| UniProt ID | RENI_HUMAN | |
|---|---|---|
| UniProt AC | P00797 | |
| Protein Name | Renin | |
| Gene Name | REN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 406 | |
| Subcellular Localization | Secreted. Membrane. Associated to membranes via binding to ATP6AP2. | |
| Protein Description | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.. | |
| Protein Sequence | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | IFLKRMPSIRESLKE HHHHHCHHHHHHHHH | 25.57 | 28674151 | |
| 45 | Phosphorylation | RMPSIRESLKERGVD HCHHHHHHHHHCCCC | 34.59 | - | |
| 71 | N-linked_Glycosylation | MKRLTLGNTTSSVIL CCEEECCCCCCEEEE | 43.21 | UniProtKB CARBOHYD | |
| 71 | N-linked_Glycosylation | MKRLTLGNTTSSVIL CCEEECCCCCCEEEE | 43.21 | 3066525 | |
| 87 | Phosphorylation | NYMDTQYYGEIGIGT CCCCCCEEEECCCCC | 9.85 | - | |
| 141 | N-linked_Glycosylation | DSSSYKHNGTELTLR CCCCCCCCCEEEEEE | 55.73 | UniProtKB CARBOHYD | |
| 141 | N-linked_Glycosylation | DSSSYKHNGTELTLR CCCCCCCCCEEEEEE | 55.73 | 3066525 | |
| 330 | Phosphorylation | VKCNEGPTLPDISFH EECCCCCCCCCEEEE | 62.88 | - | |
| 347 | Phosphorylation | GKEYTLTSADYVFQE CEEEEECCCCEEEEC | 23.43 | - | |
| 355 | Phosphorylation | ADYVFQESYSSKKLC CCEEEECCCCCCCCE | 21.38 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RENI_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RENI_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RENI_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RENR_HUMAN | ATP6AP2 | physical | 12045255 | |
| ANGT_HUMAN | AGT | physical | 12045255 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00541 | Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juveni | |||||
| H00575 | Renal tubular dysgenesis | |||||
| OMIM Disease | ||||||
| 267430 | Renal tubular dysgenesis (RTD) | |||||
| 613092 | Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) | |||||
| Kegg Drug | ||||||
| D03208 | Aliskiren (USAN/INN); Rasilez (TN) | |||||
| D03738 | Enalkiren (USAN/INN) | |||||
| D03741 | Ditekiren (USAN) | |||||
| D03743 | Terlakiren (USAN/INN) | |||||
| D03745 | Zankiren hydrochloride (USAN) | |||||
| D06412 | Aliskiren fumarate (JAN/USAN); Aliskiren hemifumarate; Tekturna (TN) | |||||
| D09038 | Remikiren (INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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