LRRF2_HUMAN - dbPTM
LRRF2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRRF2_HUMAN
UniProt AC Q9Y608
Protein Name Leucine-rich repeat flightless-interacting protein 2
Gene Name LRRFIP2
Organism Homo sapiens (Human).
Sequence Length 721
Subcellular Localization
Protein Description May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding..
Protein Sequence MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGTPASGRKR
-----CCCCCCCCCC		17.8725367160
8MethylationMGTPASGRKRTPVKD
CCCCCCCCCCCCCCC		23.84115389599
11PhosphorylationPASGRKRTPVKDRFS
CCCCCCCCCCCCCCC		35.1526074081
18PhosphorylationTPVKDRFSAEDEALS
CCCCCCCCHHHHHHH		31.4830266825
25PhosphorylationSAEDEALSNIAREAE
CHHHHHHHHHHHHHH		32.9823403867
80PhosphorylationQKWLEDSERARYSHR
HHHHHHHHHHHHCCC		63.7833259812
85PhosphorylationDSERARYSHRSSHHR
HHHHHHHCCCCCCCC		13.5826074081
88PhosphorylationRARYSHRSSHHRPYL
HHHHCCCCCCCCCCC		28.7119664995
89PhosphorylationARYSHRSSHHRPYLG
HHHCCCCCCCCCCCC		24.2226074081
96PhosphorylationSHHRPYLGVEDALSI
CCCCCCCCHHHCCCC		18.2232142685
96 (in isoform 2)Phosphorylation-18.2222617229
99 (in isoform 2)Phosphorylation-50.8622199227
100 (in isoform 2)Phosphorylation-6.9522199227
101 (in isoform 2)Phosphorylation-7.2722199227
102PhosphorylationLGVEDALSIRSVGSH
CCHHHCCCCCCCCCC		20.0626437602
107 (in isoform 2)Phosphorylation-20.9818669648
108PhosphorylationLSIRSVGSHRYDMFK
CCCCCCCCCCCHHCC		11.5725690035
108 (in isoform 2)Phosphorylation-11.5725159151
110 (in isoform 2)Phosphorylation-30.7421406692
111PhosphorylationRSVGSHRYDMFKDRS
CCCCCCCCHHCCCCH		13.31-
114PhosphorylationGSHRYDMFKDRSSRL
CCCCCHHCCCCHHHH		7.3233259812
115 (in isoform 2)Phosphorylation-45.6621406692
117 (in isoform 2)Phosphorylation-36.8021406692
118PhosphorylationYDMFKDRSSRLSSLN
CHHCCCCHHHHHHCC		29.9130576142
119UbiquitinationDMFKDRSSRLSSLNH
HHCCCCHHHHHHCCC		37.8324816145
122PhosphorylationKDRSSRLSSLNHSYS
CCCHHHHHHCCCCCH		31.5027134283
123PhosphorylationDRSSRLSSLNHSYSH
CCHHHHHHCCCCCHH		37.4727134283
128PhosphorylationLSSLNHSYSHSHGMK
HHHCCCCCHHCCCCC		11.67-
129PhosphorylationSSLNHSYSHSHGMKK
HHCCCCCHHCCCCCC		22.8730576142
130PhosphorylationSLNHSYSHSHGMKKR
HCCCCCHHCCCCCCC		18.6432142685
134UbiquitinationSYSHSHGMKKRSSDS
CCHHCCCCCCCCCCC		3.7624816145
149UbiquitinationHKDLLSGLYFDQRNY
HHHHHHHHHCCCCCH		3.2829967540
152PhosphorylationLLSGLYFDQRNYSSL
HHHHHHCCCCCHHHH		32.7333259812
