IN80C_HUMAN - dbPTM
IN80C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IN80C_HUMAN
UniProt AC Q6PI98
Protein Name INO80 complex subunit C
Gene Name INO80C
Organism Homo sapiens (Human).
Sequence Length 192
Subcellular Localization Nucleus .
Protein Description Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
Protein Sequence MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKKASASSFAQGISMEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationAQIPIVATTSTPGIV
CCCCEEEECCCCCCC		15.4722199227
11PhosphorylationQIPIVATTSTPGIVR
CCCEEEECCCCCCCC		22.3629255136
12PhosphorylationIPIVATTSTPGIVRN
CCEEEECCCCCCCCC		28.4029255136
13PhosphorylationPIVATTSTPGIVRNS
CEEEECCCCCCCCCC		24.3629255136
13 (in isoform 4)Phosphorylation-24.36-
20PhosphorylationTPGIVRNSKKRPASP
CCCCCCCCCCCCCCC		29.0526074081
21UbiquitinationPGIVRNSKKRPASPS
CCCCCCCCCCCCCCC		57.2417370265
22UbiquitinationGIVRNSKKRPASPSH
CCCCCCCCCCCCCCC		64.5317370265
26PhosphorylationNSKKRPASPSHNGSS
CCCCCCCCCCCCCCC		29.6223401153
26 (in isoform 4)Phosphorylation-29.6224719451
28PhosphorylationKKRPASPSHNGSSGG
CCCCCCCCCCCCCCC		27.3923927012
32PhosphorylationASPSHNGSSGGGYGA
CCCCCCCCCCCCCCC		31.0025159151
33PhosphorylationSPSHNGSSGGGYGAS
CCCCCCCCCCCCCCC		42.7423927012
37PhosphorylationNGSSGGGYGASKKKK
CCCCCCCCCCCHHHC		16.8823403867
37 (in isoform 4)Phosphorylation-16.88-
40PhosphorylationSGGGYGASKKKKASA
CCCCCCCCHHHCCCH		40.4223403867
41AcetylationGGGYGASKKKKASAS
CCCCCCCHHHCCCHH		68.9912435411
41UbiquitinationGGGYGASKKKKASAS
CCCCCCCHHHCCCHH		68.9917370265
46PhosphorylationASKKKKASASSFAQG
CCHHHCCCHHHHHHC		37.2528555341
49PhosphorylationKKKASASSFAQGISM
HHCCCHHHHHHCCCH		25.0730576142
55PhosphorylationSSFAQGISMEAMSEN
HHHHHCCCHHHHHCC		19.8628348404
60PhosphorylationGISMEAMSENKMVPS
CCCHHHHHCCCCCCC		45.1030576142
84UbiquitinationAAKPLPFKDPNFVHS
CCCCCCCCCCCCCCC		71.04-
109UbiquitinationNRTWKNLKQILASER
CCHHHHHHHHHHHCC		44.69-
114PhosphorylationNLKQILASERALPWQ
HHHHHHHHCCCCCCC		24.9524719451
137UbiquitinationIDAPPSFKPAKKYSD
CCCCCCCCCCCCCCC		48.69-
141UbiquitinationPSFKPAKKYSDVSGL
CCCCCCCCCCCHHHH		52.68-
162PhosphorylationPQSKLRFSTIEEFSY
HHHCCCCCHHHHHHH		23.2626074081
163PhosphorylationQSKLRFSTIEEFSYI
HHCCCCCHHHHHHHH		29.6926074081
168PhosphorylationFSTIEEFSYIRRLPS
CCHHHHHHHHHCCCH		23.9524719451
169PhosphorylationSTIEEFSYIRRLPSD
CHHHHHHHHHCCCHH		12.0826074081
175PhosphorylationSYIRRLPSDVVTGYL
HHHHCCCHHHHHHHH		47.8626074081
179PhosphorylationRLPSDVVTGYLALRK
CCCHHHHHHHHHHHH		21.6926074081
181PhosphorylationPSDVVTGYLALRKAT
CHHHHHHHHHHHHHC		4.5726074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IN80C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IN80C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IN80C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IN80E_HUMANINO80Ephysical
17721549
RUVB1_HUMANRUVBL1physical
17721549
RUVB2_HUMANRUVBL2physical
17721549
ACL6A_HUMANACTL6Aphysical
17721549
TYY1_HUMANYY1physical
17721549
INO80_HUMANINO80physical
17721549
NFRKB_HUMANNFRKBphysical
17721549
TFPT_HUMANTFPTphysical
17721549
ARP5_HUMANACTR5physical
17721549
ARP8_HUMANACTR8physical
17721549
IN80B_HUMANINO80Bphysical
17721549
INO80_HUMANINO80physical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IN80C_HUMAN

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-21; LYS-22 AND LYS-41,AND MASS SPECTROMETRY.

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