dbPTM

IQGA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IQGA1_HUMAN
UniProt AC	P46940
Protein Name	Ras GTPase-activating-like protein IQGAP1
Gene Name	IQGAP1
Organism	Homo sapiens (Human).
Sequence Length	1657
Subcellular Localization	Cell membrane . Nucleus . Cytoplasm . Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).
Protein Description	Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. [PubMed: 15695813 May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest]
Protein Sequence	MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAADEVDG ------CCHHHCCCC	43.39	20068231
2	Phosphorylation	------MSAADEVDG ------CCHHHCCCC	43.39	23401153
17	Phosphorylation	LGVARPHYGSVLDNE CCCCCCCCCCCCCCC	17.49	25394399
19	Phosphorylation	VARPHYGSVLDNERL CCCCCCCCCCCCCCC	16.61	23401153
27	Phosphorylation	VLDNERLTAEEMDER CCCCCCCCHHHHHHH	37.94	26074081
31	Sulfoxidation	ERLTAEEMDERRRQN CCCCHHHHHHHHHHH	4.96	30846556
41	Phosphorylation	RRRQNVAYEYLCHLE HHHHHHHHHHHHCHH	10.79	27642862
51	2-Hydroxyisobutyrylation	LCHLEEAKRWMEACL HHCHHHHHHHHHHHH	50.28	-
51	Acetylation	LCHLEEAKRWMEACL HHCHHHHHHHHHHHH	50.28	26051181
51	Ubiquitination	LCHLEEAKRWMEACL HHCHHHHHHHHHHHH	50.28	-
77	Phosphorylation	EGLRNGVYLAKLGNF HHHHCCCCCCCCCCC	11.44	-
80	Acetylation	RNGVYLAKLGNFFSP HCCCCCCCCCCCCCH	55.09	26051181
86	Phosphorylation	AKLGNFFSPKVVSLK CCCCCCCCHHEEEEH	21.48	21815630
88	Acetylation	LGNFFSPKVVSLKKI CCCCCCHHEEEEHHH	54.81	26051181
88	Ubiquitination	LGNFFSPKVVSLKKI CCCCCCHHEEEEHHH	54.81	21906983
91	Phosphorylation	FFSPKVVSLKKIYDR CCCHHEEEEHHHHCC	37.14	24719451
96	Phosphorylation	VVSLKKIYDREQTRY EEEEHHHHCCCHHHH	20.16	-
104	Ubiquitination	DREQTRYKATGLHFR CCCHHHHHCCCCCCC	35.86	-
106	Phosphorylation	EQTRYKATGLHFRHT CHHHHHCCCCCCCCH	35.80	28555341
123	Sulfoxidation	VIQWLNAMDEIGLPK HHHHHHHHHHHCCCC	4.64	28183972
130	Ubiquitination	MDEIGLPKIFYPETT HHHHCCCCCCCCCCC	50.95	-
133	Phosphorylation	IGLPKIFYPETTDIY HCCCCCCCCCCCCCC	12.02	28152594
136	Phosphorylation	PKIFYPETTDIYDRK CCCCCCCCCCCCCCC	25.84	28152594
137	Phosphorylation	KIFYPETTDIYDRKN CCCCCCCCCCCCCCC	20.81	28152594
140	Phosphorylation	YPETTDIYDRKNMPR CCCCCCCCCCCCCCH	16.71	28152594
172	Phosphorylation	APQIQDLYGKVDFTE CHHHHHHHCCCCCCH	24.16	21945579
174	Ubiquitination	QIQDLYGKVDFTEEE HHHHHHCCCCCCHHH	25.69	-
178	Phosphorylation	LYGKVDFTEEEINNM HHCCCCCCHHHHHHH	37.71	21815630
185	Sulfoxidation	TEEEINNMKTELEKY CHHHHHHHHHHHHHH	5.00	21406390
186	Acetylation	EEEINNMKTELEKYG HHHHHHHHHHHHHHC	40.76	26051181
186	Ubiquitination	EEEINNMKTELEKYG HHHHHHHHHHHHHHC	40.76	-
187	Phosphorylation	EEINNMKTELEKYGI HHHHHHHHHHHHHCC	34.73	21601212
191	2-Hydroxyisobutyrylation	NMKTELEKYGIQMPA HHHHHHHHHCCCCCH	62.49	-
200	Phosphorylation	GIQMPAFSKIGGILA CCCCCHHHHHCCHHH	26.01	21712546
