INT8_HUMAN - dbPTM
INT8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INT8_HUMAN
UniProt AC Q75QN2
Protein Name Integrator complex subunit 8
Gene Name INTS8
Organism Homo sapiens (Human).
Sequence Length 995
Subcellular Localization Nucleus .
Protein Description Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes..
Protein Sequence MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQSVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIAEECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQADIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAEAADRE
------CCHHHHHHH		34.5127251275
12PhosphorylationAADREAATSSRPCTP
HHHHHHHHCCCCCCC		33.9925159151
13PhosphorylationADREAATSSRPCTPP
HHHHHHHCCCCCCCC		21.4425159151
14PhosphorylationDREAATSSRPCTPPQ
HHHHHHCCCCCCCCC		35.5725159151
18PhosphorylationATSSRPCTPPQTCWF
HHCCCCCCCCCCHHH		40.4627273156
22PhosphorylationRPCTPPQTCWFEFLL
CCCCCCCCHHHHHHH		19.9225159151
32PhosphorylationFEFLLEESLLEKHLR
HHHHHHHHHHHHHCC		28.9524719451
53UbiquitinationAPVQLIVQFLEQASK
HHHHHHHHHHHHCCC		30.1622817900
56UbiquitinationQLIVQFLEQASKPSV
HHHHHHHHHCCCCCC		45.4422817900
62PhosphorylationLEQASKPSVNEQNQV
HHHCCCCCCCCCCCC		41.1120068231
80UbiquitinationPDNKRNRILKLLALK
CCCHHHHHHHHHHHH		4.5522817900
83UbiquitinationKRNRILKLLALKVAA
HHHHHHHHHHHHHHH		2.7922817900
133UbiquitinationKHVDMDLATLPPTTA
CCCCCCCCCCCCCHH		11.6522817900
135UbiquitinationVDMDLATLPPTTAMA
CCCCCCCCCCCHHHH		3.8822817900
162UbiquitinationVQSSFPVKQAKPGPP
HHHCCCCCCCCCCCC		44.7922817900
165 (in isoform 1)Ubiquitination-48.2721906983
165UbiquitinationSFPVKQAKPGPPQLS
CCCCCCCCCCCCCHH		48.2722817900
165 (in isoform 2)Ubiquitination-48.2721906983
189 (in isoform 2)Ubiquitination-41.5521906983
189UbiquitinationELTENILKVLKEQAA
HHHHHHHHHHHHHHH		41.5521906983
189 (in isoform 1)Ubiquitination-41.5521906983
192UbiquitinationENILKVLKEQAADSI
HHHHHHHHHHHHHHH		51.2522817900
210UbiquitinationEAALKLNKDLYVHTM
HHHHHCCCCHHHHHH		60.59-
233UbiquitinationEPGMVNGETESSTAG
CCCCCCCCCCCCCCC		44.1722817900
234PhosphorylationPGMVNGETESSTAGL
CCCCCCCCCCCCCCC		42.4329083192
236PhosphorylationMVNGETESSTAGLKV
CCCCCCCCCCCCCEE		40.1729083192
237PhosphorylationVNGETESSTAGLKVK
CCCCCCCCCCCCEEC		18.9529083192
238PhosphorylationNGETESSTAGLKVKT
CCCCCCCCCCCEECC		33.7429083192
239UbiquitinationGETESSTAGLKVKTE
CCCCCCCCCCEECCH		24.2222817900
242 (in isoform 2)Ubiquitination-40.5421906983
242UbiquitinationESSTAGLKVKTEEMQ
CCCCCCCEECCHHHH		40.5422817900
242 (in isoform 1)Ubiquitination-40.5421906983
244UbiquitinationSTAGLKVKTEEMQCQ
CCCCCEECCHHHHCC		48.9422817900
369UbiquitinationVLRELFKKAQQGNEA
HHHHHHHHHHHCCHH		44.0629967540
430 (in isoform 2)Ubiquitination-61.4521906983
430UbiquitinationSRSVNLEKASESLKG
HCCCCHHHHHHHHCH		61.4522817900
430 (in isoform 1)Ubiquitination-61.4521906983
436AcetylationEKASESLKGNMAAFL
HHHHHHHCHHHHHHH		58.4819811789
436 (in isoform 2)Ubiquitination-58.4821906983
436UbiquitinationEKASESLKGNMAAFL
HHHHHHHCHHHHHHH		58.4821906983
436 (in isoform 1)Ubiquitination-58.4821906983
444AcetylationGNMAAFLKNVCLGLE
HHHHHHHHHHHHCCH		40.6619811799
475UbiquitinationLLKDEERKLLVDQMR
HCCHHHHHHHHHHHH		49.8329967540
521UbiquitinationHQLILSVDPWRIRQI
EEEEEEECHHHHHHH		33.4022817900
543PhosphorylationTSERQFWTVSNKWEV
CCCCEEEEECCCCCC		18.4924425749
545PhosphorylationERQFWTVSNKWEVPS
CCEEEEECCCCCCCC		25.8924425749
552PhosphorylationSNKWEVPSVYSGVIL
CCCCCCCCEEECEEE		38.5720068231
584UbiquitinationGLHCSTVKDFSHAKQ
CCCCCCCCCHHHHHH		53.8229967540
601PhosphorylationAACLELVTEFSPKLR
HHHHHHHHHCCHHHH		43.8927251275
604PhosphorylationLELVTEFSPKLRQVM
HHHHHHCCHHHHHHH		18.2024719451
636PhosphorylationQAGERPPSDLISRVR
CCCCCCCCHHHHHHH		47.97-
645PhosphorylationLISRVRGYLEMRLPD
HHHHHHHHHHHCCCC		6.7422817900
702UbiquitinationQLLAATCKELPGPKE
HHHHHHHHCCCCCHH		58.91-
708UbiquitinationCKELPGPKESRRTAK
HHCCCCCHHHHHHHH		74.3932142685
710PhosphorylationELPGPKESRRTAKDL
CCCCCHHHHHHHHHH		32.9420068231
740PhosphorylationRGNDGRVSLIKQRES
CCCCCCEEEHHHHHC		24.0224719451
743UbiquitinationDGRVSLIKQRESTLG
CCCEEEHHHHHCHHH		48.90-
759PhosphorylationMYRSELLSFIKKLRE
HHHHHHHHHHHHHCC		37.2323532336
762UbiquitinationSELLSFIKKLREPLV
HHHHHHHHHHCCHHH		43.6822817900
882UbiquitinationVYTDQVIKRMIKCCS
CCHHHHHHHHHHHHH		36.7429967540
886UbiquitinationQVIKRMIKCCSLLNC
HHHHHHHHHHHHCCC		21.6122817900
910UbiquitinationFLREIDYKTAFKSLQ
HHHHCCHHHHHHHHH		29.63-
942 (in isoform 2)Ubiquitination-24.1221906983
959 (in isoform 1)Ubiquitination-25.5721906983
959UbiquitinationDKRQIAIKAIGQTEL
CHHHHHHHHHCCCCC		25.5722817900
985UbiquitinationAAQRRKKKFLQAMAK
HHHHHHHHHHHHHHH		55.1029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INT8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INT8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INT8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of INT8_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INT8_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASSSPECTROMETRY.

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