dbPTM

KS6C1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KS6C1_HUMAN
UniProt AC	Q96S38
Protein Name	Ribosomal protein S6 kinase delta-1
Gene Name	RPS6KC1
Organism	Homo sapiens (Human).
Sequence Length	1066
Subcellular Localization	Cytoplasm . Membrane . Early endosome .
Protein Description	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. [PubMed: 12077123 Plays a role in the recruitment of PRDX3 to early endosomes]
Protein Sequence	MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MTSYRERSADLARFY CCCHHHHHHHHCCEE	22.75	24719451
15	Phosphorylation	SADLARFYTVTEPQR HHHHCCEEECCCCCC	8.51	22817900
16	Phosphorylation	ADLARFYTVTEPQRH HHHCCEEECCCCCCC	20.45	28348404
18	Phosphorylation	LARFYTVTEPQRHPR HCCEEECCCCCCCCC	33.86	28348404
27	Phosphorylation	PQRHPRGYTVYKVTA CCCCCCCCEEEEEEE	8.36	22817900
30	Phosphorylation	HPRGYTVYKVTARVV CCCCCEEEEEEEEHH	7.61	22817900
93	Phosphorylation	VFGRFDETVIEERRQ ECCCCCHHHHHHHHH	28.73	21406692
109	Phosphorylation	AEDLLQFSANIPALY HHHHHHHHCCHHHHC	13.88	-
118	Phosphorylation	NIPALYNSKQLEDFF CHHHHCCCHHHHHHH	14.28	-
192	Phosphorylation	NQNSPIRTFGLNLSS CCCCCCEEEEEECCC	23.83	21964256
198	Phosphorylation	RTFGLNLSSDSSALG EEEEEECCCCCHHHH	30.90	21964256
199	Phosphorylation	TFGLNLSSDSSALGA EEEEECCCCCHHHHH	44.68	21964256
209	Phosphorylation	SALGAVASDSEQSKT HHHHHHCCCCHHCCC	34.76	28348404
229	Phosphorylation	SRSLFPGSLKPKLGK HHHCCCCCCCCCCCC	33.20	24247654
239	Phosphorylation	PKLGKRDYLEKAGEL CCCCCHHHHHHHHHH	22.31	29396449
248	Ubiquitination	EKAGELIKLALKKEE HHHHHHHHHHHHHCC	40.09	-
253	Ubiquitination	LIKLALKKEEEDDYE HHHHHHHHCCCCCHH	71.81	-
259	Phosphorylation	KKEEEDDYEAASDFY HHCCCCCHHHHHHHH	21.57	28796482
263	Phosphorylation	EDDYEAASDFYRKGV CCCHHHHHHHHHHHH	34.99	28796482
266	Phosphorylation	YEAASDFYRKGVDLL HHHHHHHHHHHHHHH	19.19	28796482
268	Ubiquitination	AASDFYRKGVDLLLE HHHHHHHHHHHHHHH	52.48	-
281	Phosphorylation	LEGVQGESSPTRREA HHCCCCCCCHHHHHH	48.74	23401153
282	Phosphorylation	EGVQGESSPTRREAV HCCCCCCCHHHHHHH	26.45	19664994
284	Phosphorylation	VQGESSPTRREAVKR CCCCCCHHHHHHHHH	44.28	30266825
296	Phosphorylation	VKRRTAEYLMRAESI HHHHHHHHHHHHHHH	11.88	24114839
302	Phosphorylation	EYLMRAESISSLYGK HHHHHHHHHHHHHCC	27.13	29978859
304	Phosphorylation	LMRAESISSLYGKPQ HHHHHHHHHHHCCCC	24.46	29978859
305	Phosphorylation	MRAESISSLYGKPQL HHHHHHHHHHCCCCC	24.76	29978859