153UbiquitinationLSGLYFDQRNYSSLR
HHHHHCCCCCHHHHC		26.1424816145
160PhosphorylationQRNYSSLRHSKPTSA
CCCHHHHCCCCCCCC		33.7032645325
168PhosphorylationHSKPTSAYYTRQSSS
CCCCCCCCEECCCCC		12.7230576142
168 (in isoform 5)Phosphorylation-12.7222617229
169PhosphorylationSKPTSAYYTRQSSSL
CCCCCCCEECCCCCC		8.6530576142
170UbiquitinationKPTSAYYTRQSSSLY
CCCCCCEECCCCCCC		15.0024816145
171 (in isoform 5)Phosphorylation-20.4722199227
172PhosphorylationTSAYYTRQSSSLYSD
CCCCEECCCCCCCCC		39.6133259812
172 (in isoform 5)Phosphorylation-39.6122199227
173PhosphorylationSAYYTRQSSSLYSDP
CCCEECCCCCCCCCC		20.7122673903
173 (in isoform 5)Phosphorylation-20.7122199227
174PhosphorylationAYYTRQSSSLYSDPL
CCEECCCCCCCCCCC		18.9422673903
175PhosphorylationYYTRQSSSLYSDPLA
CEECCCCCCCCCCCC		36.2522673903
177PhosphorylationTRQSSSLYSDPLATY
ECCCCCCCCCCCCCC		16.9924043423
178PhosphorylationRQSSSLYSDPLATYK
CCCCCCCCCCCCCCC		37.7422673903
179 (in isoform 5)Phosphorylation-28.7718669648
180PhosphorylationSSSLYSDPLATYKSD
CCCCCCCCCCCCCCC		20.2532645325
180 (in isoform 5)Phosphorylation-20.2525159151
182 (in isoform 5)Phosphorylation-17.8021406692
183PhosphorylationLYSDPLATYKSDRAS
CCCCCCCCCCCCCCC		38.8822673903
184PhosphorylationYSDPLATYKSDRASP
CCCCCCCCCCCCCCC		11.6824043423
186PhosphorylationDPLATYKSDRASPTA
CCCCCCCCCCCCCCC		23.1626437602
187 (in isoform 5)Phosphorylation-46.1121406692
188PhosphorylationLATYKSDRASPTANS
CCCCCCCCCCCCCCC		44.0232142685
189 (in isoform 5)Phosphorylation-25.5021406692
190PhosphorylationTYKSDRASPTANSGL
CCCCCCCCCCCCCHH		24.5521220426
200PhosphorylationANSGLLRSASLASLY
CCCHHHHHHHHHHHH		23.3721220426
202PhosphorylationSGLLRSASLASLYNG
CHHHHHHHHHHHHCC		26.2221220426
205PhosphorylationLRSASLASLYNGGLY
HHHHHHHHHHCCCCC		36.3621220426
207UbiquitinationSASLASLYNGGLYNP
HHHHHHHHCCCCCCC		14.8524816145
219PhosphorylationYNPYGPRTPSECSYY
CCCCCCCCHHHHHCH		34.01-
225PhosphorylationRTPSECSYYSSRISS
CCHHHHHCHHHCCCC		21.01-
231PhosphorylationSYYSSRISSARSSPG
HCHHHCCCCCCCCCC		19.4820044836
232PhosphorylationYYSSRISSARSSPGF
CHHHCCCCCCCCCCC		25.9020044836
235PhosphorylationSRISSARSSPGFTND
HCCCCCCCCCCCCCC		40.37-
236PhosphorylationRISSARSSPGFTNDD
CCCCCCCCCCCCCCC		24.4020044836
244PhosphorylationPGFTNDDTASIVSSD
CCCCCCCCHHHHCCC		25.7630387612
246PhosphorylationFTNDDTASIVSSDRA
CCCCCCHHHHCCCCH		26.1430387612
249PhosphorylationDDTASIVSSDRASRG
CCCHHHHCCCCHHCC		25.5030576142
