ZC4H2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZC4H2_HUMAN
• UniProt AC: Q9NQZ6
• Protein Name: Zinc finger C4H2 domain-containing protein
• Gene Name: ZC4H2
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Cytoplasm . Nucleus . Cell junction, synapse, postsynaptic cell membrane . Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites.
• Protein Description: Plays a role in interneurons differentiation. [PubMed: 26056227 Involved in neuronal development and in neuromuscular junction formation.]
• Protein Sequence: MADEQEIMCKLESIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLESTRRLHDEYKPLKEHVDALRMTLGLQRLPDLCEEEEKLSLDYFEKQKAEWQTEPQEPPIPESLAAAAAAAQQLQVARKQDTRQTATFRQQPPPMKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRKQDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	MCKLESIKEIRNKTL HHHHHHHHHHHHHCC	57.26	7431253
15	Ubiquitination	MCKLESIKEIRNKTL HHHHHHHHHHHHHCC	57.26	29967540
20	Trimethylation	SIKEIRNKTLQMEKI HHHHHHHHCCCHHHH	40.54	-
20	Methylation	SIKEIRNKTLQMEKI HHHHHHHHCCCHHHH	40.54	23644510
26	Acetylation	NKTLQMEKIKARLKA HHCCCHHHHHHHHHH	44.13	7431263
28	Trimethylation	TLQMEKIKARLKAEF CCCHHHHHHHHHHHH	38.22	-
28	Methylation	TLQMEKIKARLKAEF CCCHHHHHHHHHHHH	38.22	23644510
32	Acetylation	EKIKARLKAEFEALE HHHHHHHHHHHHHHH	40.07	7431273
36	Ubiquitination	ARLKAEFEALESEER HHHHHHHHHHHHHHH	43.80	29967540
58	Ubiquitination	EMDLLLQEKMAHVEE HHHHHHHHHHHCHHH	44.78	29967540
59	Ubiquitination	MDLLLQEKMAHVEEL HHHHHHHHHHCHHHH	28.55	29967540
66	Ubiquitination	KMAHVEELRLIHADI HHHCHHHHHHHHHHH	3.23	29967540
79	Ubiquitination	DINVMENTIKQSEND HHHHHHHHHHHCHHH	19.08	29967540
81	Ubiquitination	NVMENTIKQSENDLN HHHHHHHHHCHHHHH	45.81	29967540
82	Ubiquitination	VMENTIKQSENDLNK HHHHHHHHCHHHHHH	52.72	29967540
89	Ubiquitination	QSENDLNKLLESTRR HCHHHHHHHHHHHHH	62.84	29967540
102	Ubiquitination	RRLHDEYKPLKEHVD HHHHHHHHHHHHHHH	41.65	29967540
105	Ubiquitination	HDEYKPLKEHVDALR HHHHHHHHHHHHHHH	55.06	29967540
114	Ubiquitination	HVDALRMTLGLQRLP HHHHHHHHHHHHHCH	15.96	29967540
131	Phosphorylation	CEEEEKLSLDYFEKQ HHHHHHCCHHHHHHH	30.20	-
134	Phosphorylation	EEKLSLDYFEKQKAE HHHCCHHHHHHHHCC	20.94	-
137	Ubiquitination	LSLDYFEKQKAEWQT CCHHHHHHHHCCCCC	47.39	29967540
173	Phosphorylation	QVARKQDTRQTATFR HHHHHCCCHHCCHHH	23.37	-
210	Phosphorylation	CPLCKAKSRSRNPKK HHHHHHHCCCCCCCC	40.11	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZC4H2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZC4H2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZC4H2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KXDL1_HUMAN	KXD1	physical	16189514
ZN490_HUMAN	ZNF490	physical	25416956
ZN250_HUMAN	ZNF250	physical	25416956
ZN524_HUMAN	ZNF524	physical	25416956
AGGF1_HUMAN	AGGF1	physical	26186194
HOOK3_HUMAN	HOOK3	physical	26186194
RN220_HUMAN	RNF220	physical	26186194
ZN250_HUMAN	ZNF250	physical	21516116
AGGF1_HUMAN	AGGF1	physical	28514442
RN220_HUMAN	RNF220	physical	28514442
HOOK3_HUMAN	HOOK3	physical	28514442
GT2D1_HUMAN	GTF2IRD1	physical	26275350

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.