INT9_HUMAN - dbPTM
INT9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INT9_HUMAN
UniProt AC Q9NV88
Protein Name Integrator complex subunit 9
Gene Name INTS9
Organism Homo sapiens (Human).
Sequence Length 658
Subcellular Localization Nucleus .
Protein Description Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. [PubMed: 23904267]
Protein Sequence MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKLYCLSGH
------CCEEECCCC		48.43-
4Phosphorylation----MKLYCLSGHPT
----CCEEECCCCCC		5.9426503514
18UbiquitinationTLPCNVLKFKSTTIM
CCCCCEEEECCCEEE		46.60-
18AcetylationTLPCNVLKFKSTTIM
CCCCCEEEECCCEEE		46.6026051181
21PhosphorylationCNVLKFKSTTIMLDC
CCEEEECCCEEEEEC		33.6424144214
22PhosphorylationNVLKFKSTTIMLDCG
CEEEECCCEEEEECC		22.4124144214
23PhosphorylationVLKFKSTTIMLDCGL
EEEECCCEEEEECCC		16.1024144214
33PhosphorylationLDCGLDMTSTLNFLP
EECCCCCCCCCCCCC		20.4424144214
34UbiquitinationDCGLDMTSTLNFLPL
ECCCCCCCCCCCCCC		25.0221890473
34UbiquitinationDCGLDMTSTLNFLPL
ECCCCCCCCCCCCCC		25.0221890473
34PhosphorylationDCGLDMTSTLNFLPL
ECCCCCCCCCCCCCC		25.0224144214
35PhosphorylationCGLDMTSTLNFLPLP
CCCCCCCCCCCCCCC		19.2924144214
42UbiquitinationTLNFLPLPLVQSPRL
CCCCCCCCCCCCCCH		28.6629967540
46PhosphorylationLPLPLVQSPRLSNLP
CCCCCCCCCCHHCCC		12.4224144214
58UbiquitinationNLPGWSLKDGNAFLD
CCCCCCCCCCCHHCC		59.0621890473
58UbiquitinationNLPGWSLKDGNAFLD
CCCCCCCCCCCHHCC		59.0621906983
58SumoylationNLPGWSLKDGNAFLD
CCCCCCCCCCCHHCC		59.0628112733
66UbiquitinationDGNAFLDKELKECSG
CCCHHCCHHHHHCCC		68.0729967540
133UbiquitinationTEPTVQIGRLLMEEL
CCCCHHHHHHHHHHH		9.3329967540
136UbiquitinationTVQIGRLLMEELVNF
CHHHHHHHHHHHHHH		3.8029967540
149UbiquitinationNFIERVPKAQSASLW
HHHHHCCHHHCCHHH		57.09-
157UbiquitinationAQSASLWKNKDIQRL
HHCCHHHCCCCHHHH		60.4529967540
159UbiquitinationSASLWKNKDIQRLLP
CCHHHCCCCHHHHCC		53.10-
167PhosphorylationDIQRLLPSPLKDAVE
CHHHHCCCCHHHCCH		42.7223403867
170UbiquitinationRLLPSPLKDAVEVST
HHCCCCHHHCCHHHC		47.20-
177PhosphorylationKDAVEVSTWRRCYTM
HHCCHHHCHHHCCCH		28.3224719451
330UbiquitinationSVPLYFISPVANSSL
CCCEEEECCCCCCCC		11.9229967540
333UbiquitinationLYFISPVANSSLEFS
EEEECCCCCCCCHHH		17.3629967540
348UbiquitinationQIFAEWLCHNKQSKV
HHHHHHHHCCCCCCE		3.3129967540
351UbiquitinationAEWLCHNKQSKVYLP
HHHHHCCCCCCEECC		32.0829967540
354UbiquitinationLCHNKQSKVYLPEPP
HHCCCCCCEECCCCC		32.1929967540
372UbiquitinationAELIQTNKLKHYPSI
HHHHCCCCCCCCCCC		63.4029967540
374UbiquitinationLIQTNKLKHYPSIHG
HHCCCCCCCCCCCCC		42.58-
399PhosphorylationVVFTGHPSLRFGDVV
EEEECCCCCCCCCHH		26.8824719451
414UbiquitinationHFMELWGKSSLNTVI
HHHHHHCCCCCCEEE		25.8621890473
435UbiquitinationSYLEALAPYQPLAMK
HHHHHHCCCCCCEEE		29.1921890473
435UbiquitinationSYLEALAPYQPLAMK
HHHHHHCCCCCCEEE		29.1921890473
