VA0D1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VA0D1_HUMAN
• UniProt AC: P61421
• Protein Name: V-type proton ATPase subunit d 1
• Gene Name: ATP6V0D1
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to centrosome and the base of the cilium.
• Protein Description: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. [PubMed: 28296633]
• Protein Sequence: MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	EGLVRGLKAGVLSQA HHHHHHHHHCCCCHH	46.01	-
46	Ubiquitination	CETLEDLKLHLQSTD CCCHHHHHHHHHCCC	46.30	-
77	2-Hydroxyisobutyrylation	IDDRLKEKMVVEFRH ECHHHHHHHHEEEHH	35.09	-
77	Ubiquitination	IDDRLKEKMVVEFRH ECHHHHHHHHEEEHH	35.09	-
187	Acetylation	IIRNTLYKAYLESFY HHHHHHHHHHHHHHH	33.40	26051181
224	Phosphorylation	DRRAFIITINSFGTE CCCEEEEEECCCCCC	14.86	-
227	Phosphorylation	AFIITINSFGTELSK EEEEEECCCCCCCCH	22.62	-
230	Phosphorylation	ITINSFGTELSKEDR EEECCCCCCCCHHHH	31.57	-
233	Phosphorylation	NSFGTELSKEDRAKL CCCCCCCCHHHHHHH	27.97	-
234	Ubiquitination	SFGTELSKEDRAKLF CCCCCCCHHHHHHHC	76.02	-
239	Ubiquitination	LSKEDRAKLFPHCGR CCHHHHHHHCCCCCC	52.10	-
248	Phosphorylation	FPHCGRLYPEGLAQL CCCCCCCCHHHHHHH	9.62	24927040
265	Ubiquitination	ADDYEQVKNVADYYP CCCHHHHHCHHHHCH	45.45	21890473
270	Phosphorylation	QVKNVADYYPEYKLL HHHCHHHHCHHHHHH	15.93	19060867
271	Phosphorylation	VKNVADYYPEYKLLF HHCHHHHCHHHHHHH	7.08	22210691
274	Phosphorylation	VADYYPEYKLLFEGA HHHHCHHHHHHHCCC	11.48	-
275	Ubiquitination	ADYYPEYKLLFEGAG HHHCHHHHHHHCCCC	36.73	21890473
283	Phosphorylation	LLFEGAGSNPGDKTL HHHCCCCCCCCCCCH	39.04	25850435
288	Ubiquitination	AGSNPGDKTLEDRFF CCCCCCCCCHHHHHH	62.01	21890473
289	Phosphorylation	GSNPGDKTLEDRFFE CCCCCCCCHHHHHHH	39.87	22210691
293	Methylation	GDKTLEDRFFEHEVK CCCCHHHHHHHHHHH	28.86	-
300	Ubiquitination	RFFEHEVKLNKLAFL HHHHHHHHHHHHHHH	43.27	-
343	Ubiquitination	IAQRHRAKIDNYIPI HHHHHHHHHCCCCCC	51.02	2190698
347	Phosphorylation	HRAKIDNYIPIF--- HHHHHCCCCCCC---	12.34	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VA0D1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VA0D1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VA0D1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT1A1_HUMAN	ATP1A1	physical	26344197
ATPA_HUMAN	ATP5A1	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
ATPO_HUMAN	ATP5O	physical	26344197
VPP1_HUMAN	ATP6V0A1	physical	26344197
EIF3A_HUMAN	EIF3A	physical	26344197
NDUB8_HUMAN	NDUFB8	physical	26344197
NDUS4_HUMAN	NDUFS4	physical	26344197
NDUV1_HUMAN	NDUFV1	physical	26344197
PSMD3_HUMAN	PSMD3	physical	26344197
RAB2A_HUMAN	RAB2A	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
SSRA_HUMAN	SSR1	physical	26344197
QCR6_HUMAN	UQCRH	physical	26344197
MVD1_HUMAN	MVD	physical	28514442
VPP2_HUMAN	ATP6V0A2	physical	28514442
VA0D2_HUMAN	ATP6V0D2	physical	28514442
LEPR_HUMAN	LEPR	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
SNX25_HUMAN	SNX25	physical	28514442
VMA21_HUMAN	VMA21	physical	28514442
S22AN_HUMAN	SLC22A23	physical	28514442
VPP3_HUMAN	TCIRG1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
S27A6_HUMAN	SLC27A6	physical	28514442
CC115_HUMAN	CCDC115	physical	28514442
UBP4_HUMAN	USP4	physical	28514442
SNX19_HUMAN	SNX19	physical	28514442
F210B_HUMAN	FAM210B	physical	28514442
M1IP1_HUMAN	MID1IP1	physical	28514442
DHC24_HUMAN	DHCR24	physical	28514442
PGES2_HUMAN	PTGES2	physical	28514442
RENR_HUMAN	ATP6AP2	physical	28514442
SHIP2_HUMAN	INPPL1	physical	28514442
B3GN2_HUMAN	B3GNT2	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442
VAS1_HUMAN	ATP6AP1	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
CUL4A_HUMAN	CUL4A	physical	28514442
MFS4B_HUMAN	KIAA1919	physical	28514442
VATF_HUMAN	ATP6V1F	physical	28514442
K2013_HUMAN	KIAA2013	physical	28514442
LETM1_HUMAN	LETM1	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
SCPDL_HUMAN	SCCPDH	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
ENPP1_HUMAN	ENPP1	physical	28514442
ACSL4_HUMAN	ACSL4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.