211	Phosphorylation	GILANELSVDEAALH CHHHHCCCCCHHHHH	22.73	30301811
246	Sulfoxidation	ALKNPNAMLVNLEEP HHHCCCCEEECCCCC	5.65	28183972
256	O-linked_Glycosylation	NLEEPLASTYQDILY CCCCCCHHHHHHHHH	35.02	23301498
266	Ubiquitination	QDILYQAKQDKMTNA HHHHHHHHHHHCCCC	43.43	-
280	Phosphorylation	AKNRTENSERERDVY CCCCCCCCHHHHHHH	31.62	28555341
287	Phosphorylation	SERERDVYEELLTQA CHHHHHHHHHHHHHH	14.15	28555341
330	Phosphorylation	ALFRALQSPALGLRG HHHHHHCCHHHCCCC	17.00	29255136
336	Methylation	QSPALGLRGLQQQNS CCHHHCCCCHHHHCC	41.81	115480411
348	Acetylation	QNSDWYLKQLLSDKQ HCCHHHHHHHHCHHH	24.17	23954790
348	Ubiquitination	QNSDWYLKQLLSDKQ HCCHHHHHHHHCHHH	24.17	21906983
354	2-Hydroxyisobutyrylation	LKQLLSDKQQKRQSG HHHHHCHHHHHHHCC	51.78	-
354	Ubiquitination	LKQLLSDKQQKRQSG HHHHHCHHHHHHHCC	51.78	-
360	Phosphorylation	DKQQKRQSGQTDPLQ HHHHHHHCCCCCHHH	36.58	25159151
368	Acetylation	GQTDPLQKEELQSGV CCCCHHHHHHHHHHH	61.92	26051181
385	Phosphorylation	ANSAAQQYQRRLAAV HHHHHHHHHHHHHHH	7.60	22817900
401	Malonylation	LINAAIQKGVAEKTV HHHHHHHCCCCHHHH	49.60	26320211
401	Ubiquitination	LINAAIQKGVAEKTV HHHHHHHCCCCHHHH	49.60	-
406	Ubiquitination	IQKGVAEKTVLELMN HHCCCCHHHHHHHHC	33.91	-
435	O-linked_Glycosylation	LYQKELATLQRQSPE HHHHHHHHHHHHCCC	35.73	23301498
435	Phosphorylation	LYQKELATLQRQSPE HHHHHHHHHHHHCCC	35.73	26699800
459	Phosphorylation	VAVEMLSSVALINRA HHHHHHHHHHHHHHH	13.88	22468782
480	Phosphorylation	NTVWKQLSSSVTGLT HHHHHHHHHCCCCCC	20.34	25850435
481	Phosphorylation	TVWKQLSSSVTGLTN HHHHHHHHCCCCCCC	37.10	25850435
482	Phosphorylation	VWKQLSSSVTGLTNI HHHHHHHCCCCCCCC	21.96	21815630
484	Phosphorylation	KQLSSSVTGLTNIEE HHHHHCCCCCCCCCH	28.55	21815630
487	Phosphorylation	SSSVTGLTNIEEENC HHCCCCCCCCCHHHH	35.18	25850435
503	2-Hydroxyisobutyrylation	RYLDELMKLKAQAHA HHHHHHHHHHHHHHH	60.50	-
503	Ubiquitination	RYLDELMKLKAQAHA HHHHHHHHHHHHHHH	60.50	21906983
556	Ubiquitination	LDEGDAQKTLQALQI CCCCCHHHHHHHHCC	53.58	21906983
557	Phosphorylation	DEGDAQKTLQALQIP CCCCHHHHHHHHCCC	16.42	23911959
579	Phosphorylation	LAEVAQHYQDTLIRA HHHHHHHHHHHHHHH	8.94	-
582	Phosphorylation	VAQHYQDTLIRAKRE HHHHHHHHHHHHHHH	14.46	28122231
598	Phosphorylation	AQEIQDESAVLWLDE HHHCCCHHHHHHHHH	31.78	28348404
642	Phosphorylation	ESGDVGKTLSALRSP HCCCHHHHHHHHHCC	21.73	28857561
644	Phosphorylation	GDVGKTLSALRSPDV CCHHHHHHHHHCCCC	30.41	25159151
648	Phosphorylation	KTLSALRSPDVGLYG HHHHHHHCCCCCEEE	26.71	25849741
654	Phosphorylation	RSPDVGLYGVIPECG HCCCCCEEEECCCCC	11.92	27155012
660	Glutathionylation	LYGVIPECGETYHSD EEEECCCCCCCCCHH	5.11	22555962
663	Phosphorylation	VIPECGETYHSDLAE ECCCCCCCCCHHHHH	16.30	21253578
672	2-Hydroxyisobutyrylation	HSDLAEAKKKKLAVG CHHHHHHHHHCEECC	57.54	-
672	Acetylation	HSDLAEAKKKKLAVG CHHHHHHHHHCEECC	57.54	26051181
