| UniProt ID | CLIC6_HUMAN | |
|---|---|---|
| UniProt AC | Q96NY7 | |
| Protein Name | Chloride intracellular channel protein 6 | |
| Gene Name | CLIC6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 704 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Single-pass membrane protein. Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity).. |
|
| Protein Description | May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).. | |
| Protein Sequence | MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | EAEGPEGSEGAEEAP CCCCCCCCCCHHHCC | 31.06 | 28348404 | |
| 112 | Phosphorylation | AQQVEGASPGRGAQG CEECCCCCCCCCCCC | 38.45 | 26657352 | |
| 189 | Phosphorylation | AEGRVGDSVDAEGPA ECCCCCCCCCCCCCC | 18.90 | - | |
| 219 | Phosphorylation | AEGPAGDSVDAEGRV EECCCCCCCCCCCCC | 22.45 | - | |
| 229 | Phosphorylation | AEGRVGDSVDAEGPA CCCCCCCCCCCCCCC | 18.90 | 28348404 | |
| 239 | Phosphorylation | AEGPAGDSVDAEGRV CCCCCCCCCCCCCCC | 22.45 | 27251275 | |
| 293 | Phosphorylation | AGRARRVSGEPQQSG CCCCCCCCCCCCCCC | 35.31 | 29255136 | |
| 299 | Phosphorylation | VSGEPQQSGDGSLSP CCCCCCCCCCCCCCH | 33.34 | 26657352 | |
| 303 | Phosphorylation | PQQSGDGSLSPQAEA CCCCCCCCCCHHHHH | 30.34 | 30278072 | |
| 305 | Phosphorylation | QSGDGSLSPQAEAIE CCCCCCCCHHHHHHH | 19.36 | 26657352 | |
| 318 | Phosphorylation | IEVAAGESAGRSPGE HHHHCCCCCCCCCCC | 34.80 | 27251275 | |
| 322 | Phosphorylation | AGESAGRSPGELAWD CCCCCCCCCCCCCCH | 36.02 | 26657352 | |
| 377 | Phosphorylation | DEERRERSPEGPREE CHHHHHHCCCCCHHH | 23.66 | 26657352 | |
| 393 | Phosphorylation | AAGGEEESPDSSPHG HCCCCCCCCCCCCCC | 36.97 | 26657352 | |
| 396 | Phosphorylation | GEEESPDSSPHGEAS CCCCCCCCCCCCCHH | 49.51 | 30108239 | |
| 397 | Phosphorylation | EEESPDSSPHGEASR CCCCCCCCCCCCHHC | 28.44 | 28192239 | |
| 403 | Phosphorylation | SSPHGEASRGAAEPE CCCCCCHHCCCCCHH | 27.26 | 30108239 | |
| 414 | Phosphorylation | AEPEAQLSNHLAEEG CCHHHHHHHHHHHHC | 15.32 | 27251275 | |
| 426 | Phosphorylation | EEGPAEGSGEAARVN HHCCCCCCCCCCEEC | 25.60 | 27251275 | |
| 442 | Phosphorylation | RREDGEASEPRALGQ CCCCCCCCCCCCCCC | 43.78 | - | |
| 479 | Phosphorylation | KKYLRAGYDGESIGN HHHHHCCCCCCCCCC | 21.57 | 22817900 | |
| 494 | Ubiquitination | CPFSQRLFMILWLKG CCHHHHHHHHHHHHC | 2.89 | 23000965 | |
| 496 | Ubiquitination | FSQRLFMILWLKGVI HHHHHHHHHHHHCCC | 1.63 | 23000965 | |
| 512 | Ubiquitination | NVTTVDLKRKPADLQ EEEEECCCCCCCHHH | 54.64 | 23000965 | |
| 514 | Ubiquitination | TTVDLKRKPADLQNL EEECCCCCCCHHHHC | 42.86 | 23000965 | |
| 624 | Phosphorylation | AYSTEDVTVSGRKFL CCCCCCEEECCCEEC | 22.67 | - | |
| 626 | Phosphorylation | STEDVTVSGRKFLDG CCCCEEECCCEECCC | 24.42 | - | |
| 629 | Ubiquitination | DVTVSGRKFLDGDEL CEEECCCEECCCCCC | 54.53 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLIC6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLIC6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLIC6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CLIC6_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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