| UniProt ID | RENR_HUMAN | |
|---|---|---|
| UniProt AC | O75787 | |
| Protein Name | Renin receptor | |
| Gene Name | ATP6AP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 350 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).. | |
| Protein Sequence | MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | GVLGNEFSILKSPGS HHHCCCCHHCCCCCE | 22.34 | 24719451 | |
| 24 | Phosphorylation | NEFSILKSPGSVVFR CCCHHCCCCCEEEEE | 30.92 | 25159151 | |
| 27 | Phosphorylation | SILKSPGSVVFRNGN HHCCCCCEEEEECCC | 20.63 | 23186163 | |
| 49 | Phosphorylation | IPDVAALSMGFSVKE CCCCHHHHCCCCCCC | 16.48 | 22210691 | |
| 53 | Phosphorylation | AALSMGFSVKEDLSW HHHHCCCCCCCCCCC | 26.92 | 22210691 | |
| 81 | Ubiquitination | ATVMVMVKGVNKLAL CEEEEEECCCCCCCC | 38.76 | 29967540 | |
| 107 | Ubiquitination | NAVPFSLDSVANSIH CCCCCCHHHHHHHHH | 39.61 | 21890473 | |
| 139 | Ubiquitination | ERVYMVGKANSVFED CEEEEEECHHHHHHH | 32.74 | 21906983 | |
| 150 | Phosphorylation | VFEDLSVTLRQLRNR HHHHHHHHHHHHHHH | 16.91 | 24719451 | |
| 192 | Ubiquitination | SELQVLHDISSLLSR HHHHHHHHHHHHHHH | 38.00 | 21890473 | |
| 195 | Phosphorylation | QVLHDISSLLSRHKH HHHHHHHHHHHHCHH | 33.39 | 24719451 | |
| 198 | Phosphorylation | HDISSLLSRHKHLAK HHHHHHHHHCHHHHC | 37.32 | 24719451 | |
| 201 | Ubiquitination | SSLLSRHKHLAKDHS HHHHHHCHHHHCCCC | 38.92 | 23503661 | |
| 205 | Ubiquitination | SRHKHLAKDHSPDLY HHCHHHHCCCCCCCH | 63.43 | 23503661 | |
| 206 | Ubiquitination | RHKHLAKDHSPDLYS HCHHHHCCCCCCCHH | 41.72 | 21890473 | |
| 224 | Ubiquitination | AGLDEIGKRYGEDSE CCHHHHHHHHCCCHH | 48.37 | 21906983 | |
| 238 | Ubiquitination | EQFRDASKILVDALQ HHHHHHHHHHHHHHH | 41.60 | 23000965 | |
| 252 | Ubiquitination | QKFADDMYSLYGGNA HHHHHHHHHHHCCCE | 11.52 | 21890473 | |
| 272 | Phosphorylation | TVKSFDTSLIRKTRT EEEECCHHHHHHHHH | 24.52 | 24719451 | |
| 275 | Methylation | SFDTSLIRKTRTILE ECCHHHHHHHHHHHH | 39.32 | - | |
| 284 | Ubiquitination | TRTILEAKQAKNPAS HHHHHHHHHCCCCCC | 41.22 | 22817900 | |
| 287 | Methylation | ILEAKQAKNPASPYN HHHHHHCCCCCCCCC | 62.05 | - | |
| 287 | Ubiquitination | ILEAKQAKNPASPYN HHHHHHCCCCCCCCC | 62.05 | 22817900 | |
| 287 | Trimethylation | ILEAKQAKNPASPYN HHHHHHCCCCCCCCC | 62.05 | - | |
| 291 | Phosphorylation | KQAKNPASPYNLAYK HHCCCCCCCCCEEHH | 29.22 | 25159151 | |
| 293 | Phosphorylation | AKNPASPYNLAYKYN CCCCCCCCCEEHHCC | 21.95 | 21406692 | |
| 297 | Phosphorylation | ASPYNLAYKYNFEYS CCCCCEEHHCCCCHH | 19.71 | 21406692 | |
| 314 | Ubiquitination | FNMVLWIMIALALAV HHHHHHHHHHHHHHH | 0.71 | 21890473 | |
| 346 | Ubiquitination | IYRMTNQKIRMD--- HHHHCCCCCCCC--- | 34.06 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RENR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RENR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RENR_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00577 | Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part | |||||
| OMIM Disease | ||||||
| 300423 | Mental retardation, X-linked, with epilepsy (MRXE) | |||||
| 300911 | Parkinsonism with spasticity, X-linked (XPDS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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