672	Ubiquitination	HSDLAEAKKKKLAVG CHHHHHHHHHCEECC	57.54	-
675	2-Hydroxyisobutyrylation	LAEAKKKKLAVGDNN HHHHHHHCEECCCCC	51.03	-
683	Phosphorylation	LAVGDNNSKWVKHWV EECCCCCCHHHHHHH	33.86	20068231
684	Acetylation	AVGDNNSKWVKHWVK ECCCCCCHHHHHHHH	59.12	25953088
684	Ubiquitination	AVGDNNSKWVKHWVK ECCCCCCHHHHHHHH	59.12	-
687	Malonylation	DNNSKWVKHWVKGGY CCCCHHHHHHHHCCE	30.54	26320211
687	Ubiquitination	DNNSKWVKHWVKGGY CCCCHHHHHHHHCCE	30.54	-
694	Phosphorylation	KHWVKGGYYYYHNLE HHHHHCCEEEEECCC	9.28	-
695	Phosphorylation	HWVKGGYYYYHNLET HHHHCCEEEEECCCC	10.79	-
697	Phosphorylation	VKGGYYYYHNLETQE HHCCEEEEECCCCCC	2.85	22817900
718	Sulfoxidation	PNFVQNSMQLSREEI CCHHHHHHHCCHHHH	6.44	30846556
727	Phosphorylation	LSREEIQSSISGVTA CCHHHHHHHHHHHHH	34.99	20068231
728	Phosphorylation	SREEIQSSISGVTAA CHHHHHHHHHHHHHC	12.37	20068231
730	Phosphorylation	EEIQSSISGVTAAYN HHHHHHHHHHHHCCC	29.20	20068231
733	Phosphorylation	QSSISGVTAAYNREQ HHHHHHHHHCCCHHH	14.75	28152594
736	Phosphorylation	ISGVTAAYNREQLWL HHHHHHCCCHHHHHC	16.58	28152594
750	Phosphorylation	LANEGLITRLQARCR CCCCCHHHHHHHHHC	30.30	21601212
759	Phosphorylation	LQARCRGYLVRQEFR HHHHHCHHHHHHHHH	5.22	28152594
787	Methylation	TCIQSQWRGYKQKKA HHHHHHCCCHHHHHH	30.81	54556869
798	Methylation	QKKAYQDRLAYLRSH HHHHHHHHHHHHHHC	12.99	115480419
801	Phosphorylation	AYQDRLAYLRSHKDE HHHHHHHHHHHCCHH	13.77	28634120
804	Phosphorylation	DRLAYLRSHKDEVVK HHHHHHHHCCHHHHH	32.09	29496963
806	2-Hydroxyisobutyrylation	LAYLRSHKDEVVKIQ HHHHHHCCHHHHHHH	57.75	-
806	Succinylation	LAYLRSHKDEVVKIQ HHHHHHCCHHHHHHH	57.75	23954790
811	2-Hydroxyisobutyrylation	SHKDEVVKIQSLARM HCCHHHHHHHHHHHH	39.96	-
811	Ubiquitination	SHKDEVVKIQSLARM HCCHHHHHHHHHHHH	39.96	21906983
814	Phosphorylation	DEVVKIQSLARMHQA HHHHHHHHHHHHHHH	27.72	24719451
831	Phosphorylation	RYRDRLQYFRDHIND HHHHHHHHHHHHHHH	12.74	-
855	Phosphorylation	ANKARDDYKTLINAE HHCCCHHHHHHCCCC	15.34	29978859
856	Ubiquitination	NKARDDYKTLINAED HCCCHHHHHHCCCCC	43.80	-
857	Phosphorylation	KARDDYKTLINAEDP CCCHHHHHHCCCCCC	27.00	29978859
866	Sulfoxidation	INAEDPPMVVVRKFV CCCCCCCEEEEEHHH	4.32	21406390
871	Acetylation	PPMVVVRKFVHLLDQ CCEEEEEHHHHHHCC	39.88	26051181
879	Phosphorylation	FVHLLDQSDQDFQEE HHHHHCCCCHHHHHH	36.58	28348404
890	Sulfoxidation	FQEELDLMKMREEVI HHHHHHHHHHHHHHH	2.98	30846556
892	Sulfoxidation	EELDLMKMREEVITL HHHHHHHHHHHHHHH	3.98	21406390
902	Phosphorylation	EVITLIRSNQQLEND HHHHHHHCCHHHHHC	31.81	21712546
913	Sulfoxidation	LENDLNLMDIKIGLL HHHCCCCCHHHHHHH	4.94	21406390
916	Ubiquitination	DLNLMDIKIGLLVKN CCCCCHHHHHHHHCC	26.85	-
922	2-Hydroxyisobutyrylation	IKIGLLVKNKITLQD HHHHHHHCCCCCHHH	53.12	-
922	Acetylation	IKIGLLVKNKITLQD HHHHHHHCCCCCHHH	53.12	25953088
922	Methylation	IKIGLLVKNKITLQD HHHHHHHCCCCCHHH	53.12	115971513
