RDH13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RDH13_HUMAN
• UniProt AC: Q8NBN7
• Protein Name: Retinol dehydrogenase 13
• Gene Name: RDH13
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Protein Description: Does not exhibit retinol dehydrogenase (RDH) activity in vitro..
• Protein Sequence: MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSRYLLPLS ------CCCCCCCHH	29.63	25944712
4	Phosphorylation	----MSRYLLPLSAL ----CCCCCCCHHHH	12.80	-
9	Phosphorylation	SRYLLPLSALGTVAG CCCCCCHHHHHHHHH	21.36	-
31 (in isoform 2)	Ubiquitination	-	38.03	-
33	Ubiquitination	TGGACPSKATIPGKT CCCCCCCCCCCCCCE	34.39	21890473
35	Phosphorylation	GACPSKATIPGKTVI CCCCCCCCCCCCEEE	31.29	-
40	Phosphorylation	KATIPGKTVIVTGAN CCCCCCCEEEEECCC	22.75	21406692
44	Phosphorylation	PGKTVIVTGANTGIG CCCEEEEECCCCCCC	21.32	21406692
48	Phosphorylation	VIVTGANTGIGKQTA EEEECCCCCCCHHHH	29.64	21406692
100	Phosphorylation	ARHLDLASLKSIREF HHHCCHHHHHHHHHH	43.56	20873877
102	Ubiquitination	HLDLASLKSIREFAA HCCHHHHHHHHHHHH	41.14	21890473
103	Phosphorylation	LDLASLKSIREFAAK CCHHHHHHHHHHHHH	31.97	20873877
194	Phosphorylation	LNWQTRKYNTKAAYC CCCCCCCCCCHHHHH	25.44	25332170
197	Ubiquitination	QTRKYNTKAAYCQSK CCCCCCCHHHHHHHH	27.64	-
200	Phosphorylation	KYNTKAAYCQSKLAI CCCCHHHHHHHHHHH	8.90	-
212	Ubiquitination	LAIVLFTKELSRRLQ HHHHHHHHHHHHHHC	49.69	21890473
221 (in isoform 2)	Ubiquitination	-	19.68	-
223 (in isoform 2)	Ubiquitination	-	6.06	-
263	Phosphorylation	IFWLLVKSPELAAQP EEEEEECCHHHHCCC	19.00	27174698
271	Phosphorylation	PELAAQPSTYLAVAE HHHHCCCCHHHHHHH	20.01	27174698
272	Phosphorylation	ELAAQPSTYLAVAEE HHHCCCCHHHHHHHH	29.27	27174698
273	Phosphorylation	LAAQPSTYLAVAEEL HHCCCCHHHHHHHHH	9.30	27174698
284	Phosphorylation	AEELADVSGKYFDGL HHHHHHHCCCCCCCC	30.07	27174698
292	Ubiquitination	GKYFDGLKQKAPAPE CCCCCCCCCCCCCCC	56.11	-
294	Ubiquitination	YFDGLKQKAPAPEAE CCCCCCCCCCCCCCC	55.54	21890473
323	Phosphorylation	LVGLEAPSVREQPLP HHCCCCCCCCCCCCC	40.63	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RDH13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RDH13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RDH13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OST48_HUMAN	DDOST	physical	26344197
KDSR_HUMAN	KDSR	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
RPN2_HUMAN	RPN2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00162: Vitamin A