| UniProt ID | DSE_HUMAN | |
|---|---|---|
| UniProt AC | Q9UL01 | |
| Protein Name | Dermatan-sulfate epimerase | |
| Gene Name | DSE | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 958 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.. | |
| Protein Sequence | MRTHTRGAPSVFFIYLLCFVSAYITDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVHTMLSSPLEYLPPWDPKDYSARWNEIFGNNLGALAMFCVLYPENIEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFNINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDGSLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAVSKSCFSPWVGQVTEDCSSKWSKYKHDLAASCQGRVVAAEEKNGVVFIRGEGVGAYNPQLNLKNVQRNLILLHPQLLLLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGAFIRQRDGLYKMYWMDDTGYSEKATFASVTYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSIDVQSFTVHGDSQQLDVFIATSKHAYATYLWTGEATGQSAFAQVIADRHKILFDRNSAIKSSIVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQSKSKKNRRAGKRYKFVDAVPDIFAQIEVNEKKIRQKAQILAQKELPIDEDEEMKDLLDFADVTYEKHKNGGLIKGRFGQARMVTTTHSRAPSLSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 338 | Phosphorylation | KFVMRNGSGNWLADQ EEHHHCCCCCCHHHH | 32.28 | 21712546 | |
| 413 | Phosphorylation | LPAEINRSFLSFKSG CCHHHHHHHHHCCCC | 26.50 | 24505115 | |
| 416 | Phosphorylation | EINRSFLSFKSGKLG HHHHHHHHCCCCCCC | 28.72 | 24719451 | |
| 419 | Phosphorylation | RSFLSFKSGKLGGRA HHHHHCCCCCCCCEE | 38.87 | 25404012 | |
| 421 | Acetylation | FLSFKSGKLGGRAIY HHHCCCCCCCCEEHH | 51.56 | 24468305 | |
| 441 | Ubiquitination | NKYKDWIKGWRNFNA HCCHHHHHHHHCCCC | 48.44 | - | |
| 513 | Phosphorylation | CSSKWSKYKHDLAAS CHHHHHHCHHHHHHH | 14.19 | 26074081 | |
| 552 | Ubiquitination | YNPQLNLKNVQRNLI CCCCCCCCHHHHHHH | 54.74 | 21906983 | |
| 571 | Ubiquitination | QLLLLVDQIHLGEES HHHHHHHCCCCCCCC | 19.95 | 21906983 | |
| 617 | Phosphorylation | RDGLYKMYWMDDTGY CCCEEEEEEECCCCC | 8.07 | - | |
| 622 | Phosphorylation | KMYWMDDTGYSEKAT EEEEECCCCCCCCEE | 33.48 | - | |
| 624 | Phosphorylation | YWMDDTGYSEKATFA EEECCCCCCCCEEEE | 18.75 | - | |
| 625 | Phosphorylation | WMDDTGYSEKATFAS EECCCCCCCCEEEEE | 33.68 | - | |
| 629 | Phosphorylation | TGYSEKATFASVTYP CCCCCCEEEEEEECC | 30.70 | 22210691 | |
| 639 | Phosphorylation | SVTYPRGYPYNGTNY EEECCCCCCCCCCCC | 12.11 | 26552605 | |
| 641 | Phosphorylation | TYPRGYPYNGTNYVN ECCCCCCCCCCCCEE | 20.10 | 26552605 | |
| 642 | N-linked_Glycosylation | YPRGYPYNGTNYVNV CCCCCCCCCCCCEEE | 46.43 | UniProtKB CARBOHYD | |
| 644 | Phosphorylation | RGYPYNGTNYVNVTM CCCCCCCCCCEEEEE | 21.53 | 26552605 | |
| 646 | Phosphorylation | YPYNGTNYVNVTMHL CCCCCCCCEEEEEEE | 8.01 | 26552605 | |
| 650 | Phosphorylation | GTNYVNVTMHLRSPI CCCCEEEEEEECCCC | 8.15 | 26552605 | |
| 694 | Phosphorylation | IATSKHAYATYLWTG EEECCCEEEEEEEEC | 10.13 | 26552605 | |
| 696 | Phosphorylation | TSKHAYATYLWTGEA ECCCEEEEEEEECCC | 13.38 | 26552605 | |
| 697 | Phosphorylation | SKHAYATYLWTGEAT CCCEEEEEEEECCCC | 7.65 | 26552605 | |
| 700 | Phosphorylation | AYATYLWTGEATGQS EEEEEEEECCCCCCH | 23.66 | 26552605 | |
| 704 | Phosphorylation | YLWTGEATGQSAFAQ EEEECCCCCCHHHHH | 31.30 | 26552605 | |
| 707 | Phosphorylation | TGEATGQSAFAQVIA ECCCCCCHHHHHHHH | 27.05 | 26552605 | |
| 728 | Ubiquitination | FDRNSAIKSSIVPEV ECCCHHHHHCCCHHH | 37.56 | 21906983 | |
| 747 | Ubiquitination | AIVEQNLQHFKPVFQ HHHHHHHHHHHHHHH | 47.74 | 21906983 | |
| 786 | Phosphorylation | RFSDKRQTEEAIDRI CCCCHHHHHHHHHHH | 39.56 | 26699800 | |
| 797 | Phosphorylation | IDRIFAISQQQQQQS HHHHHHHHHHHHHHH | 20.64 | 28355574 | |
| 805 | Ubiquitination | QQQQQQSKSKKNRRA HHHHHHHHHHHHHHH | 63.05 | - | |
| 834 | Ubiquitination | AQIEVNEKKIRQKAQ HHHCCCHHHHHHHHH | 48.58 | 2190698 | |
| 853 | Ubiquitination | KELPIDEDEEMKDLL CCCCCCCCHHHHHHH | 54.10 | 21906983 | |
| 869 | Ubiquitination | FADVTYEKHKNGGLI HHHHHEEECCCCCCE | 49.84 | - | |
| 936 | Phosphorylation | LHGQRCLYAVLLIDS HCCCHHHHHHHHHHH | 9.78 | 25884760 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DSE_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DSE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DSE_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DSE_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615539 | Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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