| UniProt ID | GSDMB_HUMAN | |
|---|---|---|
| UniProt AC | Q8TAX9 | |
| Protein Name | Gasdermin-B | |
| Gene Name | GSDMB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 411 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytosol . Cell membrane . Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells. | |
| Protein Description | The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. [PubMed: 27281216 The physiological relevance of this observation is unknown (Probable] | |
| Protein Sequence | MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELAEGPTSVSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | Phosphorylation | TLMDILDTDGDKWLD CHHHHHCCCCCHHHH | 38.14 | 18452278 | |
| 107 | Phosphorylation | LPKEITISGSFQGFH CCCEEEEEECCCCCC | 21.53 | 27251275 | |
| 109 | Phosphorylation | KEITISGSFQGFHHQ CEEEEEECCCCCCCC | 13.96 | 27251275 | |
| 145 | Phosphorylation | LKRELPFSFRSINTR CCCCCCCCEECCCCH | 20.15 | 24719451 | |
| 156 | Phosphorylation | INTRENLYLVTETLE CCCHHCEEEEEECHH | 15.65 | - | |
| 169 | O-linked_Glycosylation | LETVKEETLKSDRQY HHHHHHHHHCCCHHH | 40.35 | 30620550 | |
| 219 (in isoform 4) | Phosphorylation | - | 20.31 | 27174698 | |
| 219 (in isoform 6) | Phosphorylation | - | 20.31 | 27174698 | |
| 240 | Phosphorylation | KSFPEGKSLGSEDSR CCCCCCCCCCCHHHH | 49.14 | 29802988 | |
| 243 | Phosphorylation | PEGKSLGSEDSRNMK CCCCCCCCHHHHHHH | 43.45 | 29802988 | |
| 260 | Ubiquitination | LEDMESVLKDLTEEK HHHHHHHHHHCCHHH | 5.07 | 29967540 | |
| 269 | Ubiquitination | DLTEEKRKDVLNSLA HCCHHHHHHHHHHHH | 64.36 | 29967540 | |
| 273 | Ubiquitination | EKRKDVLNSLAKCLG HHHHHHHHHHHHHHC | 34.52 | 29967540 | |
| 274 | Phosphorylation | KRKDVLNSLAKCLGK HHHHHHHHHHHHHCC | 26.08 | 20363803 | |
| 282 | Ubiquitination | LAKCLGKEDIRQDLE HHHHHCCHHHHHHHH | 57.80 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GSDMB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GSDMB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GSDMB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| ZEP1_HUMAN | HIVEP1 | physical | 21988832 | |
| A1AG1_HUMAN | ORM1 | physical | 21988832 | |
| A1AT_HUMAN | SERPINA1 | physical | 21988832 | |
| IBP2_HUMAN | IGFBP2 | physical | 21988832 | |
| PEBP1_HUMAN | PEBP1 | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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