INT11_HUMAN - dbPTM
INT11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INT11_HUMAN
UniProt AC Q5TA45
Protein Name Integrator complex subunit 11
Gene Name INTS11 {ECO:0000312|HGNC:HGNC:26052}
Organism Homo sapiens (Human).
Sequence Length 600
Subcellular Localization Nucleus . Cytoplasm .
Protein Description Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. [PubMed: 23904267]
Protein Sequence MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationAGQDVGRSCILVSIA
CCCCCCCCEEEEEEC		10.2825332170
115UbiquitinationRKIAVDKKGEANFFT
HHHCCCCCCCCCCCC		58.4821906983
115 (in isoform 3)Ubiquitination-58.4821890473
115 (in isoform 1)Ubiquitination-58.4821890473
115SumoylationRKIAVDKKGEANFFT
HHHCCCCCCCCCCCC		58.48-
115SumoylationRKIAVDKKGEANFFT
HHHCCCCCCCCCCCC		58.48-
127UbiquitinationFFTSQMIKDCMKKVV
CCCHHHHHHHHHHHE		39.26-
133 (in isoform 2)Ubiquitination-2.52-
153PhosphorylationDELEIKAYYAGHVLG
CCEEEEEEEHHHHHE		6.7230576142
161 (in isoform 2)Ubiquitination-7.5021890473
172PhosphorylationQIKVGSESVVYTGDY
EEEECCEEEEEECCC		20.6930576142
175PhosphorylationVGSESVVYTGDYNMT
ECCEEEEEECCCCCC		11.6630576142
179 (in isoform 2)Ubiquitination-14.2621890473
188 (in isoform 2)Ubiquitination-13.7121890473
194UbiquitinationLGAAWIDKCRPNLLI
CCHHHHHHCCCCEEE		24.02-
206PhosphorylationLLITESTYATTIRDS
EEEEECCEECCCCCC		15.95-
224UbiquitinationRERDFLKKVHETVER
HHHHHHHHHHHHHHC		51.47-
234UbiquitinationETVERGGKVLIPVFA
HHHHCCCEEEEEEEE		36.37-
240 (in isoform 3)Ubiquitination-3.7921890473
258 (in isoform 3)Ubiquitination-15.1921890473
262 (in isoform 1)Ubiquitination-40.7521890473
262UbiquitinationFWERMNLKVPIYFST
HHHHCCCCCCEEEEC		40.7521906983
266PhosphorylationMNLKVPIYFSTGLTE
CCCCCCEEEECCCHH		5.84-
267 (in isoform 3)Ubiquitination-5.6621890473
274UbiquitinationFSTGLTEKANHYYKL
EECCCHHHHCEEEEE		49.61-
280UbiquitinationEKANHYYKLFIPWTN
HHHCEEEEEEEECCC		29.7421890473
280UbiquitinationEKANHYYKLFIPWTN
HHHCEEEEEEEECCC		29.7421890473
280UbiquitinationEKANHYYKLFIPWTN
HHHCEEEEEEEECCC		29.7421890473
280 (in isoform 1)Ubiquitination-29.7421890473
280UbiquitinationEKANHYYKLFIPWTN
HHHCEEEEEEEECCC		29.7421890473
289UbiquitinationFIPWTNQKIRKTFVQ
EEECCCHHHHHHHHH		46.6921890473
289UbiquitinationFIPWTNQKIRKTFVQ
EEECCCHHHHHHHHH		46.6921890473
289 (in isoform 1)Ubiquitination-46.6921890473
289UbiquitinationFIPWTNQKIRKTFVQ
EEECCCHHHHHHHHH		46.6921890473
289UbiquitinationFIPWTNQKIRKTFVQ
EEECCCHHHHHHHHH		46.6921890473
303UbiquitinationQRNMFEFKHIKAFDR
HHCCCCCCCHHHHHH		36.90-
317 (in isoform 2)Ubiquitination-29.2321890473
345UbiquitinationRKWAGNEKNMVIMPG
HHHCCCCCCEEEECC		55.10-
362UbiquitinationVQGTVGHKILSGQRK
EECCHHHHHHCCCEE		39.14-
385 (in isoform 2)Ubiquitination-20.7321890473
396 (in isoform 3)Ubiquitination-49.9021890473
399 (in isoform 2)Ubiquitination-3.2521890473
418 (in isoform 1)Ubiquitination-48.6421890473
418UbiquitinationLLVHGEAKKMEFLKQ
EEEECCHHHHHHHHH		48.6421906983
426UbiquitinationKMEFLKQKIEQELRV
HHHHHHHHHHHHHCC		46.77-
445AcetylationPANGETVTLPTSPSI
CCCCCEEECCCCCCC		34.1419608861
445PhosphorylationPANGETVTLPTSPSI
CCCCCEEECCCCCCC		34.1428655764
451PhosphorylationVTLPTSPSIPVGISL
EECCCCCCCCCCHHH		39.0128655764
464 (in isoform 3)Ubiquitination-36.9621890473
474AcetylationQGLLPEAKKPRLLHG
CCCCCCCCCCCEEEE		62.7419608861
478 (in isoform 3)Ubiquitination-5.8521890473
480AcetylationAKKPRLLHGTLIMKD
CCCCCEEEEEEEEEC		31.6119608861
482PhosphorylationKPRLLHGTLIMKDSN
CCCEEEEEEEEECCC		11.4520068231
486 (in isoform 1)Ubiquitination-51.5221890473
486UbiquitinationLHGTLIMKDSNFRLV
EEEEEEEECCCEEEE		51.5221890473
486UbiquitinationLHGTLIMKDSNFRLV
EEEEEEEECCCEEEE		51.5221890473
486UbiquitinationLHGTLIMKDSNFRLV
EEEEEEEECCCEEEE		51.5221890473
486UbiquitinationLHGTLIMKDSNFRLV
EEEEEEEECCCEEEE		51.5221890473
500UbiquitinationVSSEQALKELGLAEH
ECHHHHHHHHCCCHH		54.6421890473
500 (in isoform 1)Ubiquitination-54.6421890473
500UbiquitinationVSSEQALKELGLAEH
ECHHHHHHHHCCCHH		54.6421890473
500UbiquitinationVSSEQALKELGLAEH
ECHHHHHHHHCCCHH		54.6421890473
500UbiquitinationVSSEQALKELGLAEH
ECHHHHHHHHCCCHH		54.6421890473
532PhosphorylationETALRVYSHLKSVLK
HHHHHHHHHHHHHHH		21.3430622161
535AcetylationLRVYSHLKSVLKDHC
HHHHHHHHHHHHHHH		32.8525953088
535UbiquitinationLRVYSHLKSVLKDHC
HHHHHHHHHHHHHHH		32.85-
539UbiquitinationSHLKSVLKDHCVQHL
HHHHHHHHHHHHHCC		43.18-
589PhosphorylationELGSFLTSLLKKGLP
HHHHHHHHHHHCCCC		33.5724719451
593UbiquitinationFLTSLLKKGLPQAPS
HHHHHHHCCCCCCCC		66.70-
593AcetylationFLTSLLKKGLPQAPS
HHHHHHHCCCCCCCC		66.7025825284
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INT11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INT11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INT11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPB1_HUMANPOLR2Aphysical
16239144
INT2_HUMANINTS2physical
16239144
INT9_HUMANINTS9physical
16239144
DSE_HUMANDSEphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INT11_HUMAN

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Related Literatures of Post-Translational Modification

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