438UbiquitinationEALAPYQPLAMKCIY
HHHCCCCCCEEEEEE		19.0821890473
438UbiquitinationEALAPYQPLAMKCIY
HHHCCCCCCEEEEEE		19.0821890473
441UbiquitinationAPYQPLAMKCIYCPI
CCCCCCEEEEEECCC		4.8529967540
459UbiquitinationLNFIQVSKLLKEVQP
CCHHHHHHHHHHHCC		60.0133845483
462UbiquitinationIQVSKLLKEVQPLHV
HHHHHHHHHHCCCEE		67.2929967540
465UbiquitinationSKLLKEVQPLHVVCP
HHHHHHHCCCEEECH		35.6121890473
486UbiquitinationPPAQSHRMDLMIDCQ
CCCCCCCCCEEEECC		3.7721890473
486UbiquitinationPPAQSHRMDLMIDCQ
CCCCCCCCCEEEECC		3.7721890473
489UbiquitinationQSHRMDLMIDCQPPA
CCCCCCEEEECCCCC		1.8021890473
489UbiquitinationQSHRMDLMIDCQPPA
CCCCCCEEEECCCCC		1.8021890473
510UbiquitinationEVLALPFKRRYEKIE
HHHCCCCHHHHHCCC		33.7429967540
539PhosphorylationKPGISLATVSAVLHT
CCCCEEEEEEEEEEC		21.93-
555UbiquitinationDNKHLLQPPPRPAQP
CCCCCCCCCCCCCCC		40.6133845483
558UbiquitinationHLLQPPPRPAQPTSG
CCCCCCCCCCCCCCC		44.9833845483
563PhosphorylationPPRPAQPTSGKKRKR
CCCCCCCCCCCCCCC		37.7230266825
564PhosphorylationPRPAQPTSGKKRKRV
CCCCCCCCCCCCCCC		56.1330266825
566AcetylationPAQPTSGKKRKRVSD
CCCCCCCCCCCCCCC		49.5325953088
569UbiquitinationPTSGKKRKRVSDDVP
CCCCCCCCCCCCCCC		67.06-
572PhosphorylationGKKRKRVSDDVPDCK
CCCCCCCCCCCCCCC		31.9325159151
576UbiquitinationKRVSDDVPDCKVLKP
CCCCCCCCCCCHHHH		48.5633845483
579UbiquitinationSDDVPDCKVLKPLLS
CCCCCCCCHHHHHHC		58.9633845483
582UbiquitinationVPDCKVLKPLLSGSI
CCCCCHHHHHHCCCC		36.29-
583UbiquitinationPDCKVLKPLLSGSIP
CCCCHHHHHHCCCCC		34.0829967540
586UbiquitinationKVLKPLLSGSIPVEQ
CHHHHHHCCCCCHHH		37.8729967540
600UbiquitinationQFVQTLEKHGFSDIK
HHHHHHHHCCCCCEE		52.7433845483
607UbiquitinationKHGFSDIKVEDTAKG
HCCCCCEEEEECCCC		44.5629967540
626UbiquitinationLQEAETLIQIEEDST
EEECEEEEEECCCCC		5.1821890473
629UbiquitinationAETLIQIEEDSTHII
CEEEEEECCCCCEEE		39.1021890473
629UbiquitinationAETLIQIEEDSTHII
CEEEEEECCCCCEEE		39.1021890473
632UbiquitinationLIQIEEDSTHIICDN
EEEECCCCCEEEECC		25.7621890473
632UbiquitinationLIQIEEDSTHIICDN
EEEECCCCCEEEECC		25.7621890473
647UbiquitinationDEMLRVRLRDLVLKF
HHHHHHHHHHHHHHH		4.5821890473
650UbiquitinationLRVRLRDLVLKFLQK
HHHHHHHHHHHHHHH		3.8221890473
653UbiquitinationRLRDLVLKFLQKF--
HHHHHHHHHHHHC--		36.2321890473
671Ubiquitination--------------------
--------------------		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INT9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INT9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INT9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
INT11_HUMANCPSF3Lphysical
26344197
INT5_HUMANINTS5physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INT9_HUMAN

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Related Literatures of Post-Translational Modification

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