HHHHHHHHHHHHHHH		17924679
199	Phosphorylation	QPKKRAETLMFSNNA CCCCHHHEEEECCCE		28122231
203	Phosphorylation	RAETLMFSNNAVISM HHHEEEECCCEEEEE		28122231
412	Phosphorylation	EPKGLGGSREARGSV CCCCCCCCCCCCCCC		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
199	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
412	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNJ5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNJ5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADRB2_HUMAN	ADRB2	physical	12297500
KCNJ3_HUMAN	KCNJ3	physical	28514442
ERI3_HUMAN	ERI3	physical	28514442
WIPI3_HUMAN	WDR45B	physical	28514442
LANC2_HUMAN	LANCL2	physical	28514442
MTMR6_HUMAN	MTMR6	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
PLCG1_HUMAN	PLCG1	physical	28514442
ATG7_HUMAN	ATG7	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442
PKP4_HUMAN	PKP4	physical	28514442
NUP53_HUMAN	NUP35	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.