dbPTM

PRGC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRGC1_HUMAN
UniProt AC	Q9UBK2
Protein Name	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Gene Name	PPARGC1A
Organism	Homo sapiens (Human).
Sequence Length	798
Subcellular Localization	Isoform 1: Nucleus. Nucleus, PML body. Isoform B4: Nucleus. Isoform B4-8a: Cytoplasm. Nucleus. Isoform B5: Nucleus. Nucleus, PML body. Isoform 9: Nucleus .
Protein Description	Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK..
Protein Sequence	MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Acetylation	EPSNIFEKIDEENEA CCCCHHHHCCCCCHH	44.71	15744310
142	Phosphorylation	PQEAEEPSLLKKLLL CHHHCCCCHHHHHHH	50.00	24719451
145	Acetylation	AEEPSLLKKLLLAPA HCCCCHHHHHHHCCC	46.82	15744310
146	Acetylation	EEPSLLKKLLLAPAN CCCCHHHHHHHCCCC	44.32	15744310
178	Phosphorylation	NHNHRIRTNPAIVKT CCCCCCCCCCCEEEC	43.09	-
184	Acetylation	RTNPAIVKTENSWSN CCCCCEEECCCCCCH	43.97	15744310
208	Phosphorylation	KPQRRPCSELLKYLT CCCCCCHHHHHHHHH	33.68	-
242	Phosphorylation	KCTSKKKSHTQSQSQ HHHHCHHCCCHHHHH	40.42	28122231
244	Phosphorylation	TSKKKSHTQSQSQHL HHCHHCCCHHHHHHH	36.69	25850435
246	Phosphorylation	KKKSHTQSQSQHLQA CHHCCCHHHHHHHCC	32.71	25850435
248	Phosphorylation	KSHTQSQSQHLQAKP HCCCHHHHHHHCCCC	25.47	25850435
254	Acetylation	QSQHLQAKPTTLSLP HHHHHCCCCCEEECC	29.90	15744310
256	Phosphorylation	QHLQAKPTTLSLPLT HHHCCCCCEEECCCC	39.40	26270265
257	Phosphorylation	HLQAKPTTLSLPLTP HHCCCCCEEECCCCC	23.91	26270265
259	Phosphorylation	QAKPTTLSLPLTPES CCCCCEEECCCCCCC	26.33	29255136
263	Phosphorylation	TTLSLPLTPESPNDP CEEECCCCCCCCCCC	24.07	29255136
266	Phosphorylation	SLPLTPESPNDPKGS ECCCCCCCCCCCCCC	30.15	29255136
271	Acetylation	PESPNDPKGSPFENK CCCCCCCCCCCCCCC	74.92	15744310
273	Phosphorylation	SPNDPKGSPFENKTI CCCCCCCCCCCCCCE	32.32	29255136
278	Acetylation	KGSPFENKTIERTLS CCCCCCCCCEEEEEE	43.62	15744310
285	Phosphorylation	KTIERTLSVELSGTA CCEEEEEEEEEECCC	16.97	-
295	Phosphorylation	LSGTAGLTPPTTPPH EECCCCCCCCCCCCC	26.72	-
299	Phosphorylation	AGLTPPTTPPHKANQ CCCCCCCCCCCCCCC	40.37	22817900
313	Phosphorylation	QDNPFRASPKLKSSC CCCCCCCCHHHHHCC	20.50	25159151
321	Acetylation	PKLKSSCKTVVPPPS HHHHHCCCCCCCCCC	46.43	15744310
347	Acetylation	QGNNSTKKGPEQSEL CCCCCCCCCHHHHHH	78.69	15744310
360	Acetylation	ELYAQLSKSSVLTGG HHHHHHCHHCCCCCC	56.17	11795013
360	Ubiquitination	ELYAQLSKSSVLTGG HHHHHHCHHCCCCCC	56.17	-
413	Acetylation	DSRQLENKDVSSDWQ HHHHHCCCCCCCCCC	50.56	15744310
416	Phosphorylation	QLENKDVSSDWQGQI HHCCCCCCCCCCCCC	32.48	-
417	Phosphorylation	LENKDVSSDWQGQIC HCCCCCCCCCCCCCC	42.59	-
442	Ubiquitination	RETLEASKQVSPCST HHHHHHHCCCCCCCC	62.86	15744310
442	Acetylation	RETLEASKQVSPCST HHHHHHHCCCCCCCC	62.86	15744310
451	Acetylation	VSPCSTRKQLQDQEI CCCCCCHHHHHHHHH	56.29	15744310
464	Ubiquitination	EIRAELNKHFGHPSQ HHHHHHHHHHCCHHH	53.59	-
480	Ubiquitination	VFDDEADKTGELRDS CCCCCCCCCCCCCCC	66.53	-
539	Phosphorylation	SLFNVSPSCSSFNSP EEEEECCCHHHCCCC	21.08	-
