| UniProt ID | MYO19_HUMAN | |
|---|---|---|
| UniProt AC | Q96H55 | |
| Protein Name | Unconventional myosin-XIX {ECO:0000303|PubMed:19932026} | |
| Gene Name | MYO19 {ECO:0000303|PubMed:19932026, ECO:0000312|HGNC:HGNC:26234} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 970 | |
| Subcellular Localization |
Mitochondrion outer membrane Peripheral membrane protein . Cytoplasm, cytoskeleton . |
|
| Protein Description | Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. [PubMed: 19932026] | |
| Protein Sequence | MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILLERHRLIHVTSSAFTGLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | VNGHNPGSDGQAREY CCCCCCCCCHHHHHH | 39.56 | 24043423 | |
| 19 | Phosphorylation | SDGQAREYLREDLQE CCHHHHHHHHHHHHH | 12.90 | 24043423 | |
| 36 | Ubiquitination | GGEVLLYKLDDLTRV CCCEEEEECCCCCCC | 45.47 | - | |
| 93 | Phosphorylation | SPELMREYHAAPQPQ CHHHHHHHCCCCCCC | 6.08 | 27642862 | |
| 101 | Ubiquitination | HAAPQPQKLKPHVFT CCCCCCCCCCCCEEE | 66.22 | - | |
| 103 | Ubiquitination | APQPQKLKPHVFTVG CCCCCCCCCCEEECC | 39.86 | - | |
| 103 (in isoform 2) | Ubiquitination | - | 39.86 | - | |
| 118 (in isoform 4) | Ubiquitination | - | 42.99 | 21906983 | |
| 118 (in isoform 3) | Ubiquitination | - | 42.99 | 21906983 | |
| 118 (in isoform 1) | Ubiquitination | - | 42.99 | 21906983 | |
| 118 (in isoform 2) | Ubiquitination | - | 42.99 | 21906983 | |
| 118 | Ubiquitination | EQTYRNVKSLIEPVN HHHHHCHHHHHCCCC | 42.99 | 21906983 | |
| 138 (in isoform 4) | Ubiquitination | - | 40.11 | 21906983 | |
| 138 | Ubiquitination | SGESGAGKTWTSRCL ECCCCCCCCHHHHHH | 40.11 | 21906983 | |
| 138 (in isoform 3) | Ubiquitination | - | 40.11 | 21906983 | |
| 138 (in isoform 1) | Ubiquitination | - | 40.11 | 21906983 | |
| 138 (in isoform 2) | Ubiquitination | - | 40.11 | 21906983 | |
| 163 | Ubiquitination | PASWESHKIAERIEQ CCCHHHHHHHHHHHH | 53.54 | 21906983 | |
| 163 (in isoform 1) | Ubiquitination | - | 53.54 | 21906983 | |
| 163 (in isoform 2) | Ubiquitination | - | 53.54 | 21906983 | |
| 163 (in isoform 3) | Ubiquitination | - | 53.54 | 21906983 | |
| 163 (in isoform 4) | Ubiquitination | - | 53.54 | 21906983 | |
| 198 | Ubiquitination | NNSSRFGKFIQLQLN CCCCCCHHHHHHHHH | 36.26 | - | |
| 222 (in isoform 1) | Ubiquitination | - | 41.42 | 21906983 | |
| 222 (in isoform 2) | Ubiquitination | - | 41.42 | 21906983 | |
| 222 (in isoform 3) | Ubiquitination | - | 41.42 | 21906983 | |
| 222 (in isoform 4) | Ubiquitination | - | 41.42 | 21906983 | |
| 222 | Ubiquitination | VQTYLLEKTRVACQA HHHHHHHHHCCCCCC | 41.42 | 21906983 | |
| 243 | Ubiquitination | HIFYQICKGASEDER EEEEEHHCCCCCCCC | 60.17 | - | |
| 328 | Ubiquitination | CQPMDDAKYSVRTAA CCCCCCHHHHHHHHH | 45.08 | - | |
| 336 | Phosphorylation | YSVRTAASLLGLPED HHHHHHHHHCCCCHH | 22.97 | - | |
| 353 | Phosphorylation | LEMVQIRTIRAGRQQ HHHHHHHHHHCCCCC | 19.22 | 20068231 | |
| 497 | Phosphorylation | ECRLNRPSSAAQLQT HHHCCCCCHHHHHHH | 29.40 | 23186163 | |
| 498 | Phosphorylation | CRLNRPSSAAQLQTR HHCCCCCHHHHHHHH | 30.24 | 23312004 | |