307	Phosphorylation	AESISSLYGKPQLDD HHHHHHHHCCCCCCC	25.67	27642862
316	Phosphorylation	KPQLDDVSQPPGSLS CCCCCCCCCCCCCCC	43.92	25850435
321	Phosphorylation	DVSQPPGSLSSRPLW CCCCCCCCCCCCCCC	30.74	25850435
323	Phosphorylation	SQPPGSLSSRPLWNL CCCCCCCCCCCCCCC	26.46	25850435
324	Phosphorylation	QPPGSLSSRPLWNLR CCCCCCCCCCCCCCC	43.12	25850435
332	Phosphorylation	RPLWNLRSPAEELKA CCCCCCCCHHHHHHH	31.46	19664994
378	Phosphorylation	EYSRNRKTIIPRCVP HHHCCCCCCCCCHHC	22.39	-
423	Phosphorylation	ISKFLNRSPEESFDI HHHHHCCCHHHCCCH	35.27	29255136
427	Phosphorylation	LNRSPEESFDIKEVK HCCCHHHCCCHHHCC	26.93	25159151
431	Ubiquitination	PEESFDIKEVKKPTL HHHCCCHHHCCCCCE	59.30	-
437	Phosphorylation	IKEVKKPTLAKVHLQ HHHCCCCCEEEEEEC	48.50	-
447	Phosphorylation	KVHLQQPTSSPQDSS EEEECCCCCCCCCCC	37.18	28450419
448	Phosphorylation	VHLQQPTSSPQDSSS EEECCCCCCCCCCCC	46.86	26657352
449	Phosphorylation	HLQQPTSSPQDSSSF EECCCCCCCCCCCCC	29.11	23927012
453	Phosphorylation	PTSSPQDSSSFESRG CCCCCCCCCCCCCCC	23.72	28450419
454	Phosphorylation	TSSPQDSSSFESRGS CCCCCCCCCCCCCCC	47.54	28450419
455	Phosphorylation	SSPQDSSSFESRGSD CCCCCCCCCCCCCCC	36.66	28450419
458	Phosphorylation	QDSSSFESRGSDGGS CCCCCCCCCCCCCCC	39.67	28450419
461	Phosphorylation	SSFESRGSDGGSMLK CCCCCCCCCCCCCCC	31.78	29255136
465	Phosphorylation	SRGSDGGSMLKALPL CCCCCCCCCCCCEEC	26.86	27732954
477	Phosphorylation	LPLKSSLTPSSQDDS EECCCCCCCCCCCCC	24.07	30576142
480	Phosphorylation	KSSLTPSSQDDSNQE CCCCCCCCCCCCCCC	38.54	30576142
493	Phosphorylation	QEDDGQDSSPKWPDS CCCCCCCCCCCCCCC	40.42	30576142
494	Phosphorylation	EDDGQDSSPKWPDSG CCCCCCCCCCCCCCC	38.50	-
500	Phosphorylation	SSPKWPDSGSSSEEE CCCCCCCCCCCCHHH	36.17	-
528	Phosphorylation	QEKIEPGSLNEEPFM CCCCCCCCCCCCCCC	38.44	30266825
549	Phosphorylation	VDTKAIKSFPAHLAA CCHHHHHHCCCHHHC	30.28	28985074
558	Phosphorylation	PAHLAADSDSPSTQL CCHHHCCCCCHHHHH	34.95	29396449
560	Phosphorylation	HLAADSDSPSTQLRA HHHCCCCCHHHHHCH	25.38	25159151
562	Phosphorylation	AADSDSPSTQLRAHE HCCCCCHHHHHCHHE	32.51	29396449
563	Phosphorylation	ADSDSPSTQLRAHEL CCCCCHHHHHCHHEE	34.70	29396449
571	Ubiquitination	QLRAHELKFFPNDDP HHCHHEECCCCCCCH	41.81	-
582	Phosphorylation	NDDPEAVSSPRTSDS CCCHHHHCCCCCCCC	41.49	25850435
583	Phosphorylation	DDPEAVSSPRTSDSL CCHHHHCCCCCCCCC	16.29	25850435
586	Phosphorylation	EAVSSPRTSDSLSRS HHHCCCCCCCCCCCC	40.03	26074081