552	Phosphorylation	SPCRDSVSPPKSLFS CCCCCCCCCCHHHHC	39.16	24719451
571	Phosphorylation	RMRSRSRSFSRHRSC HHHHCCCHHHCCCCC	28.90	22817900
573	Phosphorylation	RSRSRSFSRHRSCSR HHCCCHHHCCCCCCC	28.55	17081983
579	Phosphorylation	FSRHRSCSRSPYSRS HHCCCCCCCCCCCCC	36.72	27174698
581	Phosphorylation	RHRSCSRSPYSRSRS CCCCCCCCCCCCCCC	16.34	27174698
583	Phosphorylation	RSCSRSPYSRSRSRS CCCCCCCCCCCCCCC	20.26	27174698
584	Phosphorylation	SCSRSPYSRSRSRSP CCCCCCCCCCCCCCC	27.45	27174698
586	Phosphorylation	SRSPYSRSRSRSPGS CCCCCCCCCCCCCCC	28.77	23312004
588	Phosphorylation	SPYSRSRSRSPGSRS CCCCCCCCCCCCCCC	38.05	23403867
590	Phosphorylation	YSRSRSRSPGSRSSS CCCCCCCCCCCCCCC	34.55	23403867
593	Phosphorylation	SRSRSPGSRSSSRSC CCCCCCCCCCCCCCE	32.16	23532336
596	Phosphorylation	RSPGSRSSSRSCYYY CCCCCCCCCCCEEEE	28.76	23403867
599	Phosphorylation	GSRSSSRSCYYYESS CCCCCCCCEEEECCC	14.39	30576142
606	Phosphorylation	SCYYYESSHYRHRTH CEEEECCCCCCCCCC	16.76	30576142
608	Phosphorylation	YYYESSHYRHRTHRN EEECCCCCCCCCCCC	15.29	30576142
612	Phosphorylation	SSHYRHRTHRNSPLY CCCCCCCCCCCCCEE	21.04	24275569
616	Phosphorylation	RHRTHRNSPLYVRSR CCCCCCCCCEEECCC	19.08	28857561
624	Phosphorylation	PLYVRSRSRSPYSRR CEEECCCCCCCCCCC	38.05	27174698
626	Phosphorylation	YVRSRSRSPYSRRPR EECCCCCCCCCCCCC	29.45	27174698
628	Phosphorylation	RSRSRSPYSRRPRYD CCCCCCCCCCCCCCC	18.96	27174698
629	Phosphorylation	SRSRSPYSRRPRYDS CCCCCCCCCCCCCCC	25.79	27174698
634	Phosphorylation	PYSRRPRYDSYEEYQ CCCCCCCCCCHHHHH	16.36	30576142
636	Phosphorylation	SRRPRYDSYEEYQHE CCCCCCCCHHHHHHH	26.05	30576142
637	Phosphorylation	RRPRYDSYEEYQHER CCCCCCCHHHHHHHH	15.19	23312004
665	Methylation	ESERAKQRERQRQKA HHHHHHHHHHHHHHH	40.12	-
667	Methylation	ERAKQRERQRQKAIE HHHHHHHHHHHHHHH	38.89	-
669	Methylation	AKQRERQRQKAIEER HHHHHHHHHHHHHHC	46.30	-
717	Phosphorylation	LRDDGDSYGFITYRY ECCCCCCEEEEEEEE	22.31	-
721	Phosphorylation	GDSYGFITYRYTCDA CCCEEEEEEEEEHHH	10.33	-
722	Phosphorylation	DSYGFITYRYTCDAF CCEEEEEEEEEHHHH	9.23	-
737	Phosphorylation	AALENGYTLRRSNET HHHHCCEEEECCCCC	18.39	24719451
758	Ubiquitination	CGRKQFFKSNYADLD ECCHHHHHCCCCCCC	38.80	15744310
758	Acetylation	CGRKQFFKSNYADLD ECCHHHHHCCCCCCC	38.80	15744310
768	Phosphorylation	YADLDSNSDDFDPAS CCCCCCCCCCCCCCC	42.37	-
777	Ubiquitination	DFDPASTKSKYDSLD CCCCCCCHHHHHCCC	42.32	-
779	Ubiquitination	DPASTKSKYDSLDFD CCCCCHHHHHCCCHH	55.41	15744310
779	Acetylation	DPASTKSKYDSLDFD CCCCCHHHHHCCCHH	55.41	15744310
782	Phosphorylation	STKSKYDSLDFDSLL CCHHHHHCCCHHHHH	27.09	-
787	Phosphorylation	YDSLDFDSLLKEAQR HHCCCHHHHHHHHHH	35.28	24719451
790	Ubiquitination	LDFDSLLKEAQRSLR CCHHHHHHHHHHHHH	57.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	T	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
263	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
263	T	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
263	T	Phosphorylation	Kinase	P38_GROUP	-	PhosphoELM