922	Ubiquitination	IKIGLLVKNKITLQD HHHHHHHCCCCCHHH	53.12	-
924	Malonylation	IGLLVKNKITLQDVV HHHHHCCCCCHHHHH	31.20	26320211
924	Ubiquitination	IGLLVKNKITLQDVV HHHHHCCCCCHHHHH	31.20	-
932	Phosphorylation	ITLQDVVSHSKKLTK CCHHHHHHHHHHHCC	23.15	25159151
934	Phosphorylation	LQDVVSHSKKLTKKN HHHHHHHHHHHCCCC	24.79	25159151
935	2-Hydroxyisobutyrylation	QDVVSHSKKLTKKNK HHHHHHHHHHCCCCH	46.51	-
935	Acetylation	QDVVSHSKKLTKKNK HHHHHHHHHHCCCCH	46.51	25953088
935	Malonylation	QDVVSHSKKLTKKNK HHHHHHHHHHCCCCH	46.51	26320211
935	Succinylation	QDVVSHSKKLTKKNK HHHHHHHHHHCCCCH	46.51	23954790
935	Ubiquitination	QDVVSHSKKLTKKNK HHHHHHHHHHCCCCH	46.51	-
936	Ubiquitination	DVVSHSKKLTKKNKE HHHHHHHHHCCCCHH	65.49	-
940	Ubiquitination	HSKKLTKKNKEQLSD HHHHHCCCCHHHHHH	68.93	-
942	2-Hydroxyisobutyrylation	KKLTKKNKEQLSDMM HHHCCCCHHHHHHHH	56.57	-
942	Methylation	KKLTKKNKEQLSDMM HHHCCCCHHHHHHHH	56.57	83034435
942	Ubiquitination	KKLTKKNKEQLSDMM HHHCCCCHHHHHHHH	56.57	21906983
948	Sulfoxidation	NKEQLSDMMMINKQK CHHHHHHHHHHHHHC	1.44	30846556
949	Sulfoxidation	KEQLSDMMMINKQKG HHHHHHHHHHHHHCC	2.68	30846556
950	Sulfoxidation	EQLSDMMMINKQKGG HHHHHHHHHHHHCCH	2.16	30846556
953	Acetylation	SDMMMINKQKGGLKA HHHHHHHHHCCHHHH	42.32	26051181
953	Ubiquitination	SDMMMINKQKGGLKA HHHHHHHHHCCHHHH	42.32	21890473
959	Acetylation	NKQKGGLKALSKEKR HHHCCHHHHCCHHHH	51.02	12439083
959	Ubiquitination	NKQKGGLKALSKEKR HHHCCHHHHCCHHHH	51.02	-
962	Phosphorylation	KGGLKALSKEKREKL CCHHHHCCHHHHHHH	43.56	23312004
963	Acetylation	GGLKALSKEKREKLE CHHHHCCHHHHHHHH	69.01	12439095
965	Acetylation	LKALSKEKREKLEAY HHHCCHHHHHHHHHH	70.37	12439107
993	Sulfoxidation	LAKLIFQMPQNKSTK HHHHHHCCCCCCCCC	2.28	30846556
997	Acetylation	IFQMPQNKSTKFMDS HHCCCCCCCCCCHHH	55.01	25953088
997	Ubiquitination	IFQMPQNKSTKFMDS HHCCCCCCCCCCHHH	55.01	21890473
1002	Sulfoxidation	QNKSTKFMDSVIFTL CCCCCCCHHHHHHHH	3.91	28183972
1020	Phosphorylation	ASNQREEYLLLRLFK CCCCHHHHHHHHHHH	9.63	24114839
1027	Acetylation	YLLLRLFKTALQEEI HHHHHHHHHHHHHHH	37.16	25953088
1027	Malonylation	YLLLRLFKTALQEEI HHHHHHHHHHHHHHH	37.16	26320211
1027	Ubiquitination	YLLLRLFKTALQEEI HHHHHHHHHHHHHHH	37.16	-
1028	Phosphorylation	LLLRLFKTALQEEIK HHHHHHHHHHHHHHH	25.85	23312004
1035	2-Hydroxyisobutyrylation	TALQEEIKSKVDQIQ HHHHHHHHHHHHHHH	47.72	-
1035	Ubiquitination	TALQEEIKSKVDQIQ HHHHHHHHHHHHHHH	47.72	-
1037	Acetylation	LQEEIKSKVDQIQEI HHHHHHHHHHHHHHH	44.84	27452117
1037	Ubiquitination	LQEEIKSKVDQIQEI HHHHHHHHHHHHHHH	44.84	-
1057	Phosphorylation	TVIKMVVSFNRGARG CEEEEEEECCCCCHH	12.85	20873877
1083	2-Hydroxyisobutyrylation	VKEIMDDKSLNIKTD HHHHCCCCCCCCCCC	53.21	-
1083	Malonylation	VKEIMDDKSLNIKTD HHHHCCCCCCCCCCC	53.21	26320211
1083	Ubiquitination	VKEIMDDKSLNIKTD HHHHCCCCCCCCCCC	53.21	-
