K2C72_HUMAN - dbPTM
K2C72_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K2C72_HUMAN
UniProt AC Q14CN4
Protein Name Keratin, type II cytoskeletal 72
Gene Name KRT72
Organism Homo sapiens (Human).
Sequence Length 511
Subcellular Localization
Protein Description Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)..
Protein Sequence MSRQLTHFPRGERLGFSGCSAVLSGGIGSSSASFRARVKGSASFGSKSLSCLGGSRSLALSAAARRGGGRLGGFVGTAFGSAGLGPKCPSVCPPGGIPQVTVNKSLLAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWNLLQQLDLNNCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYKKRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISELNRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVISSTNAGAGGAGFSMGFGASSSYSYKTAAADVKTKGSCGSELKDPLAKTSGSSCATKKASR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSRQLTHFP
------CCCCCCCCC		28.8324719451
6Phosphorylation--MSRQLTHFPRGER
--CCCCCCCCCCCCC		17.0923403867
33PhosphorylationGIGSSSASFRARVKG
CCCCCCHHHHHHHCC		19.7424719451
47AcetylationGSASFGSKSLSCLGG
CCCCCCCCCCEECCC		56.6511618905
50UbiquitinationSFGSKSLSCLGGSRS
CCCCCCCEECCCCHH		17.8721963094
73UbiquitinationRGGGRLGGFVGTAFG
CCCCCCCCHHCHHHC		20.7521963094
135UbiquitinationQIKALNNKFASFIDK
HHHHHHHHHHHHHHH		41.03-
138PhosphorylationALNNKFASFIDKVRF
HHHHHHHHHHHHHHH		26.3528355574
141UbiquitinationNKFASFIDKVRFLEQ
HHHHHHHHHHHHHHH		41.1923503661
142 (in isoform 2)Ubiquitination-30.4121906983
142 (in isoform 1)Ubiquitination-30.4121906983
142AcetylationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.4122640173
142UbiquitinationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.4121963094
161UbiquitinationETKWNLLQQLDLNNC
HHHHHHHHHHCCCHH		44.9823503661
162UbiquitinationTKWNLLQQLDLNNCR
HHHHHHHHHCCCHHH		36.5923503661
164UbiquitinationWNLLQQLDLNNCRKN
HHHHHHHCCCHHHHH		42.9123503661
165UbiquitinationNLLQQLDLNNCRKNL
HHHHHHCCCHHHHHC		7.2523503661
167UbiquitinationLQQLDLNNCRKNLEP
HHHHCCCHHHHHCHH		33.9823503661
168UbiquitinationQQLDLNNCRKNLEPI
HHHCCCHHHHHCHHH		6.7923503661
191PhosphorylationQKQLEMLSGDGVRLD
HHHHHHHHCCCCHHC		33.2622985185
199PhosphorylationGDGVRLDSELRNMQD
CCCCHHCHHHHCHHH		43.0228355574
211PhosphorylationMQDLVEDYKKRYEVE
HHHHHHHHHHHHHHE		12.61-
233UbiquitinationENEFVVLKKDVDAAY
CCEEEEEECCCCHHH		35.0023503661
234UbiquitinationNEFVVLKKDVDAAYM
CEEEEEECCCCHHHH		59.8423503661
240PhosphorylationKKDVDAAYMNKVELQ
ECCCCHHHHCHHHHH		11.7121253578
294PhosphorylationNRDLDLDSIIAEVRA
CCCCCHHHHHHHHHH		24.16-
328PhosphorylationKIQELQVTAGQHGDD
HHEEEEECCCCCCCC		16.4726126808
369PhosphorylationKQCADLETAIADAEQ
HHHCCHHHHHHHHHH		30.5720068231
426PhosphorylationALDMEIATYRKLLES
HHHHHHHHHHHHHHC		29.53-
433PhosphorylationTYRKLLESEECRMSG
HHHHHHHCHHHHHCC		38.3728258704
464PhosphorylationGAGGAGFSMGFGASS
CCCCCCCCCCCCCCC		19.6528857561
473PhosphorylationGFGASSSYSYKTAAA
CCCCCCCCCCCCCCC		20.2628857561
475PhosphorylationGASSSYSYKTAAADV
CCCCCCCCCCCCCCC		12.2528857561
499PhosphorylationLKDPLAKTSGSSCAT
CCCHHHHCCCCCCCC		32.48-
500PhosphorylationKDPLAKTSGSSCATK
CCHHHHCCCCCCCCH		35.65-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K2C72_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K2C72_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K2C72_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K2C72_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K2C72_HUMAN

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Related Literatures of Post-Translational Modification

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