CASZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASZ1_HUMAN
• UniProt AC: Q86V15
• Protein Name: Zinc finger protein castor homolog 1
• Gene Name: CASZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 1759
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator. [PubMed: 23639441]
• Protein Sequence: MDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAAGLGLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAEAAGAGARTPALAALAALGAPGPAPTAASSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDLGTAEGTRCT ---CCCCCCCCCCCC	28.91	21406692
9	Phosphorylation	DLGTAEGTRCTDPPA CCCCCCCCCCCCCCC	17.68	21406692
12	Phosphorylation	TAEGTRCTDPPAGKP CCCCCCCCCCCCCCC	48.53	21406692
39	Phosphorylation	NAICAKLSRQVVVEK HHHHHHHHCCEEEEE	21.69	22210691
52	Phosphorylation	EKRADAGSHTEGSPS EEECCCCCCCCCCCC	29.02	23312004
54	Phosphorylation	RADAGSHTEGSPSQP ECCCCCCCCCCCCCC	43.68	22985185
57	Phosphorylation	AGSHTEGSPSQPRDQ CCCCCCCCCCCCCCC	18.36	25159151
59	Phosphorylation	SHTEGSPSQPRDQER CCCCCCCCCCCCCHH	55.29	25159151
122	Phosphorylation	ELPPEGVYMVQPQGC CCCCCCEEEECCCCC	11.48	27251275
130	Phosphorylation	MVQPQGCSDEEDHAE EECCCCCCCCCCCCC	55.68	25849741
140	Phosphorylation	EDHAEEPSKDGGALE CCCCCCCCCCCCCCC	46.81	27251275
151	Phosphorylation	GALEEKDSDGAASKE CCCCCCCCCCCCCCC	49.35	26657352
156	Phosphorylation	KDSDGAASKEDSGPS CCCCCCCCCCCCCCC	35.72	27362937
168	Phosphorylation	GPSTRQASGEASSLR CCCHHHCCCCCHHHH	28.91	28348404
183	Phosphorylation	DYAASTMTEFLGMFG HHHHHHHHHHHHHHC	24.55	-
205	Phosphorylation	DELARKISFEKLHAG HHHHHHHCHHHHCCC	30.32	29496963
213	Phosphorylation	FEKLHAGSTPEAATS HHHHCCCCCCHHHHH	41.39	25159151
214	Phosphorylation	EKLHAGSTPEAATSS HHHCCCCCCHHHHHC	25.00	30576142
219	Phosphorylation	GSTPEAATSSMLPTS CCCCHHHHHCCCCCC	28.51	20068231
220	Phosphorylation	STPEAATSSMLPTSE CCCHHHHHCCCCCCH	14.71	20068231
220 (in isoform 2)	Phosphorylation	-	14.71	-
221	Phosphorylation	TPEAATSSMLPTSED CCHHHHHCCCCCCHH	21.71	20068231
225	Phosphorylation	ATSSMLPTSEDTLSK HHHCCCCCCHHHHHH	40.56	28985074
226	Phosphorylation	TSSMLPTSEDTLSKR HHCCCCCCHHHHHHH	31.38	20068231
229	Phosphorylation	MLPTSEDTLSKRARF CCCCCHHHHHHHHHH	28.95	28985074
231	Phosphorylation	PTSEDTLSKRARFSK CCCHHHHHHHHHHHH	23.37	20068231
239	Phosphorylation	KRARFSKYEEYIRKL HHHHHHHHHHHHHHH	16.88	-
253	Phosphorylation	LKAGEQLSWPAPSTK HHCCCCCCCCCCCCC	30.61	-
261	Phosphorylation	WPAPSTKTEERVGKE CCCCCCCCCHHHCCH	43.07	25022875
272	Phosphorylation	VGKEVVGTLPGLRLP HCCHHHCCCCCCCCC	20.40	25022875
277	Methylation	VGTLPGLRLPSSTAH HCCCCCCCCCCCCCC	50.93	-
288	Sumoylation	STAHLETKATILPLP CCCCCEECEEEEECC	33.87	28112733
288	Ubiquitination	STAHLETKATILPLP CCCCCEECEEEEECC	33.87	-
290	Phosphorylation	AHLETKATILPLPSH CCCEECEEEEECCCC	25.30	30243723
296	Phosphorylation	ATILPLPSHSSVQMQ EEEEECCCCCHHHHH	43.62	30243723
337	Phosphorylation	GSTYKKPSKYDLENV CCCCCCCCCCCCCCC	53.37	-