1088	Trimethylation	DDKSLNIKTDPVDIY CCCCCCCCCCHHHHH	45.89	-
1088	Acetylation	DDKSLNIKTDPVDIY CCCCCCCCCCHHHHH	45.89	23954790
1088	Malonylation	DDKSLNIKTDPVDIY CCCCCCCCCCHHHHH	45.89	26320211
1088	Methylation	DDKSLNIKTDPVDIY CCCCCCCCCCHHHHH	45.89	-
1088	Ubiquitination	DDKSLNIKTDPVDIY CCCCCCCCCCHHHHH	45.89	21890473
1089	Phosphorylation	DKSLNIKTDPVDIYK CCCCCCCCCHHHHHH	41.56	26552605
1095	Phosphorylation	KTDPVDIYKSWVNQM CCCHHHHHHHHHHHH	8.43	27080861
1096	Trimethylation	TDPVDIYKSWVNQME CCHHHHHHHHHHHHH	37.87	-
1096	Methylation	TDPVDIYKSWVNQME CCHHHHHHHHHHHHH	37.87	-
1096	Ubiquitination	TDPVDIYKSWVNQME CCHHHHHHHHHHHHH	37.87	-
1097	Phosphorylation	DPVDIYKSWVNQMES CHHHHHHHHHHHHHH	21.20	29507054
1102	Sulfoxidation	YKSWVNQMESQTGEA HHHHHHHHHHCCCCC	4.51	30846556
1104	Phosphorylation	SWVNQMESQTGEASK HHHHHHHHCCCCCCC	27.92	29978859
1106	Phosphorylation	VNQMESQTGEASKLP HHHHHHCCCCCCCCC	46.39	30576142
1110	Phosphorylation	ESQTGEASKLPYDVT HHCCCCCCCCCCCCC	30.35	29978859
1111	Acetylation	SQTGEASKLPYDVTP HCCCCCCCCCCCCCH	61.60	26051181
1111	Ubiquitination	SQTGEASKLPYDVTP HCCCCCCCCCCCCCH	61.60	21906983
1114	Phosphorylation	GEASKLPYDVTPEQA CCCCCCCCCCCHHHH	33.22	29978859
1117	Phosphorylation	SKLPYDVTPEQALAH CCCCCCCCHHHHHCC	20.43	30576142
1128	2-Hydroxyisobutyrylation	ALAHEEVKTRLDSSI HHCCHHHHHHHHHHH	31.07	-
1128	Acetylation	ALAHEEVKTRLDSSI HHCCHHHHHHHHHHH	31.07	26051181
1128	Ubiquitination	ALAHEEVKTRLDSSI HHCCHHHHHHHHHHH	31.07	-
1129	Phosphorylation	LAHEEVKTRLDSSIR HCCHHHHHHHHHHHH	41.46	29978859
1133	Phosphorylation	EVKTRLDSSIRNMRA HHHHHHHHHHHHHHH	32.05	24719451
1136	Methylation	TRLDSSIRNMRAVTD HHHHHHHHHHHHHHH	32.60	115480427
1144	2-Hydroxyisobutyrylation	NMRAVTDKFLSAIVS HHHHHHHHHHHHHHH	38.55	-
1144	Acetylation	NMRAVTDKFLSAIVS HHHHHHHHHHHHHHH	38.55	26051181
1144	Ubiquitination	NMRAVTDKFLSAIVS HHHHHHHHHHHHHHH	38.55	21906983
1147	Phosphorylation	AVTDKFLSAIVSSVD HHHHHHHHHHHHHHH	21.05	25850435
1151	Phosphorylation	KFLSAIVSSVDKIPY HHHHHHHHHHHCCCH	20.66	20068231
1152	Phosphorylation	FLSAIVSSVDKIPYG HHHHHHHHHHCCCHH	24.36	20068231
1155	Ubiquitination	AIVSSVDKIPYGMRF HHHHHHHCCCHHHHH	43.34	21906983
1158	Phosphorylation	SSVDKIPYGMRFIAK HHHHCCCHHHHHHHH	27.33	20068231
1165	Ubiquitination	YGMRFIAKVLKDSLH HHHHHHHHHHHHHHH	43.19	21906983
1168	2-Hydroxyisobutyrylation	RFIAKVLKDSLHEKF HHHHHHHHHHHHHHC	48.54	-
1168	Ubiquitination	RFIAKVLKDSLHEKF HHHHHHHHHHHHHHC	48.54	-
1174	2-Hydroxyisobutyrylation	LKDSLHEKFPDAGED HHHHHHHHCCCCCHH	51.99	-
1174	Acetylation	LKDSLHEKFPDAGED HHHHHHHHCCCCCHH	51.99	26051181
1174	Ubiquitination	LKDSLHEKFPDAGED HHHHHHHHCCCCCHH	51.99	-
1192	Phosphorylation	KIIGNLLYYRYMNPA HHHHHHHHHHHCCCC	6.78	28152594
1193	Phosphorylation	IIGNLLYYRYMNPAI HHHHHHHHHHCCCCC	8.67	28152594
1218	Phosphorylation	LSAGGQLTTDQRRNL ECCCCCCCHHHHHCH	22.05	-
