PNRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNRC1_HUMAN
• UniProt AC: Q12796
• Protein Name: Proline-rich nuclear receptor coactivator 1
• Gene Name: PNRC1
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor coactivator. May play a role in signal transduction..
• Protein Sequence: MTVVSVPQREPLVLGGRLAPLGFSSRGYFGALPMVTTAPPPLPRIPDPRALPPTLFLPHFLGGDGPCLTPQPRAPAALPNRSLAVAGGTPRAAPKKRRKKKVRASPAGQLPSRFHQYQQHRPSLEGGRSPATGPSGAQEVPGPAAALAPSPAAAAGTEGASPDLAPLRPAAPGQTPLRKEVLKSKMGKSEKIALPHGQLVHGIHLYEQPKINRQKSKYNLPLTKITSAKRNENNFWQDSVSSDRIQKQEKKPFKNTENIKNSHLKKSAFLTEVSQKENYAGAKFSDPPSPSVLPKPPSHWMGSTVENSNQNRELMAVHLKTLLKVQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVVSVPQR ------CCEECCCCC	29.61	24043423
5	Phosphorylation	---MTVVSVPQREPL ---CCEECCCCCCCE	24.60	24043423
24	Phosphorylation	RLAPLGFSSRGYFGA EECCCCCCCCCCCCC	19.82	24043423
25	Phosphorylation	LAPLGFSSRGYFGAL ECCCCCCCCCCCCCC	27.71	24043423
28	Phosphorylation	LGFSSRGYFGALPMV CCCCCCCCCCCCCEE	9.57	-
36	Phosphorylation	FGALPMVTTAPPPLP CCCCCEECCCCCCCC	15.81	-
37	Phosphorylation	GALPMVTTAPPPLPR CCCCEECCCCCCCCC	26.25	-
89	Phosphorylation	SLAVAGGTPRAAPKK CEECCCCCCCCCCHH	14.53	26329039
105	Phosphorylation	RKKKVRASPAGQLPS HCCCCCCCCCCCCCH	12.52	28555341
123	Phosphorylation	QYQQHRPSLEGGRSP HHHHHCCCCCCCCCC	38.72	26091039
206	Phosphorylation	LVHGIHLYEQPKINR EECEEEEECCCCCCC	9.80	27642862
218	Phosphorylation	INRQKSKYNLPLTKI CCCCHHHCCCCCHHH	29.08	28509920
223	Phosphorylation	SKYNLPLTKITSAKR HHCCCCCHHHCCCCC	20.61	28509920
226	Phosphorylation	NLPLTKITSAKRNEN CCCCHHHCCCCCCCC	24.96	28509920
227	Phosphorylation	LPLTKITSAKRNENN CCCHHHCCCCCCCCC	34.95	25262027
254	Ubiquitination	KQEKKPFKNTENIKN HHHCCCCCCCCHHHC	72.05	29967540
260	Ubiquitination	FKNTENIKNSHLKKS CCCCCHHHCHHHHHH	65.07	29967540
276	Ubiquitination	FLTEVSQKENYAGAK HHHHHHCCCCCCCCC	40.18	29967540
279	Phosphorylation	EVSQKENYAGAKFSD HHHCCCCCCCCCCCC	13.91	29496907
285	Phosphorylation	NYAGAKFSDPPSPSV CCCCCCCCCCCCCCC	48.80	26471730
289	Phosphorylation	AKFSDPPSPSVLPKP CCCCCCCCCCCCCCC	34.88	26471730
291	Phosphorylation	FSDPPSPSVLPKPPS CCCCCCCCCCCCCCC	40.39	26471730
298	Phosphorylation	SVLPKPPSHWMGSTV CCCCCCCCCCCCCCC	38.00	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNRC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PNRC1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.