dbPTM

SRSF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRSF4_HUMAN
UniProt AC	Q08170
Protein Name	Serine/arginine-rich splicing factor 4
Gene Name	SRSF4
Organism	Homo sapiens (Human).
Sequence Length	494
Subcellular Localization	Nucleus speckle .
Protein Description	Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10..
Protein Sequence	MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MPRVYIGRLSYQARE CCCEEEECCCHHHHH	15.76	80702415
23	Acetylation	RDVERFFKGYGKILE HHHHHHHHCCCCEEE	48.81	26051181
23	Ubiquitination	RDVERFFKGYGKILE HHHHHHHHCCCCEEE	48.81	23000965
27	Acetylation	RFFKGYGKILEVDLK HHHHCCCCEEEEECC	35.32	26051181
27	Ubiquitination	RFFKGYGKILEVDLK HHHHCCCCEEEEECC	35.32	23000965
53	Phosphorylation	RDADDAVYELNGKDL CCCCCHHHEECCCCC	19.20	30174305
58	Acetylation	AVYELNGKDLCGERV HHHEECCCCCCCCEE	46.59	26051181
58	Ubiquitination	AVYELNGKDLCGERV HHHEECCCCCCCCEE	46.59	29967540
71	Methylation	RVIVEHARGPRRDGS EEEEECCCCCCCCCC	58.52	-
78	Phosphorylation	RGPRRDGSYGSGRSG CCCCCCCCCCCCCCC	30.52	20363803
79	Phosphorylation	GPRRDGSYGSGRSGY CCCCCCCCCCCCCCC	22.35	29052541
81	Phosphorylation	RRDGSYGSGRSGYGY CCCCCCCCCCCCCCC	23.85	26853621
83	Methylation	DGSYGSGRSGYGYRR CCCCCCCCCCCCCCC	28.71	54559241
84	Phosphorylation	GSYGSGRSGYGYRRS CCCCCCCCCCCCCCC	39.63	23917254
95	Acetylation	YRRSGRDKYGPPTRT CCCCCCCCCCCCCHH	51.23	25953088
102	Phosphorylation	KYGPPTRTEYRLIVE CCCCCCHHHHHHHHC	39.59	28152594
104	Phosphorylation	GPPTRTEYRLIVENL CCCCHHHHHHHHCCH	15.31	28152594
112	Phosphorylation	RLIVENLSSRCSWQD HHHHCCHHHCCCHHH	27.58	29255136
113	Phosphorylation	LIVENLSSRCSWQDL HHHCCHHHCCCHHHH	40.24	19664994
116	Phosphorylation	ENLSSRCSWQDLKDY CCHHHCCCHHHHHHH	27.02	25159151
121	Acetylation	RCSWQDLKDYMRQAG CCCHHHHHHHHHHCC	55.92	26051181
131	Phosphorylation	MRQAGEVTYADAHKG HHHCCCCEEHHCCCC	14.53	28152594
132	Nitration	RQAGEVTYADAHKGR HHCCCCEEHHCCCCC	13.99	-
132	Phosphorylation	RQAGEVTYADAHKGR HHCCCCEEHHCCCCC	13.99	28152594
149	Phosphorylation	EGVIEFVSYSDMKRA CCEEEEECHHHHHHH	25.00	26270265
150	Phosphorylation	GVIEFVSYSDMKRAL CEEEEECHHHHHHHH	11.91	21712546
151	Phosphorylation	VIEFVSYSDMKRALE EEEEECHHHHHHHHH	24.59	21815630
154	Acetylation	FVSYSDMKRALEKLD EECHHHHHHHHHHCC	39.24	25953088
159	Acetylation	DMKRALEKLDGTEVN HHHHHHHHCCCCEEC	53.37	25953088
159	Ubiquitination	DMKRALEKLDGTEVN HHHHHHHHCCCCEEC	53.37	29967540
176	Acetylation	KIRLVEDKPGSRRRR EEEEECCCCCCCCCC	37.46	23749302
179	Phosphorylation	LVEDKPGSRRRRSYS EECCCCCCCCCCHHH	31.01	29255136
184	Phosphorylation	PGSRRRRSYSRSRSH CCCCCCCHHHHCCCC	26.16	26074081
185	Phosphorylation	GSRRRRSYSRSRSHS CCCCCCHHHHCCCCC	13.29	17081983
186	Phosphorylation	SRRRRSYSRSRSHSR CCCCCHHHHCCCCCC	25.65	26074081
188	Phosphorylation	RRRSYSRSRSHSRSR CCCHHHHCCCCCCHH	31.99	26074081
190	Phosphorylation	RSYSRSRSHSRSRSR CHHHHCCCCCCHHHH	27.36	26074081
192	Phosphorylation	YSRSRSHSRSRSRSR HHHCCCCCCHHHHCH	32.95	26074081