1227	Phosphorylation	DQRRNLGSIAKMLQH HHHHCHHHHHHHHHH	23.65	-
1230	Acetylation	RNLGSIAKMLQHAAS HCHHHHHHHHHHHHC	38.17	25953088
1230	Malonylation	RNLGSIAKMLQHAAS HCHHHHHHHHHHHHC	38.17	26320211
1230	Ubiquitination	RNLGSIAKMLQHAAS HCHHHHHHHHHHHHC	38.17	21890473
1237	Phosphorylation	KMLQHAASNKMFLGD HHHHHHHCCCCCCCC	37.45	-
1261	Acetylation	YLSQSYQKFRRFFQT HHHHHHHHHHHHHHH	32.38	26051181
1263	Methylation	SQSYQKFRRFFQTAC HHHHHHHHHHHHHHC	41.34	115385669
1264	Methylation	QSYQKFRRFFQTACD HHHHHHHHHHHHHCC	39.60	115385677
1284	Phosphorylation	DKFNVDEYSDLVTLT HHCCCCCCCCCCCCC	11.74	27259358
1285	Phosphorylation	KFNVDEYSDLVTLTK HCCCCCCCCCCCCCC	23.56	30576142
1359	Phosphorylation	NKEALAKTEVSLTLT CHHHHHHEEEEEEEE	35.69	20068231
1362	Phosphorylation	ALAKTEVSLTLTNKF HHHHEEEEEEEECCC	14.92	28674419
1364	Phosphorylation	AKTEVSLTLTNKFDV HHEEEEEEEECCCCC	24.83	20068231
1366	Phosphorylation	TEVSLTLTNKFDVPG EEEEEEEECCCCCCC	31.00	20068231
1379	Sulfoxidation	PGDENAEMDARTILL CCCCCCCCCHHHHHH	4.54	21406390
1389	2-Hydroxyisobutyrylation	RTILLNTKRLIVDVI HHHHHCCCHHHEEEE	44.10	-
1389	Succinylation	RTILLNTKRLIVDVI HHHHHCCCHHHEEEE	44.10	23954790
1389	Ubiquitination	RTILLNTKRLIVDVI HHHHHCCCHHHEEEE	44.10	-
1403	Phosphorylation	IRFQPGETLTEILET EECCCCCCHHHHHHC	44.91	18452278
1405	Phosphorylation	FQPGETLTEILETPA CCCCCCHHHHHHCCC	28.53	28348404
1413	Phosphorylation	EILETPATSEQEAEH HHHHCCCCCHHHHHH	33.72	24719451
1434	Phosphorylation	RAIRDAKTPDKMKKS HHHHHCCCCCHHHCC	38.14	23403867
1441	Phosphorylation	TPDKMKKSKSVKEDS CCCHHHCCCCCCCCC	25.33	20201521
1442	Ubiquitination	PDKMKKSKSVKEDSN CCHHHCCCCCCCCCC	69.05	-
1443	Phosphorylation	DKMKKSKSVKEDSNL CHHHCCCCCCCCCCC	45.58	29255136
1445	2-Hydroxyisobutyrylation	MKKSKSVKEDSNLTL HHCCCCCCCCCCCCH	64.00	-
1445	Acetylation	MKKSKSVKEDSNLTL HHCCCCCCCCCCCCH	64.00	23954790
1445	Ubiquitination	MKKSKSVKEDSNLTL HHCCCCCCCCCCCCH	64.00	21906983
1448	Phosphorylation	SKSVKEDSNLTLQEK CCCCCCCCCCCHHHH	34.53	29255136
1451	Phosphorylation	VKEDSNLTLQEKKEK CCCCCCCCHHHHHHH	30.55	28102081
1464	2-Hydroxyisobutyrylation	EKIQTGLKKLTELGT HHHHHHHHHHHHCCC	47.27	-
1464	Acetylation	EKIQTGLKKLTELGT HHHHHHHHHHHHCCC	47.27	25953088
1464	Ubiquitination	EKIQTGLKKLTELGT HHHHHHHHHHHHCCC	47.27	-
1465	2-Hydroxyisobutyrylation	KIQTGLKKLTELGTV HHHHHHHHHHHCCCC	66.73	-
1465	Ubiquitination	KIQTGLKKLTELGTV HHHHHHHHHHHCCCC	66.73	21906983
1467	Phosphorylation	QTGLKKLTELGTVDP HHHHHHHHHCCCCCC	37.74	20068231
1471	Phosphorylation	KKLTELGTVDPKNKY HHHHHCCCCCCCHHH	34.07	20068231
1475	2-Hydroxyisobutyrylation	ELGTVDPKNKYQELI HCCCCCCCHHHHHHH	62.70	-
1475	Acetylation	ELGTVDPKNKYQELI HCCCCCCCHHHHHHH	62.70	26051181
1475	Malonylation	ELGTVDPKNKYQELI HCCCCCCCHHHHHHH	62.70	26320211
