COL12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COL12_HUMAN
• UniProt AC: Q5KU26
• Protein Name: Collectin-12
• Gene Name: COLEC12
• Organism: Homo sapiens (Human).
• Sequence Length: 742
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . Forms clusters on the cell surface.
• Protein Description: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease..
• Protein Sequence: MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKDRETVLSSAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	EEVQSFGYKRFGIQE HHHHHCCCCCCCCCC	9.29	-
17	Ubiquitination	EVQSFGYKRFGIQEG HHHHCCCCCCCCCCC	41.45	32015554
67	N-linked_Glycosylation	KVVEKMDNVTGGMET HHHHCCCCCCCCCCC	29.74	UniProtKB CARBOHYD
69	Phosphorylation	VEKMDNVTGGMETSR HHCCCCCCCCCCCCC	33.98	-
74	Phosphorylation	NVTGGMETSRQTYDD CCCCCCCCCCCHHHH	21.95	-
78	Phosphorylation	GMETSRQTYDDKLTA CCCCCCCHHHHHHHH	28.01	-
104	Phosphorylation	TGKKAISTNSELSTF CCCCCCCCCHHHHHH	36.33	-
106	Phosphorylation	KKAISTNSELSTFRS CCCCCCCHHHHHHHH	39.75	-
109	Phosphorylation	ISTNSELSTFRSDIL CCCCHHHHHHHHHHH	22.81	-
110	Phosphorylation	STNSELSTFRSDILD CCCHHHHHHHHHHHH	35.37	-
128	Acetylation	QLREITEKTSKNKDT HHHHHHHHHCCCHHH	49.82	24848101
131	Acetylation	EITEKTSKNKDTLEK HHHHHHCCCHHHHHH	73.56	24848109
149	Methylation	SGDALVDRQSQLKET HCHHHHHCHHHHHHH	30.48	-
159	N-linked_Glycosylation	QLKETLENNSFLITT HHHHHHHCCCEEEEE	53.19	UniProtKB CARBOHYD
168	N-linked_Glycosylation	SFLITTVNKTLQAYN CEEEEEHHHHHHHHC	29.51	UniProtKB CARBOHYD
252	Ubiquitination	QQVFLQAKKDTDWLK HHHHHHHHCCCHHHH	37.92	32015554
271	N-linked_Glycosylation	SLQTLAANNSALAKA HHHHHHHCHHHHHHH	37.06	UniProtKB CARBOHYD
396	Phosphorylation	LANIRLDSVSLRMQQ HHHHHHHHHHHHHHH	20.42	24719451
398	Phosphorylation	NIRLDSVSLRMQQDL HHHHHHHHHHHHHHH	17.76	24719451
408	Phosphorylation	MQQDLMRSRLDTEVA HHHHHHHHCCCHHHH	24.19	22210691
425	Acetylation	SVIMEEMKLVDSKHG HHHHHHHHHHHCCCC	48.95	7711411
439	Phosphorylation	GQLIKNFTILQGPPG CCEEECEEEEECCCC	30.12	22210691
687	Phosphorylation	LDGTSPDYKNWKAGQ CCCCCCCCCCCCCCC	15.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COL12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COL12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COL12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ZC4H2_HUMAN	ZC4H2	physical	28514442
TMX1_HUMAN	TMX1	physical	28514442
DPH2_HUMAN	DPH2	physical	28514442
CSPG5_HUMAN	CSPG5	physical	28514442
LAMB1_HUMAN	LAMB1	physical	28514442
A16L1_HUMAN	ATG16L1	physical	28514442
HOME1_HUMAN	HOMER1	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.