NARF_HUMAN - dbPTM
NARF_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NARF_HUMAN
UniProt AC Q9UHQ1
Protein Name Nuclear prelamin A recognition factor
Gene Name NARF
Organism Homo sapiens (Human).
Sequence Length 456
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKGEFHKLADAKIFLSDCLACDSCMTAEEGVQLSQQNAKDFFRVLNLNKKCDTSKHKVLVVSVCPQSLPYFAAKFNLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRYRQHSEEERTLPMLTSACPGWVRYAERVLGRPITAHLCTAKSPQQVMGSLVKDYFARQQNLSPEKIFHVIVAPCYDKKLEALQESLPPALHGSRGADCVLTSGEIAQIMEQGDLSVRDAAVDTLFGDLKEDKVTRHDGASSDGHLAHIFRHAAKELFNEDVEEVTYRALRNKDFQEVTLEKNGEVVLRFAAAYGFRNIQNMILKLKKGKFPFHFVEVLACAGGCLNGRGQAQTPDGHADKALLRQMEGIYADIPVRRPESSAHVQELYQEWLEGINSPKAREVLHTTYQSQERGTHSLDIKW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MKCEHCTRK
------CCCCCCCHH		48.6125953088
24PhosphorylationTDDQENVSADAPSPA
CCCCCCCCCCCCCCC		31.8226074081
25UbiquitinationDDQENVSADAPSPAQ
CCCCCCCCCCCCCCH		16.8329967540
29PhosphorylationNVSADAPSPAQENGE
CCCCCCCCCCHHCCC		34.2925159151
37UbiquitinationPAQENGEKGEFHKLA
CCHHCCCCCCCCHHH		66.2029967540
42UbiquitinationGEKGEFHKLADAKIF
CCCCCCCHHHCCEEH		51.1729967540
83UbiquitinationFFRVLNLNKKCDTSK
HHHHHCCCCCCCCCC		40.4422817900
84UbiquitinationFRVLNLNKKCDTSKH
HHHHCCCCCCCCCCC		58.9229967540
86UbiquitinationVLNLNKKCDTSKHKV
HHCCCCCCCCCCCCE		8.0322817900
102PhosphorylationVVSVCPQSLPYFAAK
EEEECCCCCHHHHHH		19.22-
105PhosphorylationVCPQSLPYFAAKFNL
ECCCCCHHHHHHCCC		15.90-
112UbiquitinationYFAAKFNLSVTDASR
HHHHHCCCCHHHHHH		4.9822817900
115UbiquitinationAKFNLSVTDASRRLC
HHCCCCHHHHHHHHH		23.6022817900
127PhosphorylationRLCGFLKSLGVHYVF
HHHHHHHHCCCEEEE		32.2824719451
137PhosphorylationVHYVFDTTIAADFSI
CEEEEECHHHHCHHH		15.5124719451
147UbiquitinationADFSILESQKEFVRR
HCHHHHHHHHHHHHH		43.0132015554
158UbiquitinationFVRRYRQHSEEERTL
HHHHHHHCCHHHHCH		28.3332015554
173UbiquitinationPMLTSACPGWVRYAE
HHHHHCCHHHHHHHH		39.1229967540
184UbiquitinationRYAERVLGRPITAHL
HHHHHHHCCCEEEEE		30.3829967540
195UbiquitinationTAHLCTAKSPQQVMG
EEEECCCCCHHHHHH		44.51-
196PhosphorylationAHLCTAKSPQQVMGS
EEECCCCCHHHHHHH		26.0225159151
206UbiquitinationQVMGSLVKDYFARQQ
HHHHHHHHHHHHHHC		52.5932015554
216PhosphorylationFARQQNLSPEKIFHV
HHHHCCCCHHHEEEE		38.2628674419
219UbiquitinationQQNLSPEKIFHVIVA
HCCCCHHHEEEEEEE		54.80-
224UbiquitinationPEKIFHVIVAPCYDK
HHHEEEEEEEECCHH		1.3229967540
227UbiquitinationIFHVIVAPCYDKKLE
EEEEEEEECCHHHHH		13.3022817900
231AcetylationIVAPCYDKKLEALQE
EEEECCHHHHHHHHH		32.5523749302
232UbiquitinationVAPCYDKKLEALQES
EEECCHHHHHHHHHH		48.9729967540
235UbiquitinationCYDKKLEALQESLPP
CCHHHHHHHHHHCCH		25.6129967540
235 (in isoform 3)Ubiquitination-25.6121906983
238UbiquitinationKKLEALQESLPPALH