1475	Ubiquitination	ELGTVDPKNKYQELI HCCCCCCCHHHHHHH	62.70	-
1477	2-Hydroxyisobutyrylation	GTVDPKNKYQELIND CCCCCCHHHHHHHHH	55.21	-
1477	Acetylation	GTVDPKNKYQELIND CCCCCCHHHHHHHHH	55.21	25953088
1477	Ubiquitination	GTVDPKNKYQELIND CCCCCCHHHHHHHHH	55.21	21906983
1478	Phosphorylation	TVDPKNKYQELINDI CCCCCHHHHHHHHHH	19.33	28152594
1505	Ubiquitination	RRKAELVKLQQTYAA HHHHHHHHHHHHHHH	53.88	-
1509	Phosphorylation	ELVKLQQTYAALNSK HHHHHHHHHHHHHCC	11.36	28152594
1510	Phosphorylation	LVKLQQTYAALNSKA HHHHHHHHHHHHCCC	5.87	25159151
1515	Phosphorylation	QTYAALNSKATFYGE HHHHHHHCCCCCCHH	25.23	28152594
1516	Ubiquitination	TYAALNSKATFYGEQ HHHHHHCCCCCCHHH	50.82	-
1518	Phosphorylation	AALNSKATFYGEQVD HHHHCCCCCCHHHHH	22.56	28152594
1520	Phosphorylation	LNSKATFYGEQVDYY HHCCCCCCHHHHHHH	18.52	28152594
1526	Phosphorylation	FYGEQVDYYKSYIKT CCHHHHHHHHHHHHH	17.59	28152594
1527	Phosphorylation	YGEQVDYYKSYIKTC CHHHHHHHHHHHHHH	6.76	28152594
1528	2-Hydroxyisobutyrylation	GEQVDYYKSYIKTCL HHHHHHHHHHHHHHH	30.47	-
1528	Acetylation	GEQVDYYKSYIKTCL HHHHHHHHHHHHHHH	30.47	26051181
1528	Ubiquitination	GEQVDYYKSYIKTCL HHHHHHHHHHHHHHH	30.47	21906983
1532	Acetylation	DYYKSYIKTCLDNLA HHHHHHHHHHHHHHH	25.59	26051181
1532	Malonylation	DYYKSYIKTCLDNLA HHHHHHHHHHHHHHH	25.59	26320211
1532	Ubiquitination	DYYKSYIKTCLDNLA HHHHHHHHHHHHHHH	25.59	-
1533	Phosphorylation	YYKSYIKTCLDNLAS HHHHHHHHHHHHHHH	14.56	23312004
1534	S-nitrosylation	YKSYIKTCLDNLASK HHHHHHHHHHHHHHC	3.69	2212679
1540	Phosphorylation	TCLDNLASKGKVSKK HHHHHHHHCCCCCCC	45.14	30576142
1541	Malonylation	CLDNLASKGKVSKKP HHHHHHHCCCCCCCC	58.08	26320211
1541	Ubiquitination	CLDNLASKGKVSKKP HHHHHHHCCCCCCCC	58.08	-
1547	Acetylation	SKGKVSKKPREMKGK HCCCCCCCCCCCCCC	41.63	7266887
1552	Acetylation	SKKPREMKGKKSKKI CCCCCCCCCCCCCCC	63.93	7266899
1555	Acetylation	PREMKGKKSKKISLK CCCCCCCCCCCCCHH	75.95	7266911
1558	Acetylation	MKGKKSKKISLKYTA CCCCCCCCCCHHHHH	44.62	24885273
1562	Acetylation	KSKKISLKYTAARLH CCCCCCHHHHHHHHH	33.49	23954790
1562	Malonylation	KSKKISLKYTAARLH CCCCCCHHHHHHHHH	33.49	26320211
1562	Ubiquitination	KSKKISLKYTAARLH CCCCCCHHHHHHHHH	33.49	21890473
1571	2-Hydroxyisobutyrylation	TAARLHEKGVLLEIE HHHHHHHCCEEEEEE	43.50	-
1571	Acetylation	TAARLHEKGVLLEIE HHHHHHHCCEEEEEE	43.50	26051181
1571	Ubiquitination	TAARLHEKGVLLEIE HHHHHHHCCEEEEEE	43.50	-
1604	Ubiquitination	EVGDFEVKAKFMGVQ CCCCHHHEEHHCCCE	38.37	-
1655	Phosphorylation	FLLNKKFYGK----- HHHHHHHCCC-----	32.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1441	S	Phosphorylation	Kinase	PKC	-	Uniprot
1443	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
1443	S	Phosphorylation	Kinase	KPCE	Q02156	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1443	S	Phosphorylation	15355962
Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42.