587	Phosphorylation	AVSSPRTSDSLSRSK HHCCCCCCCCCCCCC	26.87	26074081
589	Phosphorylation	SSPRTSDSLSRSKNS CCCCCCCCCCCCCCC	28.19	25159151
591	Phosphorylation	PRTSDSLSRSKNSPM CCCCCCCCCCCCCCC	38.16	21964256
593	Phosphorylation	TSDSLSRSKNSPMEF CCCCCCCCCCCCCEE	32.58	29978859
596	Phosphorylation	SLSRSKNSPMEFFRI CCCCCCCCCCEEEEE	29.38	25159151
605	Phosphorylation	MEFFRIDSKDSASEL CEEEEECCCCCHHHH	35.67	30266825
606	Ubiquitination	EFFRIDSKDSASELL EEEEECCCCCHHHHC	52.53	-
608	Phosphorylation	FRIDSKDSASELLGL EEECCCCCHHHHCCC	37.11	30266825
610	Phosphorylation	IDSKDSASELLGLDF ECCCCCHHHHCCCCH	32.50	30266825
620	Ubiquitination	LGLDFGEKLYSLKSE CCCCHHHHHHCCCCC	53.77	-
622	Phosphorylation	LDFGEKLYSLKSEPL CCHHHHHHCCCCCCC	24.03	23312004
623	Phosphorylation	DFGEKLYSLKSEPLK CHHHHHHCCCCCCCC	39.49	24719451
626	Phosphorylation	EKLYSLKSEPLKPFF HHHHCCCCCCCCCCE	50.14	19690332
630	Ubiquitination	SLKSEPLKPFFTLPD CCCCCCCCCCEECCC	50.96	-
634	Phosphorylation	EPLKPFFTLPDGDSA CCCCCCEECCCCCCC	37.45	19690332
640	Phosphorylation	FTLPDGDSASRSFNT EECCCCCCCCCCCCC	33.40	23401153
642	Phosphorylation	LPDGDSASRSFNTSE CCCCCCCCCCCCCCC	32.20	27050516
644	Phosphorylation	DGDSASRSFNTSESK CCCCCCCCCCCCCCC	21.98	26657352
647	Phosphorylation	SASRSFNTSESKVEF CCCCCCCCCCCCEEE	31.68	25627689
648	Phosphorylation	ASRSFNTSESKVEFK CCCCCCCCCCCEEEE	40.76	26055452
651	Ubiquitination	SFNTSESKVEFKAQD CCCCCCCCEEEEEEC	41.55	21906983
659	Phosphorylation	VEFKAQDTISRGSDD EEEEEECCCCCCCCC	14.58	25159151
661	Phosphorylation	FKAQDTISRGSDDSV EEEECCCCCCCCCCC	32.45	30278072
664	Phosphorylation	QDTISRGSDDSVPVI ECCCCCCCCCCCEEE	36.81	30266825
667	Phosphorylation	ISRGSDDSVPVISFK CCCCCCCCCEEEEEC	33.05	30266825
672	Phosphorylation	DDSVPVISFKDAAFD CCCCEEEEECCCEEC	26.86	23403867
674	Ubiquitination	SVPVISFKDAAFDDV CCEEEEECCCEECCC	39.40	21906983
682	Phosphorylation	DAAFDDVSGTDEGRP CCEECCCCCCCCCCC	42.86	27251275
737	Phosphorylation	DVLCLRLSTEQCQAH CEEEEECCHHHHHHH	24.38	29255136
738	Phosphorylation	VLCLRLSTEQCQAHE EEEEECCHHHHHHHH	34.37	29255136
759	Ubiquitination	LSDPSGPKSYSITEK HCCCCCCCCCCCCHH	66.60	21906983
760	Phosphorylation	SDPSGPKSYSITEKH CCCCCCCCCCCCHHH	27.52	29052541
761	Phosphorylation	DPSGPKSYSITEKHY CCCCCCCCCCCHHHH	15.37	27642862
762	Phosphorylation	PSGPKSYSITEKHYA CCCCCCCCCCHHHHC	30.08	29052541