345	Acetylation	KYDLENVKYLHLFKP CCCCCCCEEEEEECC	54.39	26051181
346	Phosphorylation	YDLENVKYLHLFKPG CCCCCCEEEEEECCC	8.62	-
351	Acetylation	VKYLHLFKPGEGSPD CEEEEEECCCCCCCC	59.48	26051181
356	Phosphorylation	LFKPGEGSPDMGGAI EECCCCCCCCCCCEE	17.27	25159151
402	Phosphorylation	LAPAPLASVPSAPSA CCCCCCCCCCCCCCC	42.09	26356563
405	Phosphorylation	APLASVPSAPSAPGP CCCCCCCCCCCCCCC	51.13	26356563
408	Phosphorylation	ASVPSAPSAPGPGPE CCCCCCCCCCCCCCC	46.97	26356563
419	Phosphorylation	PGPEPPASLSFNTPE CCCCCCCCCCCCCHH	30.25	26356563
421	Phosphorylation	PEPPASLSFNTPEYL CCCCCCCCCCCHHHH	17.60	26356563
424	Phosphorylation	PASLSFNTPEYLKST CCCCCCCCHHHHHHH	18.58	26356563
440	Phosphorylation	SKTDSITTGTVSTVK CCCCCCCCCCCCCCC	29.23	-
490	Phosphorylation	AYQYREHYHCLDPEC EHHHHCHHCCCCCCC	6.89	30576142
521	Phosphorylation	MHKKRDNSLQHGFMR CCCCCCCCCCCCCCC	33.42	28348404
570	Phosphorylation	TSTSDVMTHENFHKK ECHHHHHCCCCHHHH	26.36	-
633	Phosphorylation	DIEKHKSYHIKDDAY CHHHCCCCCCCCCHH	16.62	-
649	Phosphorylation	KDGFKKFYKYEECKY CCCHHHCEEHHHCCC	22.88	-
651	Phosphorylation	GFKKFYKYEECKYEG CHHHCEEHHHCCCCC	12.94	-
661	Phosphorylation	CKYEGCVYSKATNHF CCCCCCEEECCCCCE	14.45	-
699	Phosphorylation	HERRHIRSSGALGLP HHHHHHHHCCCCCCC	32.30	28348404
700	Phosphorylation	ERRHIRSSGALGLPP HHHHHHHCCCCCCCH	20.45	28348404
708	Phosphorylation	GALGLPPSLLGAKDT CCCCCCHHHCCCCCC	34.00	25921289
715	Phosphorylation	SLLGAKDTEHEESSN HHCCCCCCCCCCCCC	38.24	30278072
720	Phosphorylation	KDTEHEESSNDDLVD CCCCCCCCCCCCCCC	31.30	30266825
721	Phosphorylation	DTEHEESSNDDLVDF CCCCCCCCCCCCCCH	47.78	30266825
729	Phosphorylation	NDDLVDFSALSSKNS CCCCCCHHHHCCCCC	24.68	27251275
732	Phosphorylation	LVDFSALSSKNSSLS CCCHHHHCCCCCCCC	38.70	27251275
733	Phosphorylation	VDFSALSSKNSSLSA CCHHHHCCCCCCCCC	36.38	27251275
736	Phosphorylation	SALSSKNSSLSASPT HHHCCCCCCCCCCCC	36.07	30278072
737	Phosphorylation	ALSSKNSSLSASPTS HHCCCCCCCCCCCCC	35.42	30278072
739	Phosphorylation	SSKNSSLSASPTSQQ CCCCCCCCCCCCCHH	28.75	30278072
741	Phosphorylation	KNSSLSASPTSQQSS CCCCCCCCCCCHHHH	25.90	25849741
743	Phosphorylation	SSLSASPTSQQSSAS CCCCCCCCCHHHHHH	36.35	30278072
744	Phosphorylation	SLSASPTSQQSSASL CCCCCCCCHHHHHHH	29.61	30278072
747	Phosphorylation	ASPTSQQSSASLAAA CCCCCHHHHHHHHHH	21.89	26074081
748	Phosphorylation	SPTSQQSSASLAAAT CCCCHHHHHHHHHHH	19.96	30278072
750	Phosphorylation	TSQQSSASLAAATAA CCHHHHHHHHHHHHH	22.08	26074081
755	Phosphorylation	SASLAAATAATEAGP HHHHHHHHHHHHCCC	16.46	26074081
758	Phosphorylation	LAAATAATEAGPSAT HHHHHHHHHCCCCCC	24.73	26074081
763	Phosphorylation	AATEAGPSATKPPNS HHHHCCCCCCCCCCC	47.88	26074081
765	Phosphorylation	TEAGPSATKPPNSKI HHCCCCCCCCCCCCC	48.71	26074081
770	Phosphorylation	SATKPPNSKISGLLP CCCCCCCCCCCCCCC	36.82	26074081
797	Phosphorylation	LSNSGLPTPTPYFPI HHCCCCCCCCCCCCC	44.85	24719451