1443	S	Phosphorylation	15355962
Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IQGA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAPCA_HUMAN	PRKACA	physical	12938160
AKAP5_HUMAN	AKAP5	physical	12938160
S100B_HUMAN	S100B	physical	12377780
CLIP1_HUMAN	CLIP1	physical	12110184
RAC1_HUMAN	RAC1	physical	12110184
CDC42_HUMAN	CDC42	physical	12110184
CTNB1_HUMAN	CTNNB1	physical	11734550
CADH1_HUMAN	CDH1	physical	10608854
CDC42_HUMAN	CDC42	physical	8670801
RPTOR_HUMAN	RPTOR	physical	22328503
AKT1_HUMAN	AKT1	physical	22328503
VGFR2_HUMAN	KDR	physical	19050761
ACTB_HUMAN	ACTB	physical	16179592
CY24B_HUMAN	CYBB	physical	16179592
MYH10_HUMAN	MYH10	physical	22939629
MK03_HUMAN	MAPK3	physical	15655247
MK01_HUMAN	MAPK1	physical	15655247
CDC42_HUMAN	CDC42	physical	15655247
CD44_HUMAN	CD44	physical	15655247
TGFR2_HUMAN	TGFBR2	physical	23454766
MEN1_HUMAN	MEN1	physical	19079338
BRAF_HUMAN	BRAF	physical	18567582
GAPD1_HUMAN	GAPVD1	physical	22863883
RUVB1_HUMAN	RUVBL1	physical	22863883
LGR4_HUMAN	LGR4	physical	24639526
LRP6_HUMAN	LRP6	physical	24639526
DVL2_HUMAN	DVL2	physical	24639526
MP2K1_HUMAN	MAP2K1	physical	24639526
MP2K2_HUMAN	MAP2K2	physical	24639526
FAK1_HUMAN	PTK2	physical	24639526
WASL_HUMAN	WASL	physical	24639526
PAXI_HUMAN	PXN	physical	24639526
DIAP1_HUMAN	DIAPH1	physical	24639526
PDLI7_HUMAN	PDLIM7	physical	25416956
ANXA5_HUMAN	ANXA5	physical	26344197
QCR8_HUMAN	UQCRQ	physical	26344197
UBP7_HUMAN	USP7	physical	26344197
WDR3_HUMAN	WDR3	physical	26344197
ACTB_HUMAN	ACTB	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
ACTN1_HUMAN	ACTN1	physical	26496610
ADDA_HUMAN	ADD1	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2A2_HUMAN	AP2A2	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
DYST_HUMAN	DST	physical	26496610
KCC2G_HUMAN	CAMK2G	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CDC42_HUMAN	CDC42	physical	26496610
CDK4_HUMAN	CDK4	physical	26496610
CDN2A_HUMAN	CDKN2A	physical	26496610
ARF_HUMAN	CDKN2A	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
CLIC1_HUMAN	CLIC1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG1_HUMAN	DSG1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
SRC8_HUMAN	CTTN	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
GELS_HUMAN	GSN	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO5B_HUMAN	MYO5B	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
MYPT2_HUMAN	PPP1R12B	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
RAP1A_HUMAN	RAP1A	physical	26496610
SIPA1_HUMAN	SIPA1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
LRRF1_HUMAN	LRRFIP1	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
ZO2_HUMAN	TJP2	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
ARHGH_HUMAN	ARHGEF17	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
ARPC2_HUMAN	ARPC2	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
GA2L1_HUMAN	GAS2L1	physical	26496610
ASCC3_HUMAN	ASCC3	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
LIMC1_HUMAN	LIMCH1	physical	26496610
SI1L3_HUMAN	SIPA1L3	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
ZDHC5_HUMAN	ZDHHC5	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
SI1L1_HUMAN	SIPA1L1	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ZBT20_HUMAN	ZBTB20	physical	26496610
KS6C1_HUMAN	RPS6KC1	physical	26496610
GOLI4_HUMAN	GOLIM4	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
KCTD3_HUMAN	KCTD3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
GTSE1_HUMAN	GTSE1	physical	26496610
SPN90_HUMAN	NCKIPSD	physical	26496610
OXR1_HUMAN	OXR1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
CING_HUMAN	CGN	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
MYO19_HUMAN	MYO19	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
LZTS2_HUMAN	LZTS2	physical	26496610
NEB2_HUMAN	PPP1R9B	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
MISP_HUMAN	MISP	physical	26496610
MYL6B_HUMAN	MYL6B	physical	26496610
PTGR2_HUMAN	PTGR2	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610
MROH6_HUMAN	MROH6	physical	26496610
HECD1_HUMAN	HECTD1	physical	28073378
TERA_HUMAN	VCP	physical	28970065

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IQGA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330 AND SER-1443, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, AND MASSSPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, AND MASSSPECTROMETRY.	15302935 [Abstract]
"IQGAP1 promotes neurite outgrowth in a phosphorylation-dependentmanner."; Li Z., McNulty D.E., Marler K.J.M., Lim L., Hall C., Annan R.S.,Sacks D.B.; J. Biol. Chem. 280:13871-13878(2005). Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1441 ANDSER-1443, MUTAGENESIS OF SER-1441 AND SER-1443, FUNCTION, AND MASSSPECTROMETRY.	15695813 [Abstract]
"Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing anew type of rho-GTPase regulator."; Grohmanova K., Schlaepfer D., Hess D., Gutierrez P., Beck M.,Kroschewski R.; J. Biol. Chem. 279:48495-48504(2004). Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1443,INTERACTION WITH CDC42 AND RAC1, DOMAIN, SUBCELLULAR LOCATION, ANDMASS SPECTROMETRY.	15355962 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1510, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-654 AND TYR-1510, ANDMASS SPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-172, AND MASSSPECTROMETRY.	15592455 [Abstract]

show

show