HHHHHHHHHCCHHHC		55.9129967540
241UbiquitinationEALQESLPPALHGSR
HHHHHHCCHHHCCCC		22.7722817900
249UbiquitinationPALHGSRGADCVLTS
HHHCCCCCCCEEEEC		27.7129967540
260UbiquitinationVLTSGEIAQIMEQGD
EEECHHHHHHHHHCC		6.6429967540
278 (in isoform 3)Ubiquitination-3.8021906983
283UbiquitinationDTLFGDLKEDKVTRH
HHHHCCCCCCCCCCC		69.4822817900
283 (in isoform 1)Ubiquitination-69.4821906983
286UbiquitinationFGDLKEDKVTRHDGA
HCCCCCCCCCCCCCC		46.7422817900
308UbiquitinationHIFRHAAKELFNEDV
HHHHHHHHHHCCCCH		56.5929967540
326 (in isoform 1)Ubiquitination-54.1821906983
326UbiquitinationTYRALRNKDFQEVTL
HHHHHHCCCCCEEEE		54.18-
329UbiquitinationALRNKDFQEVTLEKN
HHHCCCCCEEEEEEC		55.1529967540
330 (in isoform 2)Ubiquitination-37.1521906983
332UbiquitinationNKDFQEVTLEKNGEV
CCCCCEEEEEECCEE		28.5722817900
335UbiquitinationFQEVTLEKNGEVVLR
CCEEEEEECCEEEHH		73.6629967540
346UbiquitinationVVLRFAAAYGFRNIQ
EEHHHHHHHCCHHHH		11.1029967540
354UbiquitinationYGFRNIQNMILKLKK
HCCHHHHHHHHHHHC		18.7029967540
358AcetylationNIQNMILKLKKGKFP
HHHHHHHHHHCCCCC		47.5430590663
373 (in isoform 2)Ubiquitination-6.0621906983
387PhosphorylationNGRGQAQTPDGHADK
CCCCCCCCCCCHHHH		26.7728985074
394UbiquitinationTPDGHADKALLRQME
CCCCHHHHHHHHHHH		41.5429967540
404PhosphorylationLRQMEGIYADIPVRR
HHHHHCCCCCCCCCC		14.7428796482
422PhosphorylationSAHVQELYQEWLEGI
HHHHHHHHHHHHHCC		12.0228796482
431PhosphorylationEWLEGINSPKAREVL
HHHHCCCCHHHHHHH		26.3429523821
440PhosphorylationKAREVLHTTYQSQER
HHHHHHHHHHCCCCC		24.0429523821
440UbiquitinationKAREVLHTTYQSQER
HHHHHHHHHHCCCCC		24.0429967540
441PhosphorylationAREVLHTTYQSQERG
HHHHHHHHHCCCCCC		14.6029523821
442PhosphorylationREVLHTTYQSQERGT
HHHHHHHHCCCCCCC		13.8129523821
444PhosphorylationVLHTTYQSQERGTHS
HHHHHHCCCCCCCCC		24.4817525332
449PhosphorylationYQSQERGTHSLDIKW
HCCCCCCCCCCCCCC		17.9522210691
450PhosphorylationQSQERGTHSLDIKW-
CCCCCCCCCCCCCC-		29.2325147952
451PhosphorylationSQERGTHSLDIKW--
CCCCCCCCCCCCC--		27.8128450419
477Phosphorylation----------------------------
----------------------------		24719451
497Phosphorylation------------------------------------------------
------------------------------------------------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NARF_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NARF_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NARF_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LMNA_HUMANLMNAphysical
10514485
A4_HUMANAPPphysical
21832049
LEF1_HUMANLEF1physical
24394665
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NARF_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-444, AND MASSSPECTROMETRY.

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