206	Phosphorylation	RHSRKSRSRSGSSKS HHCHHCCCCCCCCCC	37.58	22964224
208	Phosphorylation	SRKSRSRSGSSKSSH CHHCCCCCCCCCCCC	44.25	22964224
210	Phosphorylation	KSRSRSGSSKSSHSK HCCCCCCCCCCCCCC	35.52	22964224
211	Phosphorylation	SRSRSGSSKSSHSKS CCCCCCCCCCCCCCC	39.83	22964224
222	Phosphorylation	HSKSRSRSRSGSRSR CCCCCCCCCCCCHHH	31.85	22817900
232	Phosphorylation	GSRSRSKSRSRSQSR CCHHHHHHHHHHHHH	36.41	-
238	Phosphorylation	KSRSRSQSRSRSKKE HHHHHHHHHHHHHHH	33.21	-
255	Phosphorylation	RSPSKEKSRSRSHSA CCCCHHHHHHHHHHH	36.26	22817900
257	Phosphorylation	PSKEKSRSRSHSAGK CCHHHHHHHHHHHCC	45.27	-
259	Phosphorylation	KEKSRSRSHSAGKSR HHHHHHHHHHHCCCC	24.04	28176443
261	Phosphorylation	KSRSRSHSAGKSRSK HHHHHHHHHCCCCCC	39.71	20068231
264	Acetylation	SRSHSAGKSRSKSKD HHHHHHCCCCCCCHH	42.27	7431965
265	Phosphorylation	RSHSAGKSRSKSKDQ HHHHHCCCCCCCHHH	40.65	20068231
267	Phosphorylation	HSAGKSRSKSKDQAE HHHCCCCCCCHHHHH	48.66	30576142
269	Phosphorylation	AGKSRSKSKDQAEEK HCCCCCCCHHHHHHH	42.59	29743597
276	Acetylation	SKDQAEEKIQNNDNV CHHHHHHHHHCCCCC	40.89	26051181
285	Acetylation	QNNDNVGKPKSRSPS HCCCCCCCCCCCCCC	45.01	25953088
287	Acetylation	NDNVGKPKSRSPSRH CCCCCCCCCCCCCHH	63.08	19826789
288	Phosphorylation	DNVGKPKSRSPSRHK CCCCCCCCCCCCHHH	46.66	23911959
290	Phosphorylation	VGKPKSRSPSRHKSK CCCCCCCCCCHHHCH	34.03	23911959
292	Phosphorylation	KPKSRSPSRHKSKSK CCCCCCCCHHHCHHH	48.54	23911959
296	Phosphorylation	RSPSRHKSKSKSRSR CCCCHHHCHHHHCCH	35.72	26074081
298	Phosphorylation	PSRHKSKSKSRSRSQ CCHHHCHHHHCCHHH	42.84	26074081
300	Phosphorylation	RHKSKSKSRSRSQER HHHCHHHHCCHHHHH	42.45	29743597
302	Phosphorylation	KSKSKSRSRSQERRV HCHHHHCCHHHHHHH	43.29	29743597
304	Phosphorylation	KSKSRSRSQERRVEE HHHHCCHHHHHHHHH	37.33	29743597
316	Phosphorylation	VEEEKRGSVSRGRSQ HHHHHHHCCCCCHHH	22.43	23401153
318	Phosphorylation	EEKRGSVSRGRSQEK HHHHHCCCCCHHHHH	30.62	20363803
322	Phosphorylation	GSVSRGRSQEKSLRQ HCCCCCHHHHHHHHH	45.58	30576142
326	Phosphorylation	RGRSQEKSLRQSRSR CCHHHHHHHHHHHHH	28.21	28102081
330	Phosphorylation	QEKSLRQSRSRSRSK HHHHHHHHHHHHHCC	26.28	28102081
332	Phosphorylation	KSLRQSRSRSRSKGG HHHHHHHHHHHCCCC	39.59	28102081
360	Phosphorylation	KRKGRKRSREESRSR HHHHHHHHHHHHHHH	47.26	-
364	Phosphorylation	RKRSREESRSRSRSR HHHHHHHHHHHHHHC	30.70	-
368	Phosphorylation	REESRSRSRSRSKSE HHHHHHHHHHCHHHH	35.54	-
399	Phosphorylation	KKKKKEDTDRSQSRS CCCCHHHCCHHHCCC	34.11	30242111
402	Phosphorylation	KKEDTDRSQSRSPSR CHHHCCHHHCCCCCC	35.00	30242111
404	Phosphorylation	EDTDRSQSRSPSRSV HHCCHHHCCCCCCHH	35.65	30242111
406	Phosphorylation	TDRSQSRSPSRSVSK CCHHHCCCCCCHHHH	32.26	27794612
408	O-linked_Glycosylation	RSQSRSPSRSVSKER HHHCCCCCCHHHHHH	38.13	30379171
408	Phosphorylation	RSQSRSPSRSVSKER HHHCCCCCCHHHHHH	38.13	27794612
410	Phosphorylation	QSRSPSRSVSKEREH HCCCCCCHHHHHHHH	34.77	23312004
412	Phosphorylation	RSPSRSVSKEREHAK CCCCCHHHHHHHHHH	30.00	23312004
