INT7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT7_HUMAN
• UniProt AC: Q9NVH2
• Protein Name: Integrator complex subunit 7
• Gene Name: INTS7
• Organism: Homo sapiens (Human).
• Sequence Length: 962
• Subcellular Localization: Nucleus . Chromosome . Cytoplasm . Localizes to sites of DNA damage in a H2AX-independent manner.
• Protein Description: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase. [PubMed: 21659603 May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex]
• Protein Sequence: MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASNSTKSFL -----CCCCCCHHHH	29.98	20860994
5	Phosphorylation	---MASNSTKSFLAD ---CCCCCCHHHHHC	34.42	20860994
6	Phosphorylation	--MASNSTKSFLADA --CCCCCCHHHHHCC	34.65	24719451
31	Ubiquitination	SALMELDKGLRSGKL HHHHHHHHHHHCCCH	72.90	22817900
31 (in isoform 1)	Ubiquitination	-	72.90	21890473
31 (in isoform 2)	Ubiquitination	-	72.90	21890473
31 (in isoform 3)	Ubiquitination	-	72.90	21890473
37	Acetylation	DKGLRSGKLGEQCEA HHHHHCCCHHHHCCH	55.34	25953088
37	Ubiquitination	DKGLRSGKLGEQCEA HHHHHCCCHHHHCCH	55.34	24816145
54	Ubiquitination	RFPRLFQKYPFPILI HCHHHHHHCCCCEEE	47.78	-
82 (in isoform 4)	Phosphorylation	-	2.45	-
92	Ubiquitination	KVTQQSEKHLEKILN HHHHCCHHHHHHHCC	59.75	29967540
96	Ubiquitination	QSEKHLEKILNVDEF CCHHHHHHHCCHHHH	59.87	29967540
105	Ubiquitination	LNVDEFVKRIFSVIH CCHHHHHHHHHHHHH	45.13	23000965
105 (in isoform 1)	Ubiquitination	-	45.13	21890473
105 (in isoform 2)	Ubiquitination	-	45.13	21890473
105 (in isoform 3)	Ubiquitination	-	45.13	21890473
109	Phosphorylation	EFVKRIFSVIHSNDP HHHHHHHHHHHCCCH	20.14	24043423
113	Phosphorylation	RIFSVIHSNDPVARA HHHHHHHCCCHHHHH	31.63	21964256
122	Phosphorylation	DPVARAITLRMLGSL CHHHHHHHHHHHHHH	13.81	21964256
131	Phosphorylation	RMLGSLASIIPERKN HHHHHHHHHCCHHCC	26.75	22496350
145	Ubiquitination	NAHHSIRQSLDSHDN CHHHHHHHHCCCCCC	46.83	22817900
147	Ubiquitination	HHSIRQSLDSHDNVE HHHHHHHCCCCCCHH	6.23	22817900
181	Phosphorylation	VGICNKISEMIQGLA HHHHHHHHHHHHCCC	23.79	-
194	Ubiquitination	LATPVDLKLKLIPIL CCCCHHHHHHHHHHH	38.83	21906983
194 (in isoform 1)	Ubiquitination	-	38.83	21890473
194 (in isoform 2)	Ubiquitination	-	38.83	21890473
194 (in isoform 3)	Ubiquitination	-	38.83	21890473
196	Ubiquitination	TPVDLKLKLIPILQH CCHHHHHHHHHHHHH	42.66	22817900
223	Phosphorylation	QLLQQLVTSYPSTKM HHHHHHHHCCCCCCE	31.00	24043423
224	Phosphorylation	LLQQLVTSYPSTKMV HHHHHHHCCCCCCEE	27.80	24043423
225	Phosphorylation	LQQLVTSYPSTKMVI HHHHHHCCCCCCEEE	7.58	24043423
227	Phosphorylation	QLVTSYPSTKMVIVS HHHHCCCCCCEEEEE	32.21	24043423
228	Phosphorylation	LVTSYPSTKMVIVSL HHHCCCCCCEEEEEH	20.75	24043423
228	Ubiquitination	LVTSYPSTKMVIVSL HHHCCCCCCEEEEEH	20.75	21963094
233	Ubiquitination	PSTKMVIVSLHTFTL CCCCEEEEEHHHHHH	3.20	22817900
277	Ubiquitination	RLAIQDLKLLANKTP HHHHHHHHHHHCCCC	50.14	21906983
277 (in isoform 1)	Ubiquitination	-	50.14	21890473
277 (in isoform 2)	Ubiquitination	-	50.14	21890473
277 (in isoform 3)	Ubiquitination	-	50.14	21890473
282	Ubiquitination	DLKLLANKTPHTWSR HHHHHHCCCCCCCCH	58.80	22817900