| 504 | Phosphorylation | SSAAQLQTRIETALA CHHHHHHHHHHHHHC | 42.05 | 23186163 | |
| 513 | Phosphorylation | IETALAGSPCLGHNK HHHHHCCCCCCCCCC | 13.56 | 28674419 | |
| 520 | Ubiquitination | SPCLGHNKLSREPSF CCCCCCCCCCCCCCE | 42.01 | - | |
| 526 | Phosphorylation | NKLSREPSFIVVHYA CCCCCCCCEEEEEEC | 23.89 | - | |
| 538 | Phosphorylation | HYAGPVRYHTAGLVE EECCCCCHHCCCHHH | 12.08 | 24719451 | |
| 546 | Ubiquitination | HTAGLVEKNKDPIPP HCCCHHHCCCCCCCH | 62.91 | - | |
| 548 | Ubiquitination | AGLVEKNKDPIPPEL CCHHHCCCCCCCHHH | 75.78 | - | |
| 576 | Ubiquitination | GLFPTNPKEKTQEEP CCCCCCCCCCCCCCC | 74.12 | 21906983 | |
| 576 (in isoform 3) | Ubiquitination | - | 74.12 | 21906983 | |
| 576 (in isoform 1) | Ubiquitination | - | 74.12 | 21906983 | |
| 578 | Ubiquitination | FPTNPKEKTQEEPPG CCCCCCCCCCCCCCC | 62.73 | - | |
| 593 | Phosphorylation | QSRAPVLTVVSKFKA CCCCCCHHHHHHHHH | 21.06 | 23909892 | |
| 596 | Phosphorylation | APVLTVVSKFKASLE CCCHHHHHHHHHHHH | 28.21 | 23909892 | |
| 597 (in isoform 3) | Ubiquitination | - | 39.00 | 21906983 | |
| 597 | Ubiquitination | PVLTVVSKFKASLEQ CCHHHHHHHHHHHHH | 39.00 | 2190698 | |
| 597 (in isoform 1) | Ubiquitination | - | 39.00 | 21906983 | |
| 648 | Phosphorylation | EACGLVETIHISAAG HHCCCEEEEEEECCC | 15.46 | - | |
| 679 | Phosphorylation | LRRLHPCTSSGPDSP HHHHCCCCCCCCCCC | 30.31 | 24732914 | |
| 680 | Phosphorylation | RRLHPCTSSGPDSPY HHHCCCCCCCCCCCC | 39.76 | 24732914 | |
| 681 | Phosphorylation | RLHPCTSSGPDSPYP HHCCCCCCCCCCCCC | 35.87 | 24732914 | |
| 685 | Phosphorylation | CTSSGPDSPYPAKGL CCCCCCCCCCCCCCC | 29.48 | 25159151 | |
| 687 | Phosphorylation | SSGPDSPYPAKGLPE CCCCCCCCCCCCCCC | 21.55 | 24732914 | |
| 742 | Ubiquitination | PMHCGRTKVFMTDSM CCCCCCEEEEECHHH | 31.92 | - | |
| 746 | Phosphorylation | GRTKVFMTDSMLELL CCEEEEECHHHHHHH | 17.29 | 28509920 | |
| 748 | Phosphorylation | TKVFMTDSMLELLEC EEEEECHHHHHHHHH | 18.99 | 28509920 | |
| 830 | Ubiquitination | RMACLAAKELDGVEE HHHHHHHHHCCCCCC | 53.88 | - | |
| 838 | Ubiquitination | ELDGVEEKHFSQAPC HCCCCCCCHHCCCCC | 36.12 | - | |
| 846 | Phosphorylation | HFSQAPCSLSTSPLQ HHCCCCCCCCCCHHH | 25.05 | 28555341 | |
| 850 | Phosphorylation | APCSLSTSPLQTRLL CCCCCCCCHHHHHHH | 21.90 | 28555341 | |
| 873 | Phosphorylation | LGLVLANTAMGVGSF HHHHHHHCCCCCCHH | 16.65 | 20068231 | |
| 879 | Phosphorylation | NTAMGVGSFQRKLVV HCCCCCCHHHHHHHH | 18.79 | 20068231 | |
| 901 | Phosphorylation | RGSPSSYTVQTAQDQ CCCCCCCEEEECHHH | 14.21 | 28555341 | |
| 941 | Phosphorylation | ADICPEPSPYSITGF CCCCCCCCCCCCCCH | 34.50 | - | |
| 962 | Phosphorylation | RHRLIHVTSSAFTGL HHCEEEEECHHHCCC | 11.64 | 30108239 | |
| 963 | Phosphorylation | HRLIHVTSSAFTGLG HCEEEEECHHHCCCC | 20.69 | 23898821 | |
| 964 | Phosphorylation | RLIHVTSSAFTGLG- CEEEEECHHHCCCC- | 20.31 | 30631047 | |
| 967 | Phosphorylation | HVTSSAFTGLG---- EEECHHHCCCC---- | 31.08 | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYO19_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYO19_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYO19_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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