ERI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERI3_HUMAN
• UniProt AC: O43414
• Protein Name: ERI1 exoribonuclease 3
• Gene Name: ERI3
• Organism: Homo sapiens (Human).
• Sequence Length: 337
• Protein Sequence: MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTEPSASPAAGLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLFSPCGVPEFCSISTRKLAAHGFGASMAAMVSFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQTSKPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	SPAADGGRGRPWEGG CCCCCCCCCCCCCCC	43.40	-
21 (in isoform 3)	Ubiquitination	-	6.77	21890473
104	Phosphorylation	RARKVLGSHLFSPCG HHHHHHHHHCCCCCC	16.92	-
112 (in isoform 3)	Ubiquitination	-	5.38	21890473
115 (in isoform 2)	Ubiquitination	-	3.03	21890473
122 (in isoform 3)	Ubiquitination	-	42.43	21890473
206 (in isoform 2)	Ubiquitination	-	1.45	21890473
216 (in isoform 2)	Ubiquitination	-	30.81	21890473
230	Ubiquitination	RVDEWMAKEGLLDPN HHHHHHHHCCCCCCC	35.89	21906983
230 (in isoform 1)	Ubiquitination	-	35.89	21890473
239	Acetylation	GLLDPNVKSIFVTCG CCCCCCCCEEEEEEC	44.46	25038526
276	Ubiquitination	FKQWINLKKAYSFAM HHHHHCHHHHHHHHC	30.76	-
276	Acetylation	FKQWINLKKAYSFAM HHHHHCHHHHHHHHC	30.76	25953088
277	Malonylation	KQWINLKKAYSFAMG HHHHCHHHHHHHHCC	56.58	26320211
296	Ubiquitination	NGLLDMNKGLSLQHI CCCCCCCCCCCHHHC	55.37	-
299	Phosphorylation	LDMNKGLSLQHIGRP CCCCCCCCHHHCCCC	34.35	28348404
314	Acetylation	HSGIDDCKNIANIMK CCCHHHHHHHHHHHH	59.38	25038526
314	Ubiquitination	HSGIDDCKNIANIMK CCCHHHHHHHHHHHH	59.38	-
321	Acetylation	KNIANIMKTLAYRGF HHHHHHHHHHHHCCC	36.27	26051181
321 (in isoform 1)	Ubiquitination	-	36.27	21890473
321	Ubiquitination	KNIANIMKTLAYRGF HHHHHHHHHHHHCCC	36.27	21890473
322	Phosphorylation	NIANIMKTLAYRGFI HHHHHHHHHHHCCCE	10.15	23882029
331	Acetylation	AYRGFIFKQTSKPF- HHCCCEEEECCCCC-	48.10	25953088
331 (in isoform 1)	Ubiquitination	-	48.10	21890473
331	Ubiquitination	AYRGFIFKQTSKPF- HHCCCEEEECCCCC-	48.10	21890473
331	Malonylation	AYRGFIFKQTSKPF- HHCCCEEEECCCCC-	48.10	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERI3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTK_HUMAN	TTK	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.