420	Phosphorylation	KEREHAKSESSQREG HHHHHHHCHHHCCCC	43.42	28450419
422	Phosphorylation	REHAKSESSQREGRG HHHHHCHHHCCCCCC	38.57	28450419
423	Phosphorylation	EHAKSESSQREGRGE HHHHCHHHCCCCCCC	29.25	25394399
428	Methylation	ESSQREGRGESENAG HHHCCCCCCCCCCCC	40.74	115916761
431	Phosphorylation	QREGRGESENAGTNQ CCCCCCCCCCCCCCH	38.69	29255136
436	Phosphorylation	GESENAGTNQETRSR CCCCCCCCCHHHHHH	31.17	23927012
440	Phosphorylation	NAGTNQETRSRSRSN CCCCCHHHHHHCCCC	24.95	23927012
442	Phosphorylation	GTNQETRSRSRSNSK CCCHHHHHHCCCCCC	41.87	25159151
444	Phosphorylation	NQETRSRSRSNSKSK CHHHHHHCCCCCCCC	41.11	30108239
446	Phosphorylation	ETRSRSRSNSKSKPN HHHHHCCCCCCCCCC	46.86	23927012
448	Phosphorylation	RSRSRSNSKSKPNLP HHHCCCCCCCCCCCC	39.28	23401153
450	Phosphorylation	RSRSNSKSKPNLPSE HCCCCCCCCCCCCHH	53.84	23927012
456	Phosphorylation	KSKPNLPSESRSRSK CCCCCCCHHHHHHCH	51.90	30266825
458	Phosphorylation	KPNLPSESRSRSKSA CCCCCHHHHHHCHHH	39.63	23927012
460	Phosphorylation	NLPSESRSRSKSASK CCCHHHHHHCHHHHH	50.62	25463755
462	Phosphorylation	PSESRSRSKSASKTR CHHHHHHCHHHHHHH	32.01	20164059
464	Phosphorylation	ESRSRSKSASKTRSR HHHHHCHHHHHHHHH	38.73	26074081
466	Phosphorylation	RSRSKSASKTRSRSK HHHCHHHHHHHHHHH	41.47	26074081
470	Phosphorylation	KSASKTRSRSKSRSR HHHHHHHHHHHHHHC	46.25	26074081
472	Phosphorylation	ASKTRSRSKSRSRSA HHHHHHHHHHHHCCC	35.91	26074081
474	Phosphorylation	KTRSRSKSRSRSASR HHHHHHHHHHCCCCC	36.41	26074081
476	Phosphorylation	RSRSKSRSRSASRSP HHHHHHHHCCCCCCC	37.36	26074081
478	Phosphorylation	RSKSRSRSASRSPSR HHHHHHCCCCCCCCH	31.66	26074081
480	Phosphorylation	KSRSRSASRSPSRSR HHHHCCCCCCCCHHH	34.24	20363803
482	Phosphorylation	RSRSASRSPSRSRSR HHCCCCCCCCHHHCC	25.40	26074081
484	Phosphorylation	RSASRSPSRSRSRSH CCCCCCCCHHHCCCC	44.10	26074081
486	Phosphorylation	ASRSPSRSRSRSHSR CCCCCCHHHCCCCCC	38.66	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRSF4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRSF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRSF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRSF6_HUMAN	SRSF6	physical	16189514
HAP1_HUMAN	HAP1	physical	16169070
WRIP1_HUMAN	WRNIP1	physical	22939629
HTSF1_HUMAN	HTATSF1	physical	22365833
SRSF1_HUMAN	SRSF1	physical	22365833
SRRM2_HUMAN	SRRM2	physical	22365833
SNUT1_HUMAN	SART1	physical	22365833
PR38A_HUMAN	PRPF38A	physical	22365833
RNPS1_HUMAN	RNPS1	physical	22365833
SRSF2_HUMAN	SRSF2	physical	22365833
TRA2B_HUMAN	TRA2B	physical	22365833
SRS10_HUMAN	SRSF10	physical	22365833
TCAM1_HUMAN	TICAM1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRSF4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222; SER-255; SER-300;SER-302; SER-304; SER-316; SER-322; THR-440; SER-448; SER-460 ANDSER-462, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458; SER-460 ANDSER-462, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-53, AND MASSSPECTROMETRY.	15592455 [Abstract]