IBP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IBP2_HUMAN
• UniProt AC: P18065
• Protein Name: Insulin-like growth factor-binding protein 2
• Gene Name: IGFBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Subcellular Localization: Secreted.
• Protein Description: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors..
• Protein Sequence: MLPRVGCPALPLPPPPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	EGEACGVYTPRCGQG CCCCCEEECCCCCCC	9.05	22210691
102	Phosphorylation	GEACGVYTPRCGQGL CCCCEEECCCCCCCC	11.23	22210691
142	Phosphorylation	RDAEYGASPEQVADN HCCCCCCCHHHHCCC	25.30	17496250
142	O-linked_Glycosylation	RDAEYGASPEQVADN HCCCCCCCHHHHCCC	25.30	OGP
145	Phosphorylation	EYGASPEQVADNGDD CCCCCHHHHCCCCCC	38.80	27251275
154	O-linked_Glycosylation	ADNGDDHSEGGLVEN CCCCCCCCCCCCHHH	44.95	OGP
166	O-linked_Glycosylation	VENHVDSTMNMLGGG HHHHHHCCCCCCCCC	14.22	OGP
196	Phosphorylation	AVFREKVTEQHRQMG HHHHHHHHHHHHHHC	40.78	-
207	Acetylation	RQMGKGGKHHLGLEE HHHCCCCCCCCCCCC	36.20	18529855
225	O-linked_Glycosylation	LRPPPARTPCQQELD CCCCCCCCCCHHHHH	30.44	OGP
292	Ubiquitination	CVNPNTGKLIQGAPT EECCCCCCEECCCCC	40.14	-
299	Phosphorylation	KLIQGAPTIRGDPEC CEECCCCCCCCCCCC	23.83	22496350
299	O-linked_Glycosylation	KLIQGAPTIRGDPEC CEECCCCCCCCCCCC	23.83	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW8	Q8N3Y1	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IBP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IBP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IN80B_HUMAN	INO80B	physical	19095771
EGFR_HUMAN	EGFR	physical	25893308

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.