297	Ubiquitination	ENIQALCECALQTPY HHHHHHHHHHHCCCH	24.55	21963094
313	Phosphorylation	SLKLGMLSVLSTLSG HHHHHHHHHHHHHCC	16.48	-
321	Phosphorylation	VLSTLSGTIAIKHYF HHHHHCCCEEEEEEE	12.12	-
327	Phosphorylation	GTIAIKHYFSIVPGN CCEEEEEEEEECCCC	8.26	21406692
329	Phosphorylation	IAIKHYFSIVPGNVS EEEEEEEEECCCCCC	18.60	20068231
336	Phosphorylation	SIVPGNVSSSPRSSD EECCCCCCCCCCCCH	29.15	25849741
337	Phosphorylation	IVPGNVSSSPRSSDL ECCCCCCCCCCCCHH	39.83	25159151
338	Phosphorylation	VPGNVSSSPRSSDLV CCCCCCCCCCCCHHH	19.47	25159151
341	Phosphorylation	NVSSSPRSSDLVKLA CCCCCCCCCHHHHHH	31.43	24247654
346	Ubiquitination	PRSSDLVKLAQECCY CCCCHHHHHHHHHHH	45.46	21963094
369	Ubiquitination	HGVRVLTNITVSCQE HCEEEEEEEEEECCH	24.63	29967540
418	Methylation	IALNCMVKLAKGRPH HHHHHHHHHHCCCCC	18.82	-
418	Ubiquitination	IALNCMVKLAKGRPH HHHHHHHHHHCCCCC	18.82	29967540
461	Ubiquitination	AAIAMQLPVLGDGML HHHHHCCCCCCCCHH	11.46	22817900
465	Ubiquitination	MQLPVLGDGMLGDLM HCCCCCCCCHHHHHH	34.86	21963094
475	Phosphorylation	LGDLMELYKVIGRSA HHHHHHHHHHHCCCC	7.01	21214269
510	Ubiquitination	KALSVESKAVIKQQL CCCCCCCHHHHHHHH	32.92	22817900
514	Ubiquitination	VESKAVIKQQLESVS CCCHHHHHHHHHHCC	25.95	21963094
519	Phosphorylation	VIKQQLESVSNGWTV HHHHHHHHCCCCHHH	39.16	24719451
527	Phosphorylation	VSNGWTVYRIARQAS CCCCHHHHHHHHHHH	6.74	24719451
534	Phosphorylation	YRIARQASRMGNHDM HHHHHHHHHCCCHHH	17.92	-
550	Ubiquitination	KELYQSLLTQVASEH HHHHHHHHHHHHHHH	3.69	29967540
599	Ubiquitination	ESLKFYHKGIASLTA HHHCHHHHCHHHHCC	40.40	29967540
623	Ubiquitination	FQCEFVKLRIDLLQA HCCEEHHHHHHHHHH	4.95	24816145
643	Phosphorylation	CTCNSLKTSPPPAIA HHHHHCCCCCCCCHH	52.32	25627689
644	Phosphorylation	TCNSLKTSPPPAIAT HHHHCCCCCCCCHHH	33.55	25627689
672	Ubiquitination	GRISNQMKQSMEEFR HHHHHHHHHHHHHHH	29.47	24816145
672 (in isoform 2)	Ubiquitination	-	29.47	-
674	Phosphorylation	ISNQMKQSMEEFRSL HHHHHHHHHHHHHHH	23.73	22210691
683	Phosphorylation	EEFRSLASRYGDLYQ HHHHHHHHHHHHHHH	31.18	22210691
692	Phosphorylation	YGDLYQASFDADSAT HHHHHHHHCCCCCCC	14.24	29038488
697	Phosphorylation	QASFDADSATLRNVE HHHCCCCCCCCCCHH	25.52	29038488
699	Phosphorylation	SFDADSATLRNVELQ HCCCCCCCCCCHHHH	30.15	22210691
749	Ubiquitination	SEYERRMMSVYNHVL CHHHHHHHHHHHHHH	2.02	21963094
756	Ubiquitination	MSVYNHVLEEVESLN HHHHHHHHHHHHHHC	3.45	29967540
778	Ubiquitination	YMHTACLCNAIIALL HHHHHHHHHHHHHHH	3.04	21963094
784	Ubiquitination	LCNAIIALLKVPLSF HHHHHHHHHHCCHHH	3.15	21963094
790	Phosphorylation	ALLKVPLSFQRYFFQ HHHHCCHHHHHHHHH	17.17	24719451
791	Ubiquitination	LLKVPLSFQRYFFQK HHHCCHHHHHHHHHH	6.71	21890473
791	Ubiquitination	LLKVPLSFQRYFFQK HHHCCHHHHHHHHHH	6.71	21890473
794	Phosphorylation	VPLSFQRYFFQKLQS CCHHHHHHHHHHHHH	9.65	-
798	Ubiquitination	FQRYFFQKLQSTSIK HHHHHHHHHHHCCEE	43.25	21963094
802	Phosphorylation	FFQKLQSTSIKLALS HHHHHHHCCEEEECC	22.85	26434552
805	Ubiquitination	KLQSTSIKLALSPSP HHHHCCEEEECCCCC	27.72	29967540
809	Phosphorylation	TSIKLALSPSPRNPA CCEEEECCCCCCCCC	20.09	30266825
811	Phosphorylation	IKLALSPSPRNPAEP EEEECCCCCCCCCCC	32.87	30266825
