| UniProt ID | DEN6A_HUMAN | |
|---|---|---|
| UniProt AC | Q8IWF6 | |
| Protein Name | Protein DENND6A | |
| Gene Name | DENND6A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 608 | |
| Subcellular Localization | Recycling endosome . Cytoplasm . | |
| Protein Description | Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.. | |
| Protein Sequence | MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Methylation | ----MALRGPAGLGP ----CCCCCCCCCCC | - | ||
| 13 | Phosphorylation | PAGLGPGSRRPLDEA CCCCCCCCCCCHHHH | 22210691 | ||
| 93 | Ubiquitination | SKLTDREKTNICYLS CCCCCCCCCCEEEEE | - | ||
| 127 | Phosphorylation | QSSGRRVSLHCLLDQ CCCCCCEEEEEHHHH | 29255136 | ||
| 199 | Ubiquitination | IAPEYFEKNEPYLEA HCHHHHHCCCCHHHH | 29967540 | ||
| 221 | Ubiquitination | WPAPVPGKTLHLPIM CCCCCCCCEEECEEE | 29967540 | ||
| 308 | Ubiquitination | SPSESSETVLALVNC CCCCCHHHHHHHHHH | 22817900 | ||
| 309 | Ubiquitination | PSESSETVLALVNCI CCCCHHHHHHHHHHH | 22817900 | ||
| 331 | Ubiquitination | DFRPYFTIHDSEFKE CCCCEEEECHHHHHH | 27667366 | ||
| 332 | Ubiquitination | FRPYFTIHDSEFKEY CCCEEEECHHHHHHH | 27667366 | ||
| 354 | Ubiquitination | PSVILGVTNPFFAKT CCEEECCCCHHHHHH | 27667366 | ||
| 355 | Ubiquitination | SVILGVTNPFFAKTL CEEECCCCHHHHHHH | 27667366 | ||
| 360 | Ubiquitination | VTNPFFAKTLQHWPH CCCHHHHHHHHHCCE | 32015554 | ||
| 374 | Ubiquitination | HIIRIGDLKPTGEIP EEEEECCCCCCCCCC | 22817900 | ||
| 375 | Ubiquitination | IIRIGDLKPTGEIPK EEEECCCCCCCCCCC | 21906983 | ||
| 393 | Ubiquitination | VKKLKNLKTLDSKPG EEECCCCCCCCCCCC | 29967540 | ||
| 397 | Ubiquitination | KNLKTLDSKPGVYTS CCCCCCCCCCCCCCC | 27667366 | ||
| 398 | Ubiquitination | NLKTLDSKPGVYTSY CCCCCCCCCCCCCCC | 27667366 | ||
| 406 | Ubiquitination | PGVYTSYKPYLNRDE CCCCCCCCCCCCCCH | 32015554 | ||
| 417 | Ubiquitination | NRDEEIIKQLQKGVQ CCCHHHHHHHHHHHH | 22817900 | ||
| 418 | Ubiquitination | RDEEIIKQLQKGVQQ CCHHHHHHHHHHHHC | 22817900 | ||
| 420 | Ubiquitination | EEIIKQLQKGVQQKR HHHHHHHHHHHHCCC | 27667366 | ||
| 421 | Ubiquitination | EIIKQLQKGVQQKRP HHHHHHHHHHHCCCC | 22817900 | ||
| 422 | Ubiquitination | IIKQLQKGVQQKRPS HHHHHHHHHHCCCCH | 22817900 | ||
| 463 | Ubiquitination | ASLMPLQKSISPWKS HHHCCHHCCCCCCCC | - | ||
| 469 | Ubiquitination | QKSISPWKSPPQLRQ HCCCCCCCCCHHHHH | 29967540 | ||
| 470 | Phosphorylation | KSISPWKSPPQLRQF CCCCCCCCCHHHHHH | 23186163 | ||
| 483 | Ubiquitination | QFLPEEFMKTLEKTG HHCCHHHHHHHHHHC | 22817900 | ||
| 484 | Ubiquitination | FLPEEFMKTLEKTGP HCCHHHHHHHHHHCC | 22817900 | ||
| 487 | Ubiquitination | EEFMKTLEKTGPQLT HHHHHHHHHHCCCHH | 22817900 | ||
| 488 | Ubiquitination | EFMKTLEKTGPQLTS HHHHHHHHHCCCHHH | 22817900 | ||
| 495 | Phosphorylation | KTGPQLTSRIKGDWI HHCCCHHHHCCCCHH | 24719451 | ||
| 498 | Ubiquitination | PQLTSRIKGDWIGLY CCHHHHCCCCHHHHH | - | ||
| 505 | Phosphorylation | KGDWIGLYRHFLKSP CCCHHHHHHHHHHCC | 24719451 | ||
| 510 | Methylation | GLYRHFLKSPNFDGW HHHHHHHHCCCCCCC | 24129315 | ||
| 564 | Ubiquitination | LVLKLKNKLLQADRE HHHHHHHHHHHCCHH | 29967540 | ||
| 605 | Phosphorylation | LQGILLKTGMT---- HHHHHHHCCCC---- | 22210691 | ||
| 608 | Phosphorylation | ILLKTGMT------- HHHHCCCC------- | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DEN6A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DEN6A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DEN6A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DEN6A_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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