764	Phosphorylation	GPKSYSITEKHYAQE CCCCCCCCHHHHCCC	32.80	29052541
766	Ubiquitination	KSYSITEKHYAQEDP CCCCCCHHHHCCCCC	33.01	-
768	Phosphorylation	YSITEKHYAQEDPRM CCCCHHHHCCCCCCE	22.50	27642862
784	Phosphorylation	FVAAVDHSSSGDMSL EEEEECCCCCCCCCC	23.03	27251275
785	Phosphorylation	VAAVDHSSSGDMSLL EEEECCCCCCCCCCC	34.61	27080861
786	Phosphorylation	AAVDHSSSGDMSLLP EEECCCCCCCCCCCC	41.65	27080861
790	Phosphorylation	HSSSGDMSLLPSSDP CCCCCCCCCCCCCCC	31.34	27080861
794	Phosphorylation	GDMSLLPSSDPKFQG CCCCCCCCCCCCCCC	47.55	27080861
795	Phosphorylation	DMSLLPSSDPKFQGL CCCCCCCCCCCCCCC	56.86	27080861
823	Phosphorylation	ESLFRICSPLSGANE HHHHHHHHCCCCCCC	26.89	25159151
826	Phosphorylation	FRICSPLSGANEYIA HHHHHCCCCCCCCCC	38.96	21815630
834	Phosphorylation	GANEYIASTDTLKTE CCCCCCCCCCCCCCC	19.77	25850435
835	Phosphorylation	ANEYIASTDTLKTEE CCCCCCCCCCCCCCE	24.79	25850435
837	Phosphorylation	EYIASTDTLKTEEVL CCCCCCCCCCCCEEE	30.18	25850435
840	Phosphorylation	ASTDTLKTEEVLLFT CCCCCCCCCEEEEEE	40.25	23898821
847	Phosphorylation	TEEVLLFTDQTDDLA CCEEEEEECCCCHHH	27.45	23898821
850	Phosphorylation	VLLFTDQTDDLAKEE EEEEECCCCHHHHHC	34.00	23898821
855	Ubiquitination	DQTDDLAKEEPTSLF CCCCHHHHHCCCCCC	70.66	-
859	Phosphorylation	DLAKEEPTSLFQRDS HHHHHCCCCCCCCCC	41.14	27251275
860	Phosphorylation	LAKEEPTSLFQRDSE HHHHCCCCCCCCCCC	37.59	27050516
866	Phosphorylation	TSLFQRDSETKGESG CCCCCCCCCCCCCCC	49.72	23403867
868	Phosphorylation	LFQRDSETKGESGLV CCCCCCCCCCCCCEE	48.58	23403867
869	Ubiquitination	FQRDSETKGESGLVL CCCCCCCCCCCCEEE	57.54	21906983
872	Phosphorylation	DSETKGESGLVLEGD CCCCCCCCCEEEECC	46.20	25159151
891	Ubiquitination	QIFEDLDKKLALASR HHHHHHHHHHHHHHH	57.91	-
946	Phosphorylation	DRGHIQLTYFSRWSE CCCCEEEEEEECHHH	13.22	25849741
947	Phosphorylation	RGHIQLTYFSRWSEV CCCEEEEEEECHHHC	14.24	28985074
949	Phosphorylation	HIQLTYFSRWSEVED CEEEEEEECHHHCCC	23.56	27050516

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KS6C1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KS6C1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KS6C1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SPHK1_HUMAN	SPHK1	physical	12077123
DEN6A_HUMAN	DENND6A	physical	25852190

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KS6C1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, ANDMASS SPECTROMETRY.	17081983 [Abstract]