250PhosphorylationDTASIVSSDRASRGR
CCHHHHCCCCHHCCC		21.88-
256UbiquitinationSSDRASRGRRESVVS
CCCCHHCCCHHHHHH		30.4224816145
260PhosphorylationASRGRRESVVSAADY
HHCCCHHHHHHHHHH		26.4726437602
263PhosphorylationGRRESVVSAADYFSR
CCHHHHHHHHHHHHC		18.6422673903
264UbiquitinationRRESVVSAADYFSRS
CHHHHHHHHHHHHCC		7.8624816145
266PhosphorylationESVVSAADYFSRSNR
HHHHHHHHHHHCCCC		44.7333259812
267PhosphorylationSVVSAADYFSRSNRR
HHHHHHHHHHCCCCC		9.95-
271UbiquitinationAADYFSRSNRRGSVV
HHHHHHCCCCCCCCE		33.2324816145
274PhosphorylationYFSRSNRRGSVVSEV
HHHCCCCCCCCEEEE		46.0932645325
276PhosphorylationSRSNRRGSVVSEVDD
HCCCCCCCCEEEECC		19.9626699800
279PhosphorylationNRRGSVVSEVDDISI
CCCCCCEEEECCCCC		29.7326699800
279UbiquitinationNRRGSVVSEVDDISI
CCCCCCEEEECCCCC		29.7324816145
280UbiquitinationRRGSVVSEVDDISIP
CCCCCEEEECCCCCC		38.0524816145
282PhosphorylationGSVVSEVDDISIPDL
CCCEEEECCCCCCCH		43.4032142685
285PhosphorylationVSEVDDISIPDLSSL
EEEECCCCCCCHHHC		34.7530576142
290UbiquitinationDISIPDLSSLDEKSD
CCCCCCHHHCCHHHH		35.9124816145
291PhosphorylationISIPDLSSLDEKSDK
CCCCCHHHCCHHHHH		47.3324719451
296PhosphorylationLSSLDEKSDKQYAEN
HHHCCHHHHHHHHHH		48.2528796482
298UbiquitinationSLDEKSDKQYAENYT
HCCHHHHHHHHHHCC		52.9124816145
300PhosphorylationDEKSDKQYAENYTRP
CHHHHHHHHHHCCCC		22.9421945579
300UbiquitinationDEKSDKQYAENYTRP
CHHHHHHHHHHCCCC		22.9424816145
304PhosphorylationDKQYAENYTRPSSRN
HHHHHHHCCCCCCCC		8.8121945579
305PhosphorylationKQYAENYTRPSSRNS
HHHHHHCCCCCCCCC		47.9221945579
308PhosphorylationAENYTRPSSRNSASA
HHHCCCCCCCCCCCC		38.3421945579
309PhosphorylationENYTRPSSRNSASAT
HHCCCCCCCCCCCCC		37.8621945579
311UbiquitinationYTRPSSRNSASATTP
CCCCCCCCCCCCCCC		43.8224816145
312PhosphorylationTRPSSRNSASATTPL
CCCCCCCCCCCCCCC		23.6120044836
314PhosphorylationPSSRNSASATTPLSG
CCCCCCCCCCCCCCC		26.4330266825
314UbiquitinationPSSRNSASATTPLSG
CCCCCCCCCCCCCCC		26.4324816145
315UbiquitinationSSRNSASATTPLSGN
CCCCCCCCCCCCCCC		18.4024816145
316PhosphorylationSRNSASATTPLSGNS
CCCCCCCCCCCCCCC		26.8430266825
317PhosphorylationRNSASATTPLSGNSS
CCCCCCCCCCCCCCC		23.1929255136
320PhosphorylationASATTPLSGNSSRRG
CCCCCCCCCCCCCCC		36.8129255136
320UbiquitinationASATTPLSGNSSRRG
CCCCCCCCCCCCCCC		36.8124816145
321UbiquitinationSATTPLSGNSSRRGS
CCCCCCCCCCCCCCC		45.8024816145
323PhosphorylationTTPLSGNSSRRGSGD
CCCCCCCCCCCCCCC		28.8429255136
324PhosphorylationTPLSGNSSRRGSGDT
CCCCCCCCCCCCCCH		29.9629255136
