MSRA_HUMAN - dbPTM
MSRA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSRA_HUMAN
UniProt AC Q9UJ68
Protein Name Mitochondrial peptide methionine sulfoxide reductase
Gene Name MSRA
Organism Homo sapiens (Human).
Sequence Length 235
Subcellular Localization Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm. Membrane
Lipid-anchor .
Protein Description Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine..
Protein Sequence MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 5)Myristoylation-4.8525807930
40UbiquitinationPQEALPGRKEQTPVA
HHHHCCCCCCCCCCC		37.0829967540
41MethylationQEALPGRKEQTPVAA
HHHCCCCCCCCCCCE		61.15-
46UbiquitinationGRKEQTPVAAKHHVN
CCCCCCCCCEECCCC		10.3229967540
49MethylationEQTPVAAKHHVNGNR
CCCCCCEECCCCCCC		25.22-
63UbiquitinationRTVEPFPEGTQMAVF
CCCCCCCCCCEEEEE		75.2229967540
69UbiquitinationPEGTQMAVFGMGCFW
CCCCEEEEEEECCCC		3.4129967540
75UbiquitinationAVFGMGCFWGAERKF
EEEEECCCCCHHHHH		5.8122817900
80UbiquitinationGCFWGAERKFWVLKG
CCCCCHHHHHHEEEE		38.6521890473
101UbiquitinationGFAGGYTSNPTYKEV
EECCCCCCCCCHHHH		32.1229967540
106SuccinylationYTSNPTYKEVCSEKT
CCCCCCHHHHHCCCC		46.26-
106AcetylationYTSNPTYKEVCSEKT
CCCCCCHHHHHCCCC		46.2625038526
106UbiquitinationYTSNPTYKEVCSEKT
CCCCCCHHHHHCCCC		46.2629967540
106SuccinylationYTSNPTYKEVCSEKT
CCCCCCHHHHHCCCC		46.26-
110UbiquitinationPTYKEVCSEKTGHAE
CCHHHHHCCCCCCEE		47.5022817900
112UbiquitinationYKEVCSEKTGHAEVV
HHHHHCCCCCCEEEE		43.4429967540
115UbiquitinationVCSEKTGHAEVVRVV
HHCCCCCCEEEEEEE		24.7721890473
124UbiquitinationEVVRVVYQPEHMSFE
EEEEEEECCCCCCHH		25.8729967540
127UbiquitinationRVVYQPEHMSFEELL
EEEECCCCCCHHHHH		24.7029967540
133UbiquitinationEHMSFEELLKVFWEN
CCCCHHHHHHHHHHC		4.4022817900
135AcetylationMSFEELLKVFWENHD
CCHHHHHHHHHHCCC		48.2725038526
136UbiquitinationSFEELLKVFWENHDP
CHHHHHHHHHHCCCC		7.3222817900
138UbiquitinationEELLKVFWENHDPTQ
HHHHHHHHHCCCCCC		14.4121890473
138UbiquitinationEELLKVFWENHDPTQ
HHHHHHHHHCCCCCC		14.4121890473
138UbiquitinationEELLKVFWENHDPTQ
HHHHHHHHHCCCCCC		14.4121890473
141UbiquitinationLKVFWENHDPTQGMR
HHHHHHCCCCCCCCC		30.8021890473
146UbiquitinationENHDPTQGMRQGNDH
HCCCCCCCCCCCCCC		18.7321890473
157PhosphorylationGNDHGTQYRSAIYPT
CCCCCHHHCCCCCCC		13.3322210691
167UbiquitinationAIYPTSAKQMEAALS
CCCCCCHHHHHHHHH		50.3629967540
174PhosphorylationKQMEAALSSKENYQK
HHHHHHHHCHHHHHH		34.3426853621
175PhosphorylationQMEAALSSKENYQKV
HHHHHHHCHHHHHHH		44.8526853621
176UbiquitinationMEAALSSKENYQKVL
HHHHHHCHHHHHHHH		46.7522817900
181UbiquitinationSSKENYQKVLSEHGF
HCHHHHHHHHHHHCC		34.4822817900
181UbiquitinationSSKENYQKVLSEHGF
HCHHHHHHHHHHHCC		34.4821890473
184PhosphorylationENYQKVLSEHGFGPI
HHHHHHHHHHCCCCE		30.4525693802
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSRA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSRA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSRA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CH10_HUMANHSPE1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00134L-Methionine
Regulatory Network of MSRA_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory