dbPTM

SRS10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRS10_HUMAN
UniProt AC	O75494
Protein Name	Serine/arginine-rich splicing factor 10
Gene Name	SRSF10
Organism	Homo sapiens (Human).
Sequence Length	262
Subcellular Localization	Nucleus speckle . Cytoplasm .
Protein Description	Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. [PubMed: 11684676]
Protein Sequence	MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRYLRPPN ------CCCCCCCCC	29.63	24719451
4	Phosphorylation	----MSRYLRPPNTS ----CCCCCCCCCCC	10.35	28152594
6	Methylation	--MSRYLRPPNTSLF --CCCCCCCCCCCEE	35.38	81453731
10	Phosphorylation	RYLRPPNTSLFVRNV CCCCCCCCCEEEEEC	32.36	24719451
11	Phosphorylation	YLRPPNTSLFVRNVA CCCCCCCCEEEEECC	26.84	28152594
15	Methylation	PNTSLFVRNVADDTR CCCCEEEEECCCCCC	25.27	115917845
21	Phosphorylation	VRNVADDTRSEDLRR EEECCCCCCCHHHHH	36.32	23401153
22	Methylation	RNVADDTRSEDLRRE EECCCCCCCHHHHHH	45.07	115917849
23	Phosphorylation	NVADDTRSEDLRREF ECCCCCCCHHHHHHH	37.24	29255136
40	Phosphorylation	YGPIVDVYVPLDFYT CCCEEEEEEEEHHHC	7.59	-
55	Phosphorylation	RRPRGFAYVQFEDVR CCCCCEEEEEEECCC	7.79	27642862
62	Methylation	YVQFEDVRDAEDALH EEEEECCCCHHHHHH	50.14	115917853
92	Phosphorylation	FAQGDRKTPNQMKAK ECCCCCCCCCCCCCC	28.50	23401153
99	Acetylation	TPNQMKAKEGRNVYS CCCCCCCCCCCCCCC	56.00	11922409
105	Phosphorylation	AKEGRNVYSSSRYDD CCCCCCCCCCCCCCC	13.34	23927012
106	Phosphorylation	KEGRNVYSSSRYDDY CCCCCCCCCCCCCCH	19.97	25159151
107	Phosphorylation	EGRNVYSSSRYDDYD CCCCCCCCCCCCCHH	10.93	30266825
108	Phosphorylation	GRNVYSSSRYDDYDR CCCCCCCCCCCCHHH	28.99	23927012
110	Phosphorylation	NVYSSSRYDDYDRYR CCCCCCCCCCHHHHH	18.34	23927012
113	Phosphorylation	SSSRYDDYDRYRRSR CCCCCCCHHHHHHHH	10.22	23403867
116	Phosphorylation	RYDDYDRYRRSRSRS CCCCHHHHHHHHCHH	13.89	23186163
119	Phosphorylation	DYDRYRRSRSRSYER CHHHHHHHHCHHHHH	26.13	23898821
121	Phosphorylation	DRYRRSRSRSYERRR HHHHHHHCHHHHHHH	27.16	26055452
123	Phosphorylation	YRRSRSRSYERRRSR HHHHHCHHHHHHHHH	32.37	26055452
124	Phosphorylation	RRSRSRSYERRRSRS HHHHCHHHHHHHHHC	16.61	30576142
129	Phosphorylation	RSYERRRSRSRSFDY HHHHHHHHHCCCCCC	32.56	26846344
131	Phosphorylation	YERRRSRSRSFDYNY HHHHHHHCCCCCCCC	33.26	22167270
133	Phosphorylation	RRRSRSRSFDYNYRR HHHHHCCCCCCCCCC	24.58	19664994
133 (in isoform 2)	Phosphorylation	-	24.58	25849741
133 (in isoform 6)	Phosphorylation	-	24.58	25849741
136	Phosphorylation	SRSRSFDYNYRRSYS HHCCCCCCCCCCCCC	16.45	26846344
136 (in isoform 2)	Phosphorylation	-	16.45	29116813
136 (in isoform 6)	Phosphorylation	-	16.45	29116813
138	Phosphorylation	SRSFDYNYRRSYSPR CCCCCCCCCCCCCCC	10.94	23927012
141	Phosphorylation	FDYNYRRSYSPRNSR CCCCCCCCCCCCCCC	22.44	21955146
141 (in isoform 2)	Phosphorylation	-	22.44	25849741
141 (in isoform 5)	Phosphorylation	-	22.44	24719451
141 (in isoform 6)	Phosphorylation	-	22.44	25849741
142	Phosphorylation	DYNYRRSYSPRNSRP CCCCCCCCCCCCCCC	22.38	23403867
142 (in isoform 5)	Phosphorylation	-	22.38	28450419
143	Phosphorylation	YNYRRSYSPRNSRPT CCCCCCCCCCCCCCC	20.73	21955146
143 (in isoform 2)	Phosphorylation	-	20.73	25849741
143 (in isoform 5)	Phosphorylation	-	20.73	28450419
143 (in isoform 6)	Phosphorylation	-	20.73	25849741
147	Phosphorylation	RSYSPRNSRPTGRPR CCCCCCCCCCCCCCC	40.70	23186163
150	Phosphorylation	SPRNSRPTGRPRRSR CCCCCCCCCCCCCCC	44.72	24719451
150 (in isoform 5)	Phosphorylation	-	44.72	28450419
153 (in isoform 5)	Phosphorylation	-	37.06	27251275
155 (in isoform 2)	Phosphorylation	-	38.82	29116813
155 (in isoform 6)	Phosphorylation	-	38.82	22617229
156	Phosphorylation	PTGRPRRSRSHSDND CCCCCCCCCCCCCCH	39.14	26846344
156 (in isoform 3)	Phosphorylation	-	39.14	22617229
156 (in isoform 4)	Phosphorylation	-	39.14	23663014
157 (in isoform 2)	Phosphorylation	-	36.26	25849741
157 (in isoform 6)	Phosphorylation	-	36.26	22167270
158	Phosphorylation	GRPRRSRSHSDNDRF CCCCCCCCCCCCHHH	28.70	30266825
158 (in isoform 3)	Phosphorylation	-	28.70	22167270
158 (in isoform 4)	Phosphorylation	-	28.70	25849741
159 (in isoform 2)	Phosphorylation	-	37.75	25849741
159 (in isoform 6)	Phosphorylation	-	37.75	22167270
160	Phosphorylation	PRRSRSHSDNDRFKH CCCCCCCCCCHHHHH	39.08	30266825
160 (in isoform 3)	Phosphorylation	-	39.08	22167270
160 (in isoform 4)	Phosphorylation	-	39.08	23663014
164 (in isoform 4)	Phosphorylation	-	49.09	23663014
167 (in isoform 4)	Phosphorylation	-	29.54	20068231
167 (in isoform 6)	Phosphorylation	-	29.54	22167270
168 (in isoform 3)	Phosphorylation	-	40.63	22167270
170 (in isoform 6)	Phosphorylation	-	38.75	22167270
171	Phosphorylation	RFKHRNRSFSRSKSN HHHHHHHHHHHCCCC	30.99	20363803
171 (in isoform 3)	Phosphorylation	-	30.99	22167270
172 (in isoform 6)	Phosphorylation	-	6.76	22167270
173	Phosphorylation	KHRNRSFSRSKSNSR HHHHHHHHHCCCCCC	36.57	20363803
173 (in isoform 3)	Phosphorylation	-	36.57	22167270
173 (in isoform 6)	Phosphorylation	-	36.57	22167270
174 (in isoform 3)	Phosphorylation	-	46.20	22167270
174 (in isoform 6)	Phosphorylation	-	46.20	28450419
175	Phosphorylation	RNRSFSRSKSNSRSR HHHHHHHCCCCCCCC	38.96	20363803
175 (in isoform 3)	Phosphorylation	-	38.96	28450419
176 (in isoform 6)	Phosphorylation	-	53.17	28450419
177 (in isoform 3)	Phosphorylation	-	41.08	28450419
177 (in isoform 6)	Phosphorylation	-	41.08	20068231
178 (in isoform 3)	Phosphorylation	-	45.22	20068231
178 (in isoform 6)	Phosphorylation	-	45.22	20068231
179 (in isoform 3)	Phosphorylation	-	38.43	20068231
179 (in isoform 6)	Phosphorylation	-	38.43	20068231
180 (in isoform 3)	Phosphorylation	-	40.10	20068231
185	Phosphorylation	NSRSRSKSQPKKEMK CCCCCCCCCCHHHHH	53.62	26657352
195	Phosphorylation	KKEMKAKSRSRSASH HHHHHHHHHHCCCCC	40.11	30576142
197	Phosphorylation	EMKAKSRSRSASHTK HHHHHHHHCCCCCCC	37.36	30576142
199	Phosphorylation	KAKSRSRSASHTKTR HHHHHHCCCCCCCCC	35.06	30576142
201	Phosphorylation	KSRSRSASHTKTRGT HHHHCCCCCCCCCCC	32.70	28176443
203	Phosphorylation	RSRSASHTKTRGTSK HHCCCCCCCCCCCCC	31.45	28176443
205	Phosphorylation	RSASHTKTRGTSKTD CCCCCCCCCCCCCCC	35.17	23312004
208	Phosphorylation	SHTKTRGTSKTDSKT CCCCCCCCCCCCCCC	24.61	24719451
209	Phosphorylation	HTKTRGTSKTDSKTH CCCCCCCCCCCCCCC	36.06	30576142
211	Phosphorylation	KTRGTSKTDSKTHYK CCCCCCCCCCCCCCC	45.32	26074081
213	Phosphorylation	RGTSKTDSKTHYKSG CCCCCCCCCCCCCCC	44.69	26657352
215	Phosphorylation	TSKTDSKTHYKSGSR CCCCCCCCCCCCCCC	34.10	26074081
217	Phosphorylation	KTDSKTHYKSGSRYE CCCCCCCCCCCCCCC	16.45	26074081
219	Phosphorylation	DSKTHYKSGSRYEKE CCCCCCCCCCCCCHH	34.53	26074081
221	Phosphorylation	KTHYKSGSRYEKESR CCCCCCCCCCCHHHC	38.49	24719451
223	Phosphorylation	HYKSGSRYEKESRKK CCCCCCCCCHHHCCC	32.81	26074081
235	Phosphorylation	RKKEPPRSKSQSRSQ CCCCCCCCHHHHHHH	42.29	26657352
237	O-linked_Glycosylation	KEPPRSKSQSRSQSR CCCCCCHHHHHHHHH	34.33	30379171
239	O-linked_Glycosylation	PPRSKSQSRSQSRSR CCCCHHHHHHHHHHC	40.78	30379171
249	Phosphorylation	QSRSRSKSRSRSWTS HHHHCHHHHCCCCCC	36.41	20164059
251	Phosphorylation	RSRSKSRSRSWTSPK HHCHHHHCCCCCCCC	37.44	22167270
253	Phosphorylation	RSKSRSRSWTSPKSS CHHHHCCCCCCCCCC	35.63	22167270
255	Phosphorylation	KSRSRSWTSPKSSGH HHHCCCCCCCCCCCC	36.08	22167270
256	Phosphorylation	SRSRSWTSPKSSGH- HHCCCCCCCCCCCC-	24.87	28355574
259	Phosphorylation	RSWTSPKSSGH---- CCCCCCCCCCC----	44.96	23663014
260	Phosphorylation	SWTSPKSSGH----- CCCCCCCCCC-----	47.19	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRS10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRS10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRS10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRA2A_HUMAN	TRA2A	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
TRI55_HUMAN	TRIM55	physical	22939629
SYEP_HUMAN	EPRS	physical	22939629
TCRG1_HUMAN	TCERG1	physical	22939629
SPF27_HUMAN	BCAS2	physical	22939629
VASN_HUMAN	VASN	physical	22939629
THOC6_HUMAN	THOC6	physical	22939629
ZN687_HUMAN	ZNF687	physical	22939629
SNUT2_HUMAN	USP39	physical	22939629
TR112_HUMAN	TRMT112	physical	22939629
TCOF_HUMAN	TCOF1	physical	22939629
SMU1_HUMAN	SMU1	physical	22939629
SRSF6_HUMAN	SRSF6	physical	22939629
SRSF1_HUMAN	SRSF1	physical	22365833
SRSF4_HUMAN	SRSF4	physical	22365833
TRA2B_HUMAN	TRA2B	physical	22365833

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRS10_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-131 ANDSER-133, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-133, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-131 ANDSER-133, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-110; SER-129; SER-131;SER-133; SER-156; SER-158; SER-160; SER-235; SER-251; SER-253; THR-255AND SER-256, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, AND MASSSPECTROMETRY.	15302935 [Abstract]