dbPTM

ANGT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANGT_HUMAN
UniProt AC	P01019
Protein Name	Angiotensinogen
Gene Name	AGT
Organism	Homo sapiens (Human).
Sequence Length	485
Subcellular Localization	Secreted.
Protein Description	Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; Angiotensin-3: stimulates aldosterone release.; Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets..
Protein Sequence	MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	O-linked_Glycosylation	MRKRAPQSEMAPAGV CCCCCCHHHCCCCCH	28.42	30620550
8	Phosphorylation	MRKRAPQSEMAPAGV CCCCCCHHHCCCCCH	28.42	26074081
16	O-linked_Glycosylation	EMAPAGVSLRATILC HCCCCCHHHHHHHHH	15.95	30620550
16	Phosphorylation	EMAPAGVSLRATILC HCCCCCHHHHHHHHH	15.95	26074081
20	Phosphorylation	AGVSLRATILCLLAW CCHHHHHHHHHHHHH	14.19	26074081
34	Beta-decarboxylated aspartate	WAGLAAGDRVYIHPF HHHHHCCCCEEEECC	31.95	-
34	Decarboxylation	WAGLAAGDRVYIHPF HHHHHCCCCEEEECC	31.95	17138938
47	N-linked_Glycosylation	PFHLVIHNESTCEQL CCEEEEECHHHHHHH	33.52	3934016
47	N-linked_Glycosylation	PFHLVIHNESTCEQL CCEEEEECHHHHHHH	33.52	3934016
100	Ubiquitination	AKLDTEDKLRAAMVG EECCHHHHHHHHHHH	33.37	-
170	N-linked_Glycosylation	GVPWKDKNCTSRLDA CCCCCCCCCCCCCCH	44.42	9757569
170	N-linked_Glycosylation	GVPWKDKNCTSRLDA CCCCCCCCCCCCCCH	44.42	3934016
242	Phosphorylation	LPRSLDFTELDVAAE ECCCCCCCHHHHHHH	34.99	28555341
287	Acetylation	TYVHFQGKMKGFSLL EEEEECCEECCEEEE	27.01	30586881
304	N-linked_Glycosylation	PQEFWVDNSTSVSVP CCEEEECCCCCCCCE	37.25	9757569
304	N-linked_Glycosylation	PQEFWVDNSTSVSVP CCEEEECCCCCCCCE	37.25	3934016
328	N-linked_Glycosylation	HWSDIQDNFSVTQVP CHHHCCCCCEECCCC	18.08	9757569
328	N-linked_Glycosylation	HWSDIQDNFSVTQVP CHHHCCCCCEECCCC	18.08	3934016
440	O-linked_Glycosylation	EADEREPTESTQQLN CCCCCCCCCCCHHCC	37.50	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANGT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
34	D	Carboxylation		17138938
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANGT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EWS_HUMAN	EWSR1	physical	16189514
GSDMB_HUMAN	GSDMB	physical	21988832
RENI_HUMAN	REN	physical	20927107
RENR_HUMAN	ATP6AP2	physical	20927107
NDUA3_HUMAN	NDUFA3	physical	28514442
CALX_HUMAN	CANX	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
145500	Essential hypertension (EHT)
267430	Renal tubular dysgenesis (RTD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANGT_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-47, AND MASS SPECTROMETRY.	16335952 [Abstract]
"Processing of rat and human angiotensinogen precursors by microsomalmembranes."; Campbell D.J., Bouhnik J., Coezy E., Menard J., Corvol P.; Mol. Cell. Endocrinol. 43:31-40(1985). Cited for: GLYCOSYLATION AT ASN-47; ASN-170; ASN-304 AND ASN-328.	3934016 [Abstract]

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