ATX3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATX3L_HUMAN
• UniProt AC: Q9H3M9
• Protein Name: Ataxin-3-like protein {ECO:0000305}
• Gene Name: ATXN3L {ECO:0000312|HGNC:HGNC:24173}
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Nucleus.
• Protein Description: Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro)..
• Protein Sequence: MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	NYKQHWFTIRKFGKH CCCCEEEEEEECCCC	18.06	24719451
182	Phosphorylation	DQLLQIISVEEMDTP HHHHEEEEHHHCCCC	25.71	30622161
188	Phosphorylation	ISVEEMDTPKLNGKK EEHHHCCCCCCCCCH	22.48	30622161
249	Phosphorylation	REDEHLRSTIELSMQ CCCHHHHHHHHHHCC	39.85	25693802
250	Phosphorylation	EDEHLRSTIELSMQG CCHHHHHHHHHHCCC	16.43	25693802
254	Phosphorylation	LRSTIELSMQGSSGN HHHHHHHHCCCCCCC	9.03	25693802
258	Phosphorylation	IELSMQGSSGNTSQD HHHHCCCCCCCCCCC	20.41	25693802
259	Phosphorylation	ELSMQGSSGNTSQDL HHHCCCCCCCCCCCC	42.77	25693802
262	Phosphorylation	MQGSSGNTSQDLPKT CCCCCCCCCCCCCCC	31.15	25693802
263	Phosphorylation	QGSSGNTSQDLPKTS CCCCCCCCCCCCCCC	26.20	25693802
316	Phosphorylation	YLHERPTTSSRAIES HHCCCCCCCCHHHHC	27.64	-
326	Phosphorylation	RAIESDLSDDISEGT HHHHCCCCCCCCHHH	37.92	22210691
330	Phosphorylation	SDLSDDISEGTVQAA CCCCCCCCHHHHHHH	36.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATX3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATX3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATX3L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	21118805
KLF5_HUMAN	KLF5	physical	26079537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.