| UniProt ID | IN80B_HUMAN | |
|---|---|---|
| UniProt AC | Q9C086 | |
| Protein Name | INO80 complex subunit B | |
| Gene Name | INO80B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 356 | |
| Subcellular Localization | Nucleus . Nucleus, nucleolus . | |
| Protein Description | Induces growth and cell cycle arrests at the G1 phase of the cell cycle.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.. | |
| Protein Sequence | MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSKLWRRGS ------CCCCCCCCC | 36.13 | 26074081 | |
| 9 | Phosphorylation | SKLWRRGSTSGAMEA CCCCCCCCCCCCCCC | 20.00 | 26074081 | |
| 10 | Phosphorylation | KLWRRGSTSGAMEAP CCCCCCCCCCCCCCC | 33.72 | 25849741 | |
| 11 | Phosphorylation | LWRRGSTSGAMEAPE CCCCCCCCCCCCCCC | 26.67 | 29496963 | |
| 26 | Phosphorylation | PGEALELSLAGAHGH CCCCEEHHHHHHCCC | 13.54 | 23882029 | |
| 60 | Phosphorylation | QEEDAGPTQPSPAKP CCCCCCCCCCCCCCC | 52.79 | 23927012 | |
| 63 | Phosphorylation | DAGPTQPSPAKPQLK CCCCCCCCCCCCCEE | 27.89 | 29255136 | |
| 82 | O-linked_Glycosylation | LGGQVLGTKSVPTFT ECCEEECCCCCCEEE | 18.91 | OGP | |
| 84 | Phosphorylation | GQVLGTKSVPTFTVI CEEECCCCCCEEEEC | 32.92 | 20873877 | |
| 87 | Phosphorylation | LGTKSVPTFTVIPEG ECCCCCCEEEECCCC | 29.77 | 29116813 | |
| 89 | Phosphorylation | TKSVPTFTVIPEGPR CCCCCEEEECCCCCC | 21.72 | 28464451 | |
| 97 | Phosphorylation | VIPEGPRSPSPLMVV ECCCCCCCCCCEEEE | 32.63 | 22617229 | |
| 99 | Phosphorylation | PEGPRSPSPLMVVDN CCCCCCCCCEEEECC | 31.73 | 22617229 | |
| 119 | Phosphorylation | EGVPLEQYRAWLDED CCCCHHHHHHHHCCC | 7.91 | 22777824 | |
| 127 | Phosphorylation | RAWLDEDSNLSPSPL HHHHCCCCCCCCCCH | 37.31 | 30266825 | |
| 130 | Phosphorylation | LDEDSNLSPSPLRDL HCCCCCCCCCCHHHC | 27.81 | 22167270 | |
| 132 | Phosphorylation | EDSNLSPSPLRDLSG CCCCCCCCCHHHCCC | 32.94 | 22167270 | |
| 138 | Phosphorylation | PSPLRDLSGGLGGQE CCCHHHCCCCCCCCH | 34.79 | 25159151 | |
| 168 | Sumoylation | LDDNGDLKKEINERL CCCCCCHHHHHHHHH | 53.77 | 17000644 | |
| 168 | Sumoylation | LDDNGDLKKEINERL CCCCCCHHHHHHHHH | 53.77 | - | |
| 192 | Phosphorylation | QKARSQPSPMLPLPV HHHHCCCCCCCCCCC | 18.46 | 24719451 | |
| 215 | Sumoylation | LTEEMLLKREERARK CCHHHHHHHHHHHHH | 54.52 | 17000644 | |
| 215 | Sumoylation | LTEEMLLKREERARK CCHHHHHHHHHHHHH | 54.52 | - | |
| 243 | Phosphorylation | NQTIERLTKTAATSG CHHHHHHHHHHHHCC | 32.35 | 20068231 | |
| 245 | Phosphorylation | TIERLTKTAATSGRG HHHHHHHHHHHCCCC | 19.11 | 20068231 | |
| 248 | Phosphorylation | RLTKTAATSGRGGRG HHHHHHHHCCCCCCC | 29.29 | 20068231 | |
| 249 | Phosphorylation | LTKTAATSGRGGRGG HHHHHHHCCCCCCCC | 23.05 | 20068231 | |
| 251 | Methylation | KTAATSGRGGRGGAR HHHHHCCCCCCCCCC | 44.13 | 115920685 | |
| 254 | Methylation | ATSGRGGRGGARGER HHCCCCCCCCCCCCC | 43.10 | 115920689 | |
| 258 | Methylation | RGGRGGARGERRGGR CCCCCCCCCCCCCCC | 51.27 | 115920693 | |
| 325 | Phosphorylation | RRYACSRTGQALCSL CCCCCCHHHHHHHHH | 19.83 | 28555341 | |
| 331 | Phosphorylation | RTGQALCSLQCYRIN HHHHHHHHHEEEEEE | 23.48 | - | |
| 335 | Phosphorylation | ALCSLQCYRINLQMR HHHHHEEEEEEEEEC | 11.10 | - | |
| 351 | Phosphorylation | GGPEGPGSPLLAT-- CCCCCCCCCCCCC-- | 18.60 | 23401153 | |
| 356 | Phosphorylation | PGSPLLAT------- CCCCCCCC------- | 38.83 | 30266825 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IN80B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IN80B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IN80B_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-130 ANDSER-132, AND MASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-99; SER-130 ANDSER-132, AND MASS SPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND MASSSPECTROMETRY. | |