266	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
266	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
266	S	Phosphorylation	Kinase	P38_GROUP	-	PhosphoELM
299	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
299	T	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
299	T	Phosphorylation	Kinase	P38_GROUP	-	PhosphoELM
539	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	RNF34	Q969K3	PMID:22064484

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRGC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRGC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR1H4_HUMAN	NR1H4	physical	14729567
MED1_HUMAN	MED1	physical	14636573
MED16_HUMAN	MED16	physical	14636573
MED17_HUMAN	MED17	physical	14636573
MED21_HUMAN	MED21	physical	14636573
MED12_HUMAN	MED12	physical	14636573
MED14_HUMAN	MED14	physical	14636573
MED20_HUMAN	MED20	physical	14636573
PPARG_HUMAN	PPARG	physical	14636573
HCFC1_HUMAN	HCFC1	physical	11733490
ESR1_HUMAN	ESR1	physical	10748020
THB_HUMAN	THRB	physical	11751919
SRSF5_HUMAN	SRSF5	physical	10983978
SRSF6_HUMAN	SRSF6	physical	10983978
SRSF4_HUMAN	SRSF4	physical	10983978
PPARA_HUMAN	PPARA	physical	10669761
RXRA_HUMAN	RXRA	physical	11714715
GCR_HUMAN	NR3C1	physical	10713165
NCOA1_HUMAN	NCOA1	physical	10558993
CBP_HUMAN	CREBBP	physical	10558993
PPARG_HUMAN	PPARG	physical	10558993
ERR3_MOUSE	Esrrg	genetic	12470660
FBXW7_HUMAN	FBXW7	physical	18198341
EP300_HUMAN	EP300	physical	17050673
IQGA1_HUMAN	IQGAP1	physical	17050673
LPPRC_HUMAN	LRPPRC	physical	17050673
SIR1_HUMAN	SIRT1	physical	19553684
MYOD1_HUMAN	MYOD1	physical	19553684
NR1I2_HUMAN	NR1I2	physical	15322103
HNF4A_HUMAN	HNF4A	physical	15322103
SF01_HUMAN	SF1	physical	20133449
NR5A2_HUMAN	NR5A2	physical	20133449
RNF34_HUMAN	RNF34	physical	22064484
ERR1_HUMAN	ESRRA	physical	12181319
PPARG_HUMAN	PPARG	physical	17468099
HNF4A_HUMAN	HNF4A	physical	22009745
HNF4A_HUMAN	HNF4A	physical	22155889
P53_HUMAN	TP53	physical	22099309
RING2_HUMAN	RNF2	physical	22099309
SFPQ_HUMAN	SFPQ	physical	18689799
AAPK1_HUMAN	PRKAA1	physical	24371122
KAT2A_HUMAN	KAT2A	physical	24371122
SIR1_HUMAN	SIRT1	physical	15716268
PPARG_HUMAN	PPARG	physical	18674809
NRIP1_HUMAN	NRIP1	physical	19625249
PPARG_HUMAN	PPARG	physical	18469005
PPARG_HUMAN	PPARG	physical	17704298
NFKB1_HUMAN	NFKB1	physical	17785586
TF65_HUMAN	RELA	physical	17785586
PPARG_HUMAN	PPARG	physical	17785586
PPARG_HUMAN	PPARG	physical	19596656
PPARD_HUMAN	PPARD	physical	19596656
USF2_HUMAN	USF2	physical	12611894
USF1_HUMAN	USF1	physical	12611894
EWS_HUMAN	EWSR1	physical	25918410
NR1I3_HUMAN	NR1I3	physical	26407237
PML_HUMAN	PML	physical	26407237
NR4A2_HUMAN	NR4A2	physical	21757690
NR1I2_HUMAN	NR1I2	physical	16455805
NR1I2_HUMAN	NR1I2	physical	15331348
HNF4A_HUMAN	HNF4A	physical	15331348
NECD_HUMAN	NDN	physical	26971449

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRGC1_HUMAN

Related Literatures of Post-Translational Modification