KLF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF5_HUMAN
• UniProt AC: Q13887
• Protein Name: Krueppel-like factor 5
• Gene Name: KLF5
• Organism: Homo sapiens (Human).
• Sequence Length: 457
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes..
• Protein Sequence: MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Ubiquitination	LGPVPQPPAPQDEPV CCCCCCCCCCCCCCC	51.85	-
31	Sumoylation	EPVFAQLKPVLGAAN CCCHHHHHHHHCCCC	22.47	28112733
31	Acetylation	EPVFAQLKPVLGAAN CCCHHHHHHHHCCCC	22.47	26051181
31	Ubiquitination	EPVFAQLKPVLGAAN CCCHHHHHHHHCCCC	22.47	2190698
52	Sumoylation	LFPGEELKHAHHRPQ CCCHHHHHCCCCCCC	41.86	28112733
52	Ubiquitination	LFPGEELKHAHHRPQ CCCHHHHHCCCCCCC	41.86	-
94	Sumoylation	QTRCEMEKYLTPQLP HHHHHHHHHCCCCCC	44.22	28112733
95	Phosphorylation	TRCEMEKYLTPQLPP HHHHHHHHCCCCCCC	11.51	27642862
110	Sumoylation	VPIIPEHKKYRRDSA CCCCCCCCCCCCCCC	50.25	28112733
110	Ubiquitination	VPIIPEHKKYRRDSA CCCCCCCCCCCCCCC	50.25	-
110	Sumoylation	VPIIPEHKKYRRDSA CCCCCCCCCCCCCCC	50.25	-
116	Phosphorylation	HKKYRRDSASVVDQF CCCCCCCCCHHHHHH	22.19	27422710
153	Phosphorylation	LRTGLYKSQRPCVTH HHCCCCCCCCCCEEE	20.19	22817900
159	O-linked_Glycosylation	KSQRPCVTHIKTEPV CCCCCCEEEECCCCE	25.30	30059200
162	Sumoylation	RPCVTHIKTEPVAIF CCCEEEECCCCEEEE	38.95	-
162	Sumoylation	RPCVTHIKTEPVAIF CCCEEEECCCCEEEE	38.95	-
209	Sumoylation	EVNNIFIKQELPTPD HHCCEEEECCCCCCC	27.28	-
209	Sumoylation	EVNNIFIKQELPTPD HHCCEEEECCCCCCC	27.28	-
278	Acetylation	PQTAVKQFQGMPPCT CHHHHHHHCCCCCCC	5.85	14612398
303	Phosphorylation	QATYFPPSPPSSEPG CCCCCCCCCCCCCCC	50.08	26657352
323	Phosphorylation	AEMLQNLTPPPSYAA HHHHHHCCCCHHHHH	41.10	26657352
335	Acetylation	YAATIASKLAIHNPN HHHHHHHHHHHCCCC	32.68	26051181
346	Phosphorylation	HNPNLPTTLPVNSQN CCCCCCCCCCCCCCC	27.42	-
359	Phosphorylation	QNIQPVRYNRRSNPD CCCCCCCCCCCCCCC	17.16	24719451
363	Phosphorylation	PVRYNRRSNPDLEKR CCCCCCCCCCCHHHC	49.86	26657352
369	Acetylation	RSNPDLEKRRIHYCD CCCCCHHHCCEEECC	55.03	17283079
377	Phosphorylation	RRIHYCDYPGCTKVY CCEEECCCCCCCEEE	9.66	28152594
381	Phosphorylation	YCDYPGCTKVYTKSS ECCCCCCCEEEECCH	29.47	28152594
391	Ubiquitination	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
391	Sumoylation	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
391	Sumoylation	YTKSSHLKAHLRTHT EECCHHHHHHHHHCC	28.47	-
396	Phosphorylation	HLKAHLRTHTGEKPY HHHHHHHHCCCCCCE	30.10	28348404
398	Phosphorylation	KAHLRTHTGEKPYKC HHHHHHCCCCCCEEE	46.56	26270265
401	Ubiquitination	LRTHTGEKPYKCTWE HHHCCCCCCEEECCC	55.80	-
428	Phosphorylation	TRHYRKHTGAKPFQC HHHHHHHCCCCCEEC	41.70	29214152
441	Phosphorylation	QCGVCNRSFSRSDHL ECCCCCCCCCHHHHH	17.37	29496963
443	Phosphorylation	GVCNRSFSRSDHLAL CCCCCCCCHHHHHHH	31.92	20068231
445	Phosphorylation	CNRSFSRSDHLALHM CCCCCCHHHHHHHHH	28.34	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
153	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
303	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:20484041
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:16223724
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM25	Q14258	PMID:21542805
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF2	Q9HAU4	PMID:21953463

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SET_HUMAN	SET	physical	14612398
EP300_HUMAN	EP300	physical	14612398
CBP_HUMAN	CREBBP	physical	12682370
ESR1_HUMAN	ESR1	physical	19569049
HDAC1_HUMAN	HDAC1	physical	15668237
EP300_HUMAN	EP300	physical	15668237
FBXW7_HUMAN	FBXW7	physical	20388706
GSK3B_HUMAN	GSK3B	physical	20388706
HDAC2_HUMAN	HDAC2	physical	21383775
RARA_HUMAN	RARA	physical	21383775
ESR2_HUMAN	ESR2	physical	21487105
SMUF2_HUMAN	SMURF2	physical	21953463
FBXW7_HUMAN	FBXW7	physical	20484041
WWTR1_HUMAN	WWTR1	physical	22045023
WWP1_HUMAN	WWP1	physical	22045023
TRI25_HUMAN	TRIM25	physical	22452784
YAP1_HUMAN	YAP1	physical	22632819
RRBP1_HUMAN	RRBP1	physical	22939629
SMAD4_HUMAN	SMAD4	physical	19419955
SMAD2_HUMAN	SMAD2	physical	19419955
SMAD3_HUMAN	SMAD3	physical	19419955
EP300_HUMAN	EP300	physical	19419955
FBXW7_HUMAN	FBXW7	physical	24398687
CTNB1_HUMAN	CTNNB1	physical	19435907
SRBP1_HUMAN	SREBF1	physical	18774944
NCOR1_HUMAN	NCOR1	physical	18500350
NCOR2_HUMAN	NCOR2	physical	18500350
PPARG_HUMAN	PPARG	physical	18500350
CBP_HUMAN	CREBBP	physical	18500350
AN32B_HUMAN	ANP32B	physical	18039846
PARP1_HUMAN	PARP1	physical	17283079
P53_HUMAN	TP53	physical	16595680
ATX3L_HUMAN	ATXN3L	physical	26079537
RXRA_HUMAN	RXRA	physical	16224062
RARA_HUMAN	RARA	physical	16224062
CEBPB_HUMAN	CEBPB	physical	16054042
CEBPG_HUMAN	CEBPG	physical	16054042
CEBPA_HUMAN	CEBPA	physical	21821915
JUN_HUMAN	JUN	physical	19628677
BAP1_HUMAN	BAP1	physical	26419610
HCFC1_HUMAN	HCFC1	physical	26419610
OGT1_HUMAN	OGT	physical	26419610
ACTA_HUMAN	ACTA2	physical	29074464
FBXW7_HUMAN	FBXW7	physical	29074464

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.