ARP5_HUMAN - dbPTM
ARP5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARP5_HUMAN
UniProt AC Q9H9F9
Protein Name Actin-related protein 5
Gene Name ACTR5
Organism Homo sapiens (Human).
Sequence Length 607
Subcellular Localization Nucleus . Cytoplasm . Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli
excluded from chromosomes as mitosis progresses (PubMed:18163988).
Protein Description Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair..
Protein Sequence MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLKEHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69MethylationRAVCARGRGGARGAS
EEECCCCCCCCCCCC		34.51-
73MethylationARGRGGARGASGPQV
CCCCCCCCCCCCCCH		44.48-
76PhosphorylationRGGARGASGPQVGNA
CCCCCCCCCCCHHHC		54.5527050516
86PhosphorylationQVGNALGSLEPLRWM
CHHHCCCCCCCHHHH		30.3450563365
96PhosphorylationPLRWMLRSPFDRNVP
CHHHHHCCCCCCCCC		26.4228555341
144PhosphorylationAVCNPLYSRQMMSEL
HHHCHHHCHHHHHHH		24.5824719451
175AcetylationLFSFYHNKPKNSMCS
HHHHHCCCCCCCCCC		44.0225953088
175UbiquitinationLFSFYHNKPKNSMCS
HHHHHCCCCCCCCCC		44.02-
229UbiquitinationLQRLLQLKYPGHLAA
HHHHHCCCCCCCEEH		36.12-
275UbiquitinationYYENNVHKMQLPFSS
HHHCCCCCCCCCCCH		24.8629967540
283SumoylationMQLPFSSKLLGSTLT
CCCCCCHHHHCCCCC		46.6728112733
283UbiquitinationMQLPFSSKLLGSTLT
CCCCCCHHHHCCCCC		46.6722817900
287PhosphorylationFSSKLLGSTLTSEEK
CCHHHHCCCCCHHHH		21.8825954137
288PhosphorylationSSKLLGSTLTSEEKQ
CHHHHCCCCCHHHHH		32.0525954137
290PhosphorylationKLLGSTLTSEEKQER
HHHCCCCCHHHHHHH		33.8926270265
291PhosphorylationLLGSTLTSEEKQERR
HHCCCCCHHHHHHHH		47.0421815630
294UbiquitinationSTLTSEEKQERRQQQ
CCCCHHHHHHHHHHH		54.1029967540
390SumoylationEVDVVDSKPETPDLE
EEEEECCCCCCCCHH		42.27-
459PhosphorylationPEIIFQPSLIGEEQA
CEEEECHHHCCHHHH		23.1046158863
509UbiquitinationGMKARMEKELLEMRP
CHHHHHHHHHHHHCC		44.30-
574PhosphorylationEHCASNIYVPIRLPK
HHHCCCEEEEEECCC		12.3927642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARP5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARP5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARP5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IN80E_HUMANINO80Ephysical
17721549
RUVB1_HUMANRUVBL1physical
17721549
RUVB2_HUMANRUVBL2physical
17721549
ACL6A_HUMANACTL6Aphysical
17721549
IN80C_HUMANINO80Cphysical
17721549
TYY1_HUMANYY1physical
17721549
INO80_HUMANINO80physical
17721549
NFRKB_HUMANNFRKBphysical
17721549
TFPT_HUMANTFPTphysical
17721549
ARP8_HUMANACTR8physical
17721549
IN80B_HUMANINO80Bphysical
17721549
UCHL5_HUMANUCHL5physical
17721549
IN80D_HUMANINO80Dphysical
17721549
MCRS1_HUMANMCRS1physical
17721549
RUVB1_HUMANRUVBL1physical
22939629
INO80_HUMANINO80physical
20855601
DDB1_HUMANDDB1physical
20855601
INO80_HUMANINO80physical
26344197
ACL6A_HUMANACTL6Aphysical
26496610
KLF5_HUMANKLF5physical
26496610
FMNL1_HUMANFMNL1physical
26496610
IF4G1_HUMANEIF4G1physical
26496610
NFRKB_HUMANNFRKBphysical
26496610
PPM1A_HUMANPPM1Aphysical
26496610
TYY1_HUMANYY1physical
26496610
ZN148_HUMANZNF148physical
26496610
RUVB1_HUMANRUVBL1physical
26496610
EXO1_HUMANEXO1physical
26496610
KNTC1_HUMANKNTC1physical
26496610
TOM20_HUMANTOMM20physical
26496610
MCRS1_HUMANMCRS1physical
26496610
HEXI1_HUMANHEXIM1physical
26496610
RUVB2_HUMANRUVBL2physical
26496610
FAF2_HUMANFAF2physical
26496610
DICER_HUMANDICER1physical
26496610
INT7_HUMANINTS7physical
26496610
NARF_HUMANNARFphysical
26496610
TFPT_HUMANTFPTphysical
26496610
UCHL5_HUMANUCHL5physical
26496610
INO80_HUMANINO80physical
26496610
IN80D_HUMANINO80Dphysical
26496610
PLXA3_HUMANPLXNA3physical
26496610
DEFM_HUMANPDFphysical
26496610
IN80B_HUMANINO80Bphysical
26496610
TBRG1_HUMANTBRG1physical
26496610
MILK1_HUMANMICALL1physical
26496610
ARP8_HUMANACTR8physical
26496610
IN80C_HUMANINO80Cphysical
26496610
SPICE_HUMANSPICE1physical
26496610
IN80E_HUMANINO80Ephysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARP5_HUMAN

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Related Literatures of Post-Translational Modification

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