324UbiquitinationTPLSGNSSRRGSGDT
CCCCCCCCCCCCCCH		29.9624816145
326MethylationLSGNSSRRGSGDTSS
CCCCCCCCCCCCHHH		45.65115482331
328PhosphorylationGNSSRRGSGDTSSLI
CCCCCCCCCCHHHCC		31.5129255136
331PhosphorylationSRRGSGDTSSLIDPD
CCCCCCCHHHCCCCC		24.6022167270
332PhosphorylationRRGSGDTSSLIDPDT
CCCCCCHHHCCCCCC		28.0822167270
333PhosphorylationRGSGDTSSLIDPDTS
CCCCCHHHCCCCCCC		31.2822167270
334UbiquitinationGSGDTSSLIDPDTSL
CCCCHHHCCCCCCCH		5.2924816145
335UbiquitinationSGDTSSLIDPDTSLS
CCCHHHCCCCCCCHH		8.5824816145
336UbiquitinationGDTSSLIDPDTSLSE
CCHHHCCCCCCCHHH		40.0724816145
337UbiquitinationDTSSLIDPDTSLSEL
CHHHCCCCCCCHHHH		39.5224816145
339PhosphorylationSSLIDPDTSLSELRD
HHCCCCCCCHHHHHH		36.6330266825
340PhosphorylationSLIDPDTSLSELRDI
HCCCCCCCHHHHHHH		36.9630266825
342PhosphorylationIDPDTSLSELRDIYD
CCCCCCHHHHHHHHC		34.0630266825
345UbiquitinationDTSLSELRDIYDLKD
CCCHHHHHHHHCHHH		24.9924816145
348PhosphorylationLSELRDIYDLKDQIQ
HHHHHHHHCHHHHHH		21.3623403867
348UbiquitinationLSELRDIYDLKDQIQ
HHHHHHHHCHHHHHH		21.3624816145
350UbiquitinationELRDIYDLKDQIQDV
HHHHHHCHHHHHHHH		3.5524816145
351UbiquitinationLRDIYDLKDQIQDVE
HHHHHCHHHHHHHHH		44.6924816145
355UbiquitinationYDLKDQIQDVEGRYM
HCHHHHHHHHHHHHH		42.9624816145
359UbiquitinationDQIQDVEGRYMQGLK
HHHHHHHHHHHHHHH		26.3524816145
360UbiquitinationQIQDVEGRYMQGLKE
HHHHHHHHHHHHHHH		15.3924816145
365UbiquitinationEGRYMQGLKELKESL
HHHHHHHHHHHHHHH		1.8824816145
370UbiquitinationQGLKELKESLSEVEE
HHHHHHHHHHHHHHH		70.3224816145
379UbiquitinationLSEVEEKYKKAMVSN
HHHHHHHHHHHHHHH		22.4724816145
381UbiquitinationEVEEKYKKAMVSNAQ
HHHHHHHHHHHHHHC		38.3329967540
383SulfoxidationEEKYKKAMVSNAQLD
HHHHHHHHHHHHCCC		4.6930846556
389UbiquitinationAMVSNAQLDNEKNNL
HHHHHHCCCCCCCCC		7.6924816145
396UbiquitinationLDNEKNNLIYQVDTL
CCCCCCCCEEEHHHH		5.5824816145
398PhosphorylationNEKNNLIYQVDTLKD
CCCCCCEEEHHHHHH		12.9725159151
410UbiquitinationLKDVIEEQEEQMAEF
HHHHHHHHHHHHHHH		46.8924816145
413UbiquitinationVIEEQEEQMAEFYRE
HHHHHHHHHHHHHHH		35.3224816145
420UbiquitinationQMAEFYRENEEKSKE
HHHHHHHHCHHHHHH		58.5824816145
423UbiquitinationEFYRENEEKSKELER
HHHHHCHHHHHHHHH		74.3724816145
433UbiquitinationKELERQKHMCSVLQH
HHHHHHHHHHHHHHH		17.7224816145
444UbiquitinationVLQHKMEELKEGLRQ
HHHHHHHHHHHHHHH		62.7424816145
447UbiquitinationHKMEELKEGLRQRDE
HHHHHHHHHHHHHHH		75.8824816145
454UbiquitinationEGLRQRDELIEEKQR