867	Phosphorylation	ASIMERISASKGLIS HHHHHHHHCCCCCHH	32.48	21406692
869	Phosphorylation	IMERISASKGLISPM HHHHHHCCCCCHHHH	22.07	24719451
874	Phosphorylation	SASKGLISPMMARLA HCCCCCHHHHHHHHH	16.28	20068231
874 (in isoform 2)	Phosphorylation	-	16.28	-
886	Acetylation	RLAAAALKPSATFDP HHHHHHHCCCCEECC	32.00	26051181
888	Phosphorylation	AAAALKPSATFDPGS HHHHHCCCCEECCCC	38.05	-
962	Phosphorylation	SSLMNKMSQGNPGLG HHHHHHHHCCCCCHH	36.22	30576742
970	Phosphorylation	QGNPGLGSLLNIKAE CCCCCHHHHHHHHEE	34.42	27251275
975	Sumoylation	LGSLLNIKAEAEGSP HHHHHHHHEECCCCC	38.82	28112733
981	Phosphorylation	IKAEAEGSPAAEPSP HHEECCCCCCCCCCH	11.67	25159151
981 (in isoform 2)	Phosphorylation	-	11.67	-
987	Phosphorylation	GSPAAEPSPFLGKAV CCCCCCCCHHHHHHH	21.57	25159151
1085	Phosphorylation	TKPPMAPSSPPVPPV CCCCCCCCCCCCCCC	46.03	28348404
1086	Phosphorylation	KPPMAPSSPPVPPVT CCCCCCCCCCCCCCC	31.97	28348404
1093	Phosphorylation	SPPVPPVTTATVSSL CCCCCCCCEEEECCC	19.25	28348404
1094	Phosphorylation	PPVPPVTTATVSSLE CCCCCCCEEEECCCC	22.14	28348404
1096	Phosphorylation	VPPVTTATVSSLEGP CCCCCEEEECCCCCC	20.87	28348404
1098	Phosphorylation	PVTTATVSSLEGPAP CCCEEEECCCCCCCC	25.50	28348404
1099	Phosphorylation	VTTATVSSLEGPAPS CCEEEECCCCCCCCC	26.55	28348404
1142	Phosphorylation	SVPHLPASPLATTSL CCCCCCCCCCCCCCC	20.64	28348404
1146	Phosphorylation	LPASPLATTSLENAK CCCCCCCCCCCHHCC	25.30	27251275
1195	Phosphorylation	NCKYVCKTSGKAESH CCCEEECCCCCHHHH	37.27	30631047
1196	Phosphorylation	CKYVCKTSGKAESHC CCEEECCCCCHHHHH	24.64	30631047
1374	Phosphorylation	ESSTMDRSCSSTPVG CCCCCCCCCCCCCCC	17.68	28348404
1376	Phosphorylation	STMDRSCSSTPVGNE CCCCCCCCCCCCCCC	38.19	28348404
1377	Phosphorylation	TMDRSCSSTPVGNES CCCCCCCCCCCCCCC	40.85	28348404
1378	Phosphorylation	MDRSCSSTPVGNEST CCCCCCCCCCCCCCC	13.00	24719451
1410	Phosphorylation	FWIIEDMSPFGKRRK EEEEECCCCCCCCCC	29.42	22617229
1423	Methylation	RKTASSRKMLDEGMM CCCHHHHHHHCCCCC	45.84	-
1472	O-linked_Glycosylation	GYKFCGRTHMYKHAQ CCEECCCCHHHHHCC	9.04	30379171
1493	Acetylation	NLVLDDFKRFKASLS CEEHHHHHHHHHHEE	65.01	15608283
1525	Phosphorylation	LRCRFRCTDSTKVTA EEEEEEECCCCCCEE	28.82	-
1527	Phosphorylation	CRFRCTDSTKVTAHR EEEEECCCCCCEEEH	16.39	-
1528	Phosphorylation	RFRCTDSTKVTAHRK EEEECCCCCCEEEHH	32.13	-
1531	Phosphorylation	CTDSTKVTAHRKHHG ECCCCCCEEEHHHCC	20.50	-
1717	Phosphorylation	DDDEDLRTDSEESLP CCCHHHHCCCHHHHH	51.69	23403867
1719	Phosphorylation	DEDLRTDSEESLPEA CHHHHCCCHHHHHHH	42.52	23403867
1722	Phosphorylation	LRTDSEESLPEAAAE HHCCCHHHHHHHHHH	45.21	23403867
1737	Phosphorylation	AAGAGARTPALAALA HCCCCCCHHHHHHHH	16.63	28176443
1754	Phosphorylation	GAPGPAPTAASSP-- CCCCCCCCCCCCC--	36.64	30266825
1757	Phosphorylation	GPAPTAASSP----- CCCCCCCCCC-----	40.45	30266825
1758	Phosphorylation	PAPTAASSP------ CCCCCCCCC------	29.87	26503892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.