812	Ubiquitination	KLALSPSPRNPAEPI EEECCCCCCCCCCCC	43.37	23000965
818	Ubiquitination	SPRNPAEPIAVQNNQ CCCCCCCCCEEECCC	23.19	21890473
818	Ubiquitination	SPRNPAEPIAVQNNQ CCCCCCCCCEEECCC	23.19	23000965
820	Ubiquitination	RNPAEPIAVQNNQQL CCCCCCCEEECCCEE	13.93	21890473
820 (in isoform 3)	Ubiquitination	-	13.93	21890473
826	Ubiquitination	IAVQNNQQLALKVEG CEEECCCEEEEEEEE	30.72	21890473
826 (in isoform 2)	Ubiquitination	-	30.72	21890473
834	Ubiquitination	LALKVEGVVQHGSKP EEEEEEEEECCCCCC	2.07	21963094
840	Acetylation	GVVQHGSKPGLFRKI EEECCCCCCCHHHHH	47.93	7469397
840	Ubiquitination	GVVQHGSKPGLFRKI EEECCCCCCCHHHHH	47.93	22817900
840 (in isoform 1)	Ubiquitination	-	47.93	21890473
841	Ubiquitination	VVQHGSKPGLFRKIQ EECCCCCCCHHHHHH	46.55	23000965
846	Acetylation	SKPGLFRKIQSVCLN CCCCHHHHHHHHHHH	37.45	7975737
847	Ubiquitination	KPGLFRKIQSVCLNV CCCHHHHHHHHHHHH	3.00	23000965
847 (in isoform 3)	Ubiquitination	-	3.00	21890473
853	Ubiquitination	KIQSVCLNVSSTLQS HHHHHHHHHHHHHHC	26.88	23000965
853 (in isoform 2)	Ubiquitination	-	26.88	21890473
855	Phosphorylation	QSVCLNVSSTLQSKS HHHHHHHHHHHHCCC	19.28	29888752
856	Phosphorylation	SVCLNVSSTLQSKSG HHHHHHHHHHHCCCC	28.93	29888752
857	Phosphorylation	VCLNVSSTLQSKSGQ HHHHHHHHHHCCCCC	22.70	29888752
860	Phosphorylation	NVSSTLQSKSGQDYK HHHHHHHCCCCCCCE	31.72	29888752
861	Ubiquitination	VSSTLQSKSGQDYKI HHHHHHCCCCCCCEE	45.72	23000965
867	Ubiquitination	SKSGQDYKIPIDNMT CCCCCCCEEECHHCC	50.74	23000965
867 (in isoform 1)	Ubiquitination	-	50.74	21890473
870	Ubiquitination	GQDYKIPIDNMTNEM CCCCEEECHHCCHHH	7.33	27667366
874	Phosphorylation	KIPIDNMTNEMEQRV EEECHHCCHHHHHHC	33.99	20068231
876	Ubiquitination	PIDNMTNEMEQRVEP ECHHCCHHHHHHCCC	34.62	21890473
880	Ubiquitination	MTNEMEQRVEPHNDY CCHHHHHHCCCCCCC	22.81	22505724
897	Ubiquitination	TQFLLNFAILGTHNI HHHHHHCHHHCCCCE	8.60	23000965
899	Ubiquitination	FLLNFAILGTHNITV HHHHCHHHCCCCEEE	6.09	27667366
903	Ubiquitination	FAILGTHNITVESSV CHHHCCCCEEECCCE	31.31	23000965
905	Ubiquitination	ILGTHNITVESSVKD HHCCCCEEECCCEEC	24.44	27667366
909	Ubiquitination	HNITVESSVKDANGI CCEEECCCEECCCCE	21.49	22505724
909 (in isoform 3)	Ubiquitination	-	21.49	21890473
915	Ubiquitination	SSVKDANGIVWKTGP CCEECCCCEEEECCC	19.97	22505724
915 (in isoform 2)	Ubiquitination	-	19.97	21890473
919	Ubiquitination	DANGIVWKTGPRTTI CCCCEEEECCCCEEE	32.48	27667366
929	Acetylation	PRTTIFVKSLEDPYS CCEEEEEEECCCHHH	38.28	26051181
929	Ubiquitination	PRTTIFVKSLEDPYS CCEEEEEEECCCHHH	38.28	29967540
929 (in isoform 1)	Ubiquitination	-	38.28	21890473
935	Phosphorylation	VKSLEDPYSQQIRLQ EEECCCHHHHHHHHH	31.28	21945579
936	Phosphorylation	KSLEDPYSQQIRLQQ EECCCHHHHHHHHHH	22.46	21945579
955	Ubiquitination	QPLQQQQQRNAYTRF HHHHHHHHHHHHHCC	35.94	27667366
965	Ubiquitination	AYTRF---------- HHHCC----------		22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INT8_HUMAN	INTS8	physical	22939629
CG026_HUMAN	C7orf26	physical	26344197
INT11_HUMAN	CPSF3L	physical	26344197
INT2_HUMAN	INTS2	physical	26344197
INT5_HUMAN	INTS5	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.