HHHHHHHHHHHHHHH		54.5624816145
458UbiquitinationQRDELIEEKQRMQQK
HHHHHHHHHHHHHHH		47.7124816145
459UbiquitinationRDELIEEKQRMQQKI
HHHHHHHHHHHHHHH		30.3424816145
464UbiquitinationEEKQRMQQKIDTMTK
HHHHHHHHHHHHHHH		35.0224816145
468O-linked_GlycosylationRMQQKIDTMTKEVFD
HHHHHHHHHHHHHHH		30.1630379171
468PhosphorylationRMQQKIDTMTKEVFD
HHHHHHHHHHHHHHH		30.1620068231
470PhosphorylationQQKIDTMTKEVFDLQ
HHHHHHHHHHHHHHH		26.5830206219
476UbiquitinationMTKEVFDLQETLLWK
HHHHHHHHHHHHHHC		3.1724816145
478UbiquitinationKEVFDLQETLLWKDK
HHHHHHHHHHHHCCC		49.0424816145
479PhosphorylationEVFDLQETLLWKDKK
HHHHHHHHHHHCCCC		17.7530206219
488UbiquitinationLWKDKKIGALEKQKE
HHCCCCCCHHHHHHH		32.7524816145
490UbiquitinationKDKKIGALEKQKEYI
CCCCCCHHHHHHHHH		7.7224816145
495UbiquitinationGALEKQKEYIACLRN
CHHHHHHHHHHHHHC		39.4124816145
505UbiquitinationACLRNERDMLREELA
HHHHCHHHHHHHHHH		34.0024816145
512UbiquitinationDMLREELADLQETVK
HHHHHHHHHHHHHHH		20.8124816145
522UbiquitinationQETVKTGEKHGLVII
HHHHHCCCCCCEEEE		47.3024816145
524UbiquitinationTVKTGEKHGLVIIPD
HHHCCCCCCEEEECC		30.4324816145
526UbiquitinationKTGEKHGLVIIPDGT
HCCCCCCEEEECCCC		2.2124816145
532UbiquitinationGLVIIPDGTPNGDVS
CEEEECCCCCCCCCC		37.4024816145
541UbiquitinationPNGDVSHEPVAGAIT
CCCCCCCCCCCCEEE		33.6824816145
546UbiquitinationSHEPVAGAITVVSQE
CCCCCCCEEEEECHH		5.6424816145
547UbiquitinationHEPVAGAITVVSQEA
CCCCCCEEEEECHHH		2.6924816145
551PhosphorylationAGAITVVSQEAAQVL
CCEEEEECHHHHHHH		20.2629496963
553UbiquitinationAITVVSQEAAQVLES
EEEEECHHHHHHHHH		38.1724816145
560UbiquitinationEAAQVLESAGEGPLD
HHHHHHHHCCCCCHH		37.1024816145
561UbiquitinationAAQVLESAGEGPLDV
HHHHHHHCCCCCHHH		15.6424816145
562UbiquitinationAQVLESAGEGPLDVR
HHHHHHCCCCCHHHH		50.0724816145
563UbiquitinationQVLESAGEGPLDVRL
HHHHHCCCCCHHHHH		58.3024816145
575UbiquitinationVRLRKLAGEKEELLS
HHHHHHHCCHHHHHH		57.8724816145
576UbiquitinationRLRKLAGEKEELLSQ
HHHHHHCCHHHHHHH		52.2524816145
5772-HydroxyisobutyrylationLRKLAGEKEELLSQI
HHHHHCCHHHHHHHH		56.42-
577AcetylationLRKLAGEKEELLSQI
HHHHHCCHHHHHHHH		56.4226051181
577UbiquitinationLRKLAGEKEELLSQI
HHHHHCCHHHHHHHH		56.4224816145
587UbiquitinationLLSQIRKLKLQLEEE
HHHHHHHHHHHHHHH		4.8724816145
589UbiquitinationSQIRKLKLQLEEERQ
HHHHHHHHHHHHHHH		11.5724816145
604UbiquitinationKCSRNDGTVGDLAGL
HHHCCCCCHHHHHHC		24.9524816145
611UbiquitinationTVGDLAGLQNGSDLQ
CHHHHHHCCCCCCCC		2.7324816145
615PhosphorylationLAGLQNGSDLQFIEM
HHHCCCCCCCCCEEH		42.5727251275
621UbiquitinationGSDLQFIEMQRDANR
CCCCCCEEHHHHHHH		30.4724816145
623UbiquitinationDLQFIEMQRDANRQI
CCCCEEHHHHHHHHH		27.5824816145
625UbiquitinationQFIEMQRDANRQISE
CCEEHHHHHHHHHHH		31.1624816145
638PhosphorylationSEYKFKLSKAEQDIT
HHHHHHHCHHHHHHH		30.3425247763
640UbiquitinationYKFKLSKAEQDITTL
HHHHHCHHHHHHHHH		19.1224816145
645UbiquitinationSKAEQDITTLEQSIS
CHHHHHHHHHHHHHH		33.3524816145
646UbiquitinationKAEQDITTLEQSISR
HHHHHHHHHHHHHHH		28.7324816145
652PhosphorylationTTLEQSISRLEGQVL
HHHHHHHHHHHHHHH		35.7425247763
652UbiquitinationTTLEQSISRLEGQVL
HHHHHHHHHHHHHHH		35.7424816145
659UbiquitinationSRLEGQVLRYKTAAE
HHHHHHHHHHHHHHH		3.6824816145
660UbiquitinationRLEGQVLRYKTAAEN
HHHHHHHHHHHHHHH		31.8524816145
661UbiquitinationLEGQVLRYKTAAENA
HHHHHHHHHHHHHHH		14.4524816145
662UbiquitinationEGQVLRYKTAAENAE
HHHHHHHHHHHHHHH		25.8324816145
675UbiquitinationAEKVEDELKAEKRKL
HHHHHHHHHHHHHHH		11.1624816145
676UbiquitinationEKVEDELKAEKRKLQ
HHHHHHHHHHHHHHH		53.0724816145
699PhosphorylationKIEEMEMTNSHLAKR
HHHHHHHHHHHHHHH		21.9128270605
701PhosphorylationEEMEMTNSHLAKRLE
HHHHHHHHHHHHHHH		15.6528270605
715PhosphorylationEKMKANRTALLAQQ-
HHHHHHHHHHHHCC-		22.8228555341
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRRF2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
190SPhosphorylation

21220426
202SPhosphorylation

21220426
202SPhosphorylation

21220426
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRRF2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FLII_HUMANFLIIphysical
19265123
ATPF2_HUMANATPAF2physical
25416956
CAZA1_HUMANCAPZA1physical
26344197
FLII_HUMANFLIIphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRRF2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-324 ANDSER-328, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-323 ANDSER-324, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
"Unambiguous characterization of site-specific phosphorylation ofleucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-likereceptor 4 (TLR4)-mediated signaling.";
Gunawardena H.P., Huang Y., Kenjale R., Wang H., Xie L., Chen X.;
J. Biol. Chem. 286:10897-10910(2011).
Cited for: PROTEIN SEQUENCE OF 186-218 AND 326-345, PHOSPHORYLATION AT SER-190AND SER-202, MUTAGENESIS OF SER-190; SER-200 AND SER-202, AND MASSSPECTROMETRY.

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