| UniProt ID | ESR2_HUMAN | |
|---|---|---|
| UniProt AC | Q92731 | |
| Protein Name | Estrogen receptor beta | |
| Gene Name | ESR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 530 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. [PubMed: 20074560 Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.] | |
| Protein Sequence | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Sumoylation | ----MDIKNSPSSLN ----CCCCCCHHHCC | 47.29 | - | |
| 36 | Phosphorylation | SIYIPSSYVDSHHEY CEECCHHHCCCCCCC | 16.77 | - | |
| 56 | Phosphorylation | YSPAVMNYSIPSNVT ECCCCCCCCCCCCCC | 7.00 | 22817900 | |
| 87 | Phosphorylation | WPTPGHLSPLVVHRQ CCCCCCCCHHHHHHH | 15.54 | 22817900 | |
| 105 | Phosphorylation | LYAEPQKSPWCEARS HHCCCCCCCCHHHCC | 20.56 | 9636657 | |
| 135 | Phosphorylation | VSGNRCASPVTGPGS HCCCCCCCCCCCCCC | 24.43 | - | |
| 165 | Phosphorylation | GYHYGVWSCEGCKAF CCCCEEEECCHHHHH | 10.41 | 9528769 | |
| 176 | Phosphorylation | CKAFFKRSIQGHNDY HHHHHHHHHCCCCCC | 21.61 | 22266331 | |
| 200 | Phosphorylation | IDKNRRKSCQACRLR ECCCHHHCCHHHCCC | 15.06 | 22266331 | |
| 210 | Phosphorylation | ACRLRKCYEVGMVKC HHCCCCCEEECCEEC | 19.38 | 24719451 | |
| 320 (in isoform 7) | Phosphorylation | - | 10.04 | 26503514 | |
| 323 | Phosphorylation | IPGFVELSLFDQVRL CCCEEEECHHHHHHH | 17.31 | 23403867 | |
| 324 (in isoform 7) | Phosphorylation | - | 9.54 | 26503514 | |
| 331 (in isoform 7) | Phosphorylation | - | 2.97 | 26503514 | |
| 415 | Phosphorylation | SSMYPLVTATQDADS CCCCCCHHCCCCCCH | 31.50 | 30206219 | |
| 417 | Phosphorylation | MYPLVTATQDADSSR CCCCHHCCCCCCHHH | 20.02 | 30206219 | |
| 422 | Phosphorylation | TATQDADSSRKLAHL HCCCCCCHHHHHHHH | 33.49 | 24719451 | |
| 423 | Phosphorylation | ATQDADSSRKLAHLL CCCCCCHHHHHHHHH | 33.70 | 30206219 | |
| 463 | Phosphorylation | ANLLMLLSHVRHASN HHHHHHHHHHHHHHH | 18.90 | - | |
| 469 | Phosphorylation | LSHVRHASNKGMEHL HHHHHHHHHHHHHHH | 32.71 | - | |
| 484 (in isoform 4) | Phosphorylation | - | 2.92 | 22210691 | |
| 488 | Phosphorylation | CKNVVPVYDLLLEML CCCCCCHHHHHHHHH | 8.53 | - | |
| 491 (in isoform 4) | Phosphorylation | - | 3.30 | 22210691 | |
| 492 (in isoform 2) | Phosphorylation | - | 4.77 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 36 | Y | Phosphorylation | Kinase | ABL1 | P00519 | GPS |
| 165 | S | Phosphorylation | Kinase | RPS6KA1 | Q15418 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:16940184 |
| - | K | Ubiquitination | E3 ubiquitin ligase | MDM2 | Q00987 | PMID:22349818 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ESR2_HUMAN !! | ||||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00255 | Diethylstilbestrol |
| DB00783 | Estradiol |
| DB01196 | Estramustine |
| DB04573 | Estriol |
| DB04574 | Estropipate |
| DB00481 | Raloxifene |
| DB00675 | Tamoxifen |
| DB